T2 EX4 L1 (PHARM. PARKINSON'S) (FOX) EXAM WITH COMPLETE
SOLUTIONS 100% VERIFIED!!!!! ALREADY GRADED A+
T/F: GABA inhibitory. - (answer)True
Describe Parkinson's disease (in caveperson) - (answer)Too much GABA -> GABA inhibitory -> Loss of
motor function, neurological function
*know this*
D1 receptor family constituents? (two) - (answer)D1 and D5
D2 receptor family constituents? (three) - (answer)D2, D3, D4
Which receptor family do dopaminergic anti-parkinson's drugs stimulate? - (answer)D2 receptor family
Explain Carbidopa-Levodopa - (answer)Facilitate diffusion across blood brain barrier, carbidopa inhibits
peripheral conversion of levodopa to dopamine; increased plasma levels, longer half-life
T/F: Take a high-protein meal with levodopa. - (answer)False; high protein meal mean bad absorption.
Gold-standard treatment for parkinson's? - (answer)Carbidopa/levodopa
T/F: Carbidopa-Levodopa works for the full duration of a patient's life with Parkinson's. - (answer)False;
as neurons die, storage and activity of neurotransmitters (dopamine) decrease.
T/F: Dopamine agonists are metabolized to toxic metabolites, and are therefore used sparingly in
patients with Parkinson's. - (answer)False; no toxic metabolites.
Non-ergot derived dopamine agonists? (three) - (answer)1. Ropinirole
2. Pramipexole
, T2 EX4 L1 (PHARM. PARKINSON'S) (FOX) EXAM WITH COMPLETE
SOLUTIONS 100% VERIFIED!!!!! ALREADY GRADED A+
3. Rotigotine
T/F: Pramipexole has a preferential affinity for the D3 receptor. - (answer)True
Why is pramipexole POSSIBLY neuroprotective? - (answer)Ability to scavenge free radicals
Ropinirole is selective for which receptor? - (answer)D2
What formulation is rotigotine? - (answer)Patch formulation
What enzyme is responsible for metabolizing dopamine? - (answer)MAO-B
T/F: Selegiline is an irreversible inhibitor of MAO-B. - (answer)True
Place in therapy for selegiline? - (answer)Not typically as monotherapy. usually adjunct to levodopa
Two MAOIs used in Parkinson's? - (answer)Selegiline
Rasagiline
T/F: Rasagiline CAN be used as monotherapy in advanced-stage PD. - (answer)False; only in early-stage
PD.
Contraindications for Safinamide (Xadago) (drugs, three classes)? - (answer)SNRIs, certain opioids, other
MAOIs
Role in therapy for safinamide? - (answer)Improve on time, decrease off time
SOLUTIONS 100% VERIFIED!!!!! ALREADY GRADED A+
T/F: GABA inhibitory. - (answer)True
Describe Parkinson's disease (in caveperson) - (answer)Too much GABA -> GABA inhibitory -> Loss of
motor function, neurological function
*know this*
D1 receptor family constituents? (two) - (answer)D1 and D5
D2 receptor family constituents? (three) - (answer)D2, D3, D4
Which receptor family do dopaminergic anti-parkinson's drugs stimulate? - (answer)D2 receptor family
Explain Carbidopa-Levodopa - (answer)Facilitate diffusion across blood brain barrier, carbidopa inhibits
peripheral conversion of levodopa to dopamine; increased plasma levels, longer half-life
T/F: Take a high-protein meal with levodopa. - (answer)False; high protein meal mean bad absorption.
Gold-standard treatment for parkinson's? - (answer)Carbidopa/levodopa
T/F: Carbidopa-Levodopa works for the full duration of a patient's life with Parkinson's. - (answer)False;
as neurons die, storage and activity of neurotransmitters (dopamine) decrease.
T/F: Dopamine agonists are metabolized to toxic metabolites, and are therefore used sparingly in
patients with Parkinson's. - (answer)False; no toxic metabolites.
Non-ergot derived dopamine agonists? (three) - (answer)1. Ropinirole
2. Pramipexole
, T2 EX4 L1 (PHARM. PARKINSON'S) (FOX) EXAM WITH COMPLETE
SOLUTIONS 100% VERIFIED!!!!! ALREADY GRADED A+
3. Rotigotine
T/F: Pramipexole has a preferential affinity for the D3 receptor. - (answer)True
Why is pramipexole POSSIBLY neuroprotective? - (answer)Ability to scavenge free radicals
Ropinirole is selective for which receptor? - (answer)D2
What formulation is rotigotine? - (answer)Patch formulation
What enzyme is responsible for metabolizing dopamine? - (answer)MAO-B
T/F: Selegiline is an irreversible inhibitor of MAO-B. - (answer)True
Place in therapy for selegiline? - (answer)Not typically as monotherapy. usually adjunct to levodopa
Two MAOIs used in Parkinson's? - (answer)Selegiline
Rasagiline
T/F: Rasagiline CAN be used as monotherapy in advanced-stage PD. - (answer)False; only in early-stage
PD.
Contraindications for Safinamide (Xadago) (drugs, three classes)? - (answer)SNRIs, certain opioids, other
MAOIs
Role in therapy for safinamide? - (answer)Improve on time, decrease off time
