AANP CERTIFICATION ACTUAL VERIFIED EXAM - American Association
of Nurse Practitioners Certification Board - 2026/2027 Academic Year -
Verified Questions and Answers - 105Q REAL
Primary Care Respiratory
Description: Sore throat Centor McIsaac fever exudate tender anterior cervical LAD absence cough age scoring GAS rapid strep AOM
amoxicillin 500 TID 875 BID first line doxy macrolide if allergy CAP outpatient healthy amoxicillin 1 g TID doxy azithro if resistance less than 25
percent comorbidities amox-clav ceph plus macrolide doxy resp FQ asthma ICS low dose first line persistent never LABA alone add LABA
COPD GOLD SABA SAMA albuterol ipratropium steroids prednisone 40 mg 5 days antibiotics if purulent SpO2 88-92.
Cardiac Hypertension
Description: HTN JNC8 less than 140 over 90 general less than 150 over 90 greater than 60 without diabetes CKD ACC AHA less than 130 over
80 high risk HF reduced EF GDMT ACE inhibitor or ARNI beta blocker carvedilol metoprolol bisoprolol MRA spironolactone SGLT2i
dapagliflozin empagliflozin diuretic volume AFib CHA2DS2-VASc score 0 male 1 female no anticoag 1 male 2 female consider 2 male 3 female
anticoag DOAC apixaban rivaroxaban warfarin INR 2-3.
Endocrine Diabetes Thyroid
Description: T2DM first line metformin plus lifestyle if ASCVD HF CKD add SGLT2i or GLP-1 RA regardless A1c eGFR GLP-1 RA
contraindicated medullary thyroid carcinoma MEN2 SGLT2i mechanism proximal tubule glucosuria CV renal benefit hypothyroidism
levothyroxine 1.6 mcg per kg empty stomach 30-60 min before breakfast 4 hr calcium iron hyperthyroidism methimazole first line PTU first
trimester beta blocker propranolol iodine 1 hr after antithyroid agranulocytosis fever sore throat.
GU Renal UTI Contraception
Description: UTI uncomplicated cystitis nitrofurantoin 100 BID 5 days TMP-SMX 3 days if resistance less than 20 percent fosfomycin single dose
avoid FQ first line pyelo cipro 7 days if resistance less than 10 percent TMP-SMX 14 days ceftriaxone 1 dose then oral nitrofurantoin fosfomycin
NOT for pyelo contraception combined OCP contraindicated smoker greater than 35 HTN migraine with aura VTE breast cancer WHO Category
4.
Psych Mental Health Wellness
Description: Depression PHQ-9 SSRI sertraline escitalopram first line plus CBT psychotherapy black box suicide young anxiety GAD SSRI
SNRI plus CBT benzo short term only dependence smoking cessation 5As Ask Advise Assess Assist Arrange NRT varenicline bupropion
behavioral counseling.
Health Promotion Screening
Description: Osteoporosis DEXA women greater than 65 men greater than 70 T score less than -2.5 bisphosphonate alendronate calcium
vitamin D weight bearing prostate PSA shared decision 55-69 USPSTF MMR 12-15 months second dose 4-6 years live attenuated melanoma
ABCDE Asymmetry Border irregular Color variegated Diameter greater than 6 mm Evolving microcytic anemia MCV less than 80 iron deficiency
thalassemia lead chronic disease ferritin TIBC.
Page 1 - AANP 105Q 2026/2027
,Question 1: Q1: Centor sore throat?
A. Fever exudate tender anterior cervical LAD absence cough age scoring
B. Only fever
C. Only cough
D. No criteria
CORRECT ANSWER: A. Fever exudate tender anterior cervical LAD absence cough age scoring
RATIONALE:
Centor McIsaac fever exudate tender anterior cervical LAD absence cough age scoring guides GAS testing.
Question 2: Q2: AOM adult first line?
A. No antibiotics always
B. Only cipro
C. Amoxicillin 500 TID 875 BID first line doxy macrolide if penicillin allergy
D. Only IV vanco
CORRECT ANSWER: C. Amoxicillin 500 TID 875 BID first line doxy macrolide if penicillin allergy
RATIONALE:
AOM first line amoxicillin 500 TID 875 BID 5-7 days penicillin allergy doxy azithro pain control.
Question 3: Q3: CAP outpatient healthy?
A. Meropenem outpatient
B. Vanco outpatient
C. Gentamicin
D. Amoxicillin 1 g TID or doxy or azithro if resistance less than 25 percent
CORRECT ANSWER: D. Amoxicillin 1 g TID or doxy or azithro if resistance less than 25 percent
RATIONALE:
CAP outpatient no comorbidities amoxicillin 1 g TID or doxy or azithro if resistance less than 25 percent.
Question 4: Q4: Asthma controller?
A. LABA alone
B. ICS low dose first line persistent add LABA if not controlled never LABA alone
C. SABA alone persistent
D. No controller
CORRECT ANSWER: B. ICS low dose first line persistent add LABA if not controlled never LABA alone
RATIONALE:
Asthma stepwise low dose ICS first line persistent add LABA if not controlled never LABA alone.
Question 5: Q5: COPD exacerbation?
A. SABA SAMA albuterol ipratropium steroids 40 mg prednisone 5 days antibiotics if purulent
B. Only high flow O2 100 percent
C. Only antibiotics
D. No treatment
CORRECT ANSWER: A. SABA SAMA albuterol ipratropium steroids 40 mg prednisone 5 days antibiotics if purulent
RATIONALE:
COPD exacerbation SABA SAMA bronchodilators steroids prednisone 40 mg 5 days antibiotics if purulent SpO2 88-92.
Question 6: Q6: HTN target?
A. No target
B. Less than 180 over 110
C. Less than 140 over 90 general less than 150 over 90 greater than 60 without DM CKD ACC AHA less than 130 over 80
D. Less than 100 over 60
CORRECT ANSWER: C. Less than 140 over 90 general less than 150 over 90 greater than 60 without DM CKD ACC AHA less
than 130 over 80
RATIONALE:
JNC8 general less than 140/90 less than 150/90 if greater than 60 without DM CKD ACC AHA less than 130/80.
Question 7: Q7: HFrEF GDMT?
A. Only diuretic alone
B. Only digoxin
C. No treatment
D. ACE or ARNI beta blocker carvedilol metoprolol bisoprolol MRA SGLT2i
CORRECT ANSWER: D. ACE or ARNI beta blocker carvedilol metoprolol bisoprolol MRA SGLT2i
RATIONALE:
HFrEF GDMT ACE or ARNI beta blocker carvedilol metoprolol bisoprolol MRA SGLT2i dapa empagliflozin diuretic volume.
Page 2 - AANP 105Q 2026/2027
, Page 3 - AANP 105Q 2026/2027
of Nurse Practitioners Certification Board - 2026/2027 Academic Year -
Verified Questions and Answers - 105Q REAL
Primary Care Respiratory
Description: Sore throat Centor McIsaac fever exudate tender anterior cervical LAD absence cough age scoring GAS rapid strep AOM
amoxicillin 500 TID 875 BID first line doxy macrolide if allergy CAP outpatient healthy amoxicillin 1 g TID doxy azithro if resistance less than 25
percent comorbidities amox-clav ceph plus macrolide doxy resp FQ asthma ICS low dose first line persistent never LABA alone add LABA
COPD GOLD SABA SAMA albuterol ipratropium steroids prednisone 40 mg 5 days antibiotics if purulent SpO2 88-92.
Cardiac Hypertension
Description: HTN JNC8 less than 140 over 90 general less than 150 over 90 greater than 60 without diabetes CKD ACC AHA less than 130 over
80 high risk HF reduced EF GDMT ACE inhibitor or ARNI beta blocker carvedilol metoprolol bisoprolol MRA spironolactone SGLT2i
dapagliflozin empagliflozin diuretic volume AFib CHA2DS2-VASc score 0 male 1 female no anticoag 1 male 2 female consider 2 male 3 female
anticoag DOAC apixaban rivaroxaban warfarin INR 2-3.
Endocrine Diabetes Thyroid
Description: T2DM first line metformin plus lifestyle if ASCVD HF CKD add SGLT2i or GLP-1 RA regardless A1c eGFR GLP-1 RA
contraindicated medullary thyroid carcinoma MEN2 SGLT2i mechanism proximal tubule glucosuria CV renal benefit hypothyroidism
levothyroxine 1.6 mcg per kg empty stomach 30-60 min before breakfast 4 hr calcium iron hyperthyroidism methimazole first line PTU first
trimester beta blocker propranolol iodine 1 hr after antithyroid agranulocytosis fever sore throat.
GU Renal UTI Contraception
Description: UTI uncomplicated cystitis nitrofurantoin 100 BID 5 days TMP-SMX 3 days if resistance less than 20 percent fosfomycin single dose
avoid FQ first line pyelo cipro 7 days if resistance less than 10 percent TMP-SMX 14 days ceftriaxone 1 dose then oral nitrofurantoin fosfomycin
NOT for pyelo contraception combined OCP contraindicated smoker greater than 35 HTN migraine with aura VTE breast cancer WHO Category
4.
Psych Mental Health Wellness
Description: Depression PHQ-9 SSRI sertraline escitalopram first line plus CBT psychotherapy black box suicide young anxiety GAD SSRI
SNRI plus CBT benzo short term only dependence smoking cessation 5As Ask Advise Assess Assist Arrange NRT varenicline bupropion
behavioral counseling.
Health Promotion Screening
Description: Osteoporosis DEXA women greater than 65 men greater than 70 T score less than -2.5 bisphosphonate alendronate calcium
vitamin D weight bearing prostate PSA shared decision 55-69 USPSTF MMR 12-15 months second dose 4-6 years live attenuated melanoma
ABCDE Asymmetry Border irregular Color variegated Diameter greater than 6 mm Evolving microcytic anemia MCV less than 80 iron deficiency
thalassemia lead chronic disease ferritin TIBC.
Page 1 - AANP 105Q 2026/2027
,Question 1: Q1: Centor sore throat?
A. Fever exudate tender anterior cervical LAD absence cough age scoring
B. Only fever
C. Only cough
D. No criteria
CORRECT ANSWER: A. Fever exudate tender anterior cervical LAD absence cough age scoring
RATIONALE:
Centor McIsaac fever exudate tender anterior cervical LAD absence cough age scoring guides GAS testing.
Question 2: Q2: AOM adult first line?
A. No antibiotics always
B. Only cipro
C. Amoxicillin 500 TID 875 BID first line doxy macrolide if penicillin allergy
D. Only IV vanco
CORRECT ANSWER: C. Amoxicillin 500 TID 875 BID first line doxy macrolide if penicillin allergy
RATIONALE:
AOM first line amoxicillin 500 TID 875 BID 5-7 days penicillin allergy doxy azithro pain control.
Question 3: Q3: CAP outpatient healthy?
A. Meropenem outpatient
B. Vanco outpatient
C. Gentamicin
D. Amoxicillin 1 g TID or doxy or azithro if resistance less than 25 percent
CORRECT ANSWER: D. Amoxicillin 1 g TID or doxy or azithro if resistance less than 25 percent
RATIONALE:
CAP outpatient no comorbidities amoxicillin 1 g TID or doxy or azithro if resistance less than 25 percent.
Question 4: Q4: Asthma controller?
A. LABA alone
B. ICS low dose first line persistent add LABA if not controlled never LABA alone
C. SABA alone persistent
D. No controller
CORRECT ANSWER: B. ICS low dose first line persistent add LABA if not controlled never LABA alone
RATIONALE:
Asthma stepwise low dose ICS first line persistent add LABA if not controlled never LABA alone.
Question 5: Q5: COPD exacerbation?
A. SABA SAMA albuterol ipratropium steroids 40 mg prednisone 5 days antibiotics if purulent
B. Only high flow O2 100 percent
C. Only antibiotics
D. No treatment
CORRECT ANSWER: A. SABA SAMA albuterol ipratropium steroids 40 mg prednisone 5 days antibiotics if purulent
RATIONALE:
COPD exacerbation SABA SAMA bronchodilators steroids prednisone 40 mg 5 days antibiotics if purulent SpO2 88-92.
Question 6: Q6: HTN target?
A. No target
B. Less than 180 over 110
C. Less than 140 over 90 general less than 150 over 90 greater than 60 without DM CKD ACC AHA less than 130 over 80
D. Less than 100 over 60
CORRECT ANSWER: C. Less than 140 over 90 general less than 150 over 90 greater than 60 without DM CKD ACC AHA less
than 130 over 80
RATIONALE:
JNC8 general less than 140/90 less than 150/90 if greater than 60 without DM CKD ACC AHA less than 130/80.
Question 7: Q7: HFrEF GDMT?
A. Only diuretic alone
B. Only digoxin
C. No treatment
D. ACE or ARNI beta blocker carvedilol metoprolol bisoprolol MRA SGLT2i
CORRECT ANSWER: D. ACE or ARNI beta blocker carvedilol metoprolol bisoprolol MRA SGLT2i
RATIONALE:
HFrEF GDMT ACE or ARNI beta blocker carvedilol metoprolol bisoprolol MRA SGLT2i dapa empagliflozin diuretic volume.
Page 2 - AANP 105Q 2026/2027
, Page 3 - AANP 105Q 2026/2027
