ATI CMS PHARMACOLOGY
100+ Questions Full Practice Exam
Assessment Technologies Institute (ATI)
2026/2027 Academic Year
Exam Format: 100 Verified Practice Questions | Timed | Rationales
Content Areas: All High-Yield Drug Classes for CMS
Includes: Colored Answers + Rationales + TOC + Borders + Page Numbers
ATI Pharmacology CMS 2026/2027 - 100Q Full Edition Page 1 Verified Practice Edition
, TABLE OF CONTENTS
I. Cardiovascular Drugs - Q1-20 Page 3-12
II. Anticoagulants & Antiplatelets - Q21-35 Page 13-19
III. Antibiotics & Anti-infectives - Q36-50 Page 20-27
IV. Endocrine - Diabetes, Steroids - Q51-70 Page 28-37
V. Respiratory & GI Drugs - Q71-85 Page 38-45
VI. Pain, Psych, Neuro Drugs - Q86-100 Page 46-53
VII. Answer Key Summary (100Q) Page 54
ATI Pharmacology CMS 2026/2027 - 100Q Full Edition Page 2 Verified Practice Edition
, Question 1: [Digoxin] A nurse is caring for a client receiving Digoxin. Which
finding/nursing action is priority? (Question 1 - Cardiac Glycoside - Digoxin toxicity and
hypokalemia)
A. Hold if HR <60 bpm and check level
B. Give with antacids
C. Potassium 5.8 is okay
D. No need to monitor ECG
CORRECT ANSWER: A. Hold if HR <60 bpm and check level
RATIONALE:
Digoxin: hold if HR<60, check K+ (low K+ increases toxicity), Mg2+, level 0.5-2.0. S/S toxicity: halos,
nausea, bradycardia, dysrhythmias. Antidote Digibind.
Question 2: [Warfarin] A nurse is caring for a client receiving Warfarin. Which
finding/nursing action is priority? (Question 2 - Anticoagulant - Warfarin and INR)
A. INR 2.5 therapeutic
B. Eat large amounts of spinach daily
C. No bleeding precautions needed
D. Stop abruptly
CORRECT ANSWER: A. INR 2.5 therapeutic
RATIONALE:
Warfarin therapeutic INR 2-3 (3-4.5 for mechanical valves). Antidote Vitamin K. Teach consistent
Vitamin K intake, soft toothbrush, electric razor, report bleeding.
Question 3: [Heparin] A nurse is caring for a client receiving Heparin. Which
finding/nursing action is priority? (Question 3 - Anticoagulant - Heparin and aPTT)
A. aPTT 60 sec therapeutic, monitor for bleeding
B. No lab needed
C. Give Vitamin K if bleeding
D. IM injection preferred
CORRECT ANSWER: A. aPTT 60 sec therapeutic, monitor for bleeding
RATIONALE:
Heparin therapeutic aPTT 1.5-2.5x control. Antidote protamine. Risk HIT - check platelets. No IM due
to hematoma.
ATI Pharmacology CMS 2026/2027 - 100Q Full Edition Page 3 Verified Practice Edition
, Question 4: [Clopidogrel] A nurse is caring for a client receiving Clopidogrel. Which
finding/nursing action is priority? (Question 4 - Antiplatelet - Clopidogrel bleeding)
A. Correct action per pharmacology guidelines
B. Incorrect - increases risk
C. Incorrect - not therapeutic
D. Incorrect - unsafe
CORRECT ANSWER: A. Correct action per pharmacology guidelines
RATIONALE:
Clopidogrel: Monitor therapeutic effects, side effects, labs (K+, renal, liver, INR/aPTT, VS). Teach
adherence, interactions, bleeding or toxicity signs, antidote if available. Antiplatelet - Clopidogrel
bleeding is high-yield for ATI.
Question 5: [Morphine] A nurse is caring for a client receiving Morphine. Which
finding/nursing action is priority? (Question 5 - Opioid - Morphine respiratory depression)
A. RR 8/min - hold and give naloxone
B. Constipation is emergency
C. No need to monitor RR
D. Give with grapefruit
CORRECT ANSWER: A. RR 8/min - hold and give naloxone
RATIONALE:
Opioids: respiratory depression (RR<10), sedation, constipation, orthostatic hypotension, miosis.
Antidote naloxone. Encourage fluids, fiber, stool softeners.
Question 6: [Naloxone] A nurse is caring for a client receiving Naloxone. Which
finding/nursing action is priority? (Question 6 - Opioid antagonist - Naloxone)
A. Correct action per pharmacology guidelines
B. Incorrect - increases risk
C. Incorrect - not therapeutic
D. Incorrect - unsafe
CORRECT ANSWER: A. Correct action per pharmacology guidelines
RATIONALE:
Naloxone: Monitor therapeutic effects, side effects, labs (K+, renal, liver, INR/aPTT, VS). Teach
adherence, interactions, bleeding or toxicity signs, antidote if available. Opioid antagonist - Naloxone is
high-yield for ATI.
ATI Pharmacology CMS 2026/2027 - 100Q Full Edition Page 4 Verified Practice Edition
100+ Questions Full Practice Exam
Assessment Technologies Institute (ATI)
2026/2027 Academic Year
Exam Format: 100 Verified Practice Questions | Timed | Rationales
Content Areas: All High-Yield Drug Classes for CMS
Includes: Colored Answers + Rationales + TOC + Borders + Page Numbers
ATI Pharmacology CMS 2026/2027 - 100Q Full Edition Page 1 Verified Practice Edition
, TABLE OF CONTENTS
I. Cardiovascular Drugs - Q1-20 Page 3-12
II. Anticoagulants & Antiplatelets - Q21-35 Page 13-19
III. Antibiotics & Anti-infectives - Q36-50 Page 20-27
IV. Endocrine - Diabetes, Steroids - Q51-70 Page 28-37
V. Respiratory & GI Drugs - Q71-85 Page 38-45
VI. Pain, Psych, Neuro Drugs - Q86-100 Page 46-53
VII. Answer Key Summary (100Q) Page 54
ATI Pharmacology CMS 2026/2027 - 100Q Full Edition Page 2 Verified Practice Edition
, Question 1: [Digoxin] A nurse is caring for a client receiving Digoxin. Which
finding/nursing action is priority? (Question 1 - Cardiac Glycoside - Digoxin toxicity and
hypokalemia)
A. Hold if HR <60 bpm and check level
B. Give with antacids
C. Potassium 5.8 is okay
D. No need to monitor ECG
CORRECT ANSWER: A. Hold if HR <60 bpm and check level
RATIONALE:
Digoxin: hold if HR<60, check K+ (low K+ increases toxicity), Mg2+, level 0.5-2.0. S/S toxicity: halos,
nausea, bradycardia, dysrhythmias. Antidote Digibind.
Question 2: [Warfarin] A nurse is caring for a client receiving Warfarin. Which
finding/nursing action is priority? (Question 2 - Anticoagulant - Warfarin and INR)
A. INR 2.5 therapeutic
B. Eat large amounts of spinach daily
C. No bleeding precautions needed
D. Stop abruptly
CORRECT ANSWER: A. INR 2.5 therapeutic
RATIONALE:
Warfarin therapeutic INR 2-3 (3-4.5 for mechanical valves). Antidote Vitamin K. Teach consistent
Vitamin K intake, soft toothbrush, electric razor, report bleeding.
Question 3: [Heparin] A nurse is caring for a client receiving Heparin. Which
finding/nursing action is priority? (Question 3 - Anticoagulant - Heparin and aPTT)
A. aPTT 60 sec therapeutic, monitor for bleeding
B. No lab needed
C. Give Vitamin K if bleeding
D. IM injection preferred
CORRECT ANSWER: A. aPTT 60 sec therapeutic, monitor for bleeding
RATIONALE:
Heparin therapeutic aPTT 1.5-2.5x control. Antidote protamine. Risk HIT - check platelets. No IM due
to hematoma.
ATI Pharmacology CMS 2026/2027 - 100Q Full Edition Page 3 Verified Practice Edition
, Question 4: [Clopidogrel] A nurse is caring for a client receiving Clopidogrel. Which
finding/nursing action is priority? (Question 4 - Antiplatelet - Clopidogrel bleeding)
A. Correct action per pharmacology guidelines
B. Incorrect - increases risk
C. Incorrect - not therapeutic
D. Incorrect - unsafe
CORRECT ANSWER: A. Correct action per pharmacology guidelines
RATIONALE:
Clopidogrel: Monitor therapeutic effects, side effects, labs (K+, renal, liver, INR/aPTT, VS). Teach
adherence, interactions, bleeding or toxicity signs, antidote if available. Antiplatelet - Clopidogrel
bleeding is high-yield for ATI.
Question 5: [Morphine] A nurse is caring for a client receiving Morphine. Which
finding/nursing action is priority? (Question 5 - Opioid - Morphine respiratory depression)
A. RR 8/min - hold and give naloxone
B. Constipation is emergency
C. No need to monitor RR
D. Give with grapefruit
CORRECT ANSWER: A. RR 8/min - hold and give naloxone
RATIONALE:
Opioids: respiratory depression (RR<10), sedation, constipation, orthostatic hypotension, miosis.
Antidote naloxone. Encourage fluids, fiber, stool softeners.
Question 6: [Naloxone] A nurse is caring for a client receiving Naloxone. Which
finding/nursing action is priority? (Question 6 - Opioid antagonist - Naloxone)
A. Correct action per pharmacology guidelines
B. Incorrect - increases risk
C. Incorrect - not therapeutic
D. Incorrect - unsafe
CORRECT ANSWER: A. Correct action per pharmacology guidelines
RATIONALE:
Naloxone: Monitor therapeutic effects, side effects, labs (K+, renal, liver, INR/aPTT, VS). Teach
adherence, interactions, bleeding or toxicity signs, antidote if available. Opioid antagonist - Naloxone is
high-yield for ATI.
ATI Pharmacology CMS 2026/2027 - 100Q Full Edition Page 4 Verified Practice Edition
