T2 EX4 L5 PT. 2 (SEIZURES + EPILEPSY PHARMACOTHERAPY)
(HASARA) NEW SET WITH COMPLETE SOLUTIONS 100% VERIFIED!!
MOA of carbamazepine? - (answer)Enhances inactivation of voltage-gated sodium channels
Place in therapy for carbamazepine? - (answer)Monotherapy or adjunctive therapy for focal and
generalized seizure types
Useful in comorbid *BIPOLAR DISORDER AND TRIGEMINAL NEURALGIA*
T/F: Carbamazepine should be avoided in absence seizures. - (answer)True
T/F: Carbamazepine should be avoided in pregnancy. - (answer)True
T/F: Carbamazepine should be avoided if within 14 days of taking a MAOI inhibitor. - (answer)True
T/F: Carbamazepine associated with increased risk of SJS/TEN with HLA-B*15:02 allele. - (answer)True
Brand name carbamazepine? - (answer)Tegretol
Side effects associated with carbamazepine? (six) - (answer)1. Diplopia
2. Osteoporosis
3. Drowsiness/lethargy
4. Unsteadiness/dizziness
5. Bone marrow depression
6. *HYPONATREMIA*
Warnings associated with clonazepam? (four) - (answer)1. Profound CNS depression with concomitant
opioid use
2. CIs - acute narrow angle glaucoma, severe hepatic impairment
,T2 EX4 L5 PT. 2 (SEIZURES + EPILEPSY PHARMACOTHERAPY)
(HASARA) NEW SET WITH COMPLETE SOLUTIONS 100% VERIFIED!!
3. Tolerance/physiologic dependence
4. Withdrawal symptoms (including status epilepticus!!) on discontinuation.
T/F: Clonazepam safe for use in pregnancy. - (answer)False; avoid in pregnancy.
Place in therapy for clonazepam? - (answer)Monotherapy or adjunctive therapy for LGS, akinetic,
myoclonic, AND absence seizures.
T/F: Avoid clonazepam in *mixed* seizure types. - (answer)True
Side effects associated with clonazepam? (six) - (answer)1. Sedation
2. Ataxia
3. Paradoxical reactions
4. Hypersalivation
5. Hirsutism
6. Ankle/facial edema
MOA of ethosuximide? - (answer)Inhibition of T-type calcium channels
Warnings associated with ethosuximide? (three) - (answer)1. Blood dyscrasias
2. Drug interactions
3. Contraindicated in succinimide allergy
MOA of clonazepam? - (answer)Potentiates GABA via binding to GABAa receptor
Brand name of ethosuximide? - (answer)Zarontin
, T2 EX4 L5 PT. 2 (SEIZURES + EPILEPSY PHARMACOTHERAPY)
(HASARA) NEW SET WITH COMPLETE SOLUTIONS 100% VERIFIED!!
Place in therapy for ethosuximide? - (answer)Monotherapy and adjunctive therapy for *absence
seizures*
Caution in hepatic/renal dysfunction
Avoid in mixed seizure types
Avoid in pregnancy
MOA of phenobarbital? - (answer)Potentiates GABA via binding to GABAa receptor
Place in therapy for phenobarbital? - (answer)Used in focal onset and generalized seizures (not FDA
approved)
Side effects associated with phenobarbital? (six) - (answer)1. CNS effects
2. *Paradoxical reactions*
3. GI effects
4. Rash
5. Cardiac effects (IV)
6. Behavioral changes
Warnings associated with phenobarbital? (two) - (answer)1. Drug interactions
2. Tolerance/physiologic dependence
MOA of phenytoin? - (answer)Enhances inactivation of voltage-gated sodium channels
Warnings associated with phenytoin? (two) - (answer)Drug interactions
Increased risk of SJS/TEN with HLA-B*15:02 allele
(HASARA) NEW SET WITH COMPLETE SOLUTIONS 100% VERIFIED!!
MOA of carbamazepine? - (answer)Enhances inactivation of voltage-gated sodium channels
Place in therapy for carbamazepine? - (answer)Monotherapy or adjunctive therapy for focal and
generalized seizure types
Useful in comorbid *BIPOLAR DISORDER AND TRIGEMINAL NEURALGIA*
T/F: Carbamazepine should be avoided in absence seizures. - (answer)True
T/F: Carbamazepine should be avoided in pregnancy. - (answer)True
T/F: Carbamazepine should be avoided if within 14 days of taking a MAOI inhibitor. - (answer)True
T/F: Carbamazepine associated with increased risk of SJS/TEN with HLA-B*15:02 allele. - (answer)True
Brand name carbamazepine? - (answer)Tegretol
Side effects associated with carbamazepine? (six) - (answer)1. Diplopia
2. Osteoporosis
3. Drowsiness/lethargy
4. Unsteadiness/dizziness
5. Bone marrow depression
6. *HYPONATREMIA*
Warnings associated with clonazepam? (four) - (answer)1. Profound CNS depression with concomitant
opioid use
2. CIs - acute narrow angle glaucoma, severe hepatic impairment
,T2 EX4 L5 PT. 2 (SEIZURES + EPILEPSY PHARMACOTHERAPY)
(HASARA) NEW SET WITH COMPLETE SOLUTIONS 100% VERIFIED!!
3. Tolerance/physiologic dependence
4. Withdrawal symptoms (including status epilepticus!!) on discontinuation.
T/F: Clonazepam safe for use in pregnancy. - (answer)False; avoid in pregnancy.
Place in therapy for clonazepam? - (answer)Monotherapy or adjunctive therapy for LGS, akinetic,
myoclonic, AND absence seizures.
T/F: Avoid clonazepam in *mixed* seizure types. - (answer)True
Side effects associated with clonazepam? (six) - (answer)1. Sedation
2. Ataxia
3. Paradoxical reactions
4. Hypersalivation
5. Hirsutism
6. Ankle/facial edema
MOA of ethosuximide? - (answer)Inhibition of T-type calcium channels
Warnings associated with ethosuximide? (three) - (answer)1. Blood dyscrasias
2. Drug interactions
3. Contraindicated in succinimide allergy
MOA of clonazepam? - (answer)Potentiates GABA via binding to GABAa receptor
Brand name of ethosuximide? - (answer)Zarontin
, T2 EX4 L5 PT. 2 (SEIZURES + EPILEPSY PHARMACOTHERAPY)
(HASARA) NEW SET WITH COMPLETE SOLUTIONS 100% VERIFIED!!
Place in therapy for ethosuximide? - (answer)Monotherapy and adjunctive therapy for *absence
seizures*
Caution in hepatic/renal dysfunction
Avoid in mixed seizure types
Avoid in pregnancy
MOA of phenobarbital? - (answer)Potentiates GABA via binding to GABAa receptor
Place in therapy for phenobarbital? - (answer)Used in focal onset and generalized seizures (not FDA
approved)
Side effects associated with phenobarbital? (six) - (answer)1. CNS effects
2. *Paradoxical reactions*
3. GI effects
4. Rash
5. Cardiac effects (IV)
6. Behavioral changes
Warnings associated with phenobarbital? (two) - (answer)1. Drug interactions
2. Tolerance/physiologic dependence
MOA of phenytoin? - (answer)Enhances inactivation of voltage-gated sodium channels
Warnings associated with phenytoin? (two) - (answer)Drug interactions
Increased risk of SJS/TEN with HLA-B*15:02 allele
