USMLE Step 2 CK High-Yield (New 2026/
2027 Update) Questions & Answers {Grade
A} 100% Correct (Verified Solutions)
Exophytic nodules on the skin with varying degrees of scaling or ulceration; the second
most common type of skin cancer - correct answer Squamous cell carcinoma
The most common cause of hypothyroidism - correct answer Hashimoto's thyroiditis
Lab findings in Hashimotos' thyroiditis - correct answer High TSH, low T4, anti-TPO
antibodies
Exophthalmos, pretibial myxedema, and decreased TSH - correct answer Graves'
disease
The most common cause of Cushing's syndrome - correct answer Iatrogenic
corticosteroid administration. The second most common cause is Cushing's disease
,A patient presents with signs of hypocalcemia, high phosphorus, and low PTH - correct
answer Hypoparathyroidism
Stones, bones, groans, psychic overtones - correct answer Signs and symptoms of
hypercalcemia
A patient complains of HA, weakness and polyuria; exam reveals HTN and tetany. Labs
show hypernatremia, hypokalemia and metabolic alk - correct answer Primary
hyperaldosteronism (due to Conn's syndrome or bilateral adrenal hyperplasia)
A patient p/w tachycardia, wild swings in BP, HA, diaphoresis, AMS and sense of panic
- correct answer Pheo
Which should be used first in treating pheo, alpha or beta-antagonists? - correct
answer Alpha (phentolamine and phenoxybenzamine)
A patient with h/o lithium use p/w copious amounts of dilute urine - correct answer
Nephrogenic DI
,Treatment of central DI - correct answer Administration of DDAVP and free-water
restriction
A postop patient with significant pain p/w hyponatremia and normal volume status -
correct answer SIADH due to stress
An antidiabetic agent a/w lactic acidosis - correct answer Metformin
A patient p/w weakness, n/v, weight loss and new skin pigmentation. Labs show
hyponatremia and hyperkalemia. Treatment? - correct answer Primary adrenal
insufficiency (Addison's). Treat with glucocorticoids, mineralocorticoids and IVF
Goal HbA1c for patient with DM - correct answer <7.0
Treatment of DKA - correct answer Fluids, insulin, and electrolute repletion (eg K+)
, Why are beta-blockers contraindicated in diabetics? - correct answer Can mask
symptoms of hypoglycemia
Bias introduced into a study when a clinician is aware of the patient's treatment type -
correct answer Observational bias
Bias introduced when screening detects a disease earlier and thus lengthens the time
from diagnosis to death - correct answer Lead-time bias
If you want to know if geographical location affects infant mortality rate but most
variation in infant mortality is predicted by socioeconomic status, then socioeconomic
status is a ______ - correct answer Confounding variable
The proportion of people who have the disease and test + is the - correct answer
Sensitivity
Sensitive tests have few false negatives and are used to rule ___ a disease - correct
answer Out
2027 Update) Questions & Answers {Grade
A} 100% Correct (Verified Solutions)
Exophytic nodules on the skin with varying degrees of scaling or ulceration; the second
most common type of skin cancer - correct answer Squamous cell carcinoma
The most common cause of hypothyroidism - correct answer Hashimoto's thyroiditis
Lab findings in Hashimotos' thyroiditis - correct answer High TSH, low T4, anti-TPO
antibodies
Exophthalmos, pretibial myxedema, and decreased TSH - correct answer Graves'
disease
The most common cause of Cushing's syndrome - correct answer Iatrogenic
corticosteroid administration. The second most common cause is Cushing's disease
,A patient presents with signs of hypocalcemia, high phosphorus, and low PTH - correct
answer Hypoparathyroidism
Stones, bones, groans, psychic overtones - correct answer Signs and symptoms of
hypercalcemia
A patient complains of HA, weakness and polyuria; exam reveals HTN and tetany. Labs
show hypernatremia, hypokalemia and metabolic alk - correct answer Primary
hyperaldosteronism (due to Conn's syndrome or bilateral adrenal hyperplasia)
A patient p/w tachycardia, wild swings in BP, HA, diaphoresis, AMS and sense of panic
- correct answer Pheo
Which should be used first in treating pheo, alpha or beta-antagonists? - correct
answer Alpha (phentolamine and phenoxybenzamine)
A patient with h/o lithium use p/w copious amounts of dilute urine - correct answer
Nephrogenic DI
,Treatment of central DI - correct answer Administration of DDAVP and free-water
restriction
A postop patient with significant pain p/w hyponatremia and normal volume status -
correct answer SIADH due to stress
An antidiabetic agent a/w lactic acidosis - correct answer Metformin
A patient p/w weakness, n/v, weight loss and new skin pigmentation. Labs show
hyponatremia and hyperkalemia. Treatment? - correct answer Primary adrenal
insufficiency (Addison's). Treat with glucocorticoids, mineralocorticoids and IVF
Goal HbA1c for patient with DM - correct answer <7.0
Treatment of DKA - correct answer Fluids, insulin, and electrolute repletion (eg K+)
, Why are beta-blockers contraindicated in diabetics? - correct answer Can mask
symptoms of hypoglycemia
Bias introduced into a study when a clinician is aware of the patient's treatment type -
correct answer Observational bias
Bias introduced when screening detects a disease earlier and thus lengthens the time
from diagnosis to death - correct answer Lead-time bias
If you want to know if geographical location affects infant mortality rate but most
variation in infant mortality is predicted by socioeconomic status, then socioeconomic
status is a ______ - correct answer Confounding variable
The proportion of people who have the disease and test + is the - correct answer
Sensitivity
Sensitive tests have few false negatives and are used to rule ___ a disease - correct
answer Out
