BSN 315 Medicinal Chemistry (Nightingale College) –
Questions With Accurate Solutions
Add to calendar
Play your way to mastery with fun games
Match Blocks Charms NEW
Practice questions for this set
Learn 1 /7 Study using Learn
% ionised = + 10^(pka-pH)
Choose an answer
Why is it important to understand drug
1 2 Example of amino acid with alcohol
solubility?
3 Henderson hasslebalch equation 4 Experiment to find partition co-efficient
Don't know?
, Terms in this set (45)
Why is it important to understand drug A drugs ability to dissolve in water and lipid membranes
solubility? will influence its uptake by cells
It ultimately determines its dosage form
Polar to non polar substances examples Water, ethanol, diethyl ether, chloroform, hexane
In order to be absorbed, what must the Cell membrane or blood brain barrier
drug be able to pass
What is partition co-efficient The ability of a solute to distribute itself between an
organic and aqueous phases
Experiment to find partition co-efficient A known amount of solute is added to an immiscible
solution of water and usually octanol
The amount that distributes into each layer is calculated
analytically by spectroscopy
How to calculate partition co-efficient Conc of solute in organic layer / Concentration of
solute in aqueous layer
P apparent equation P true x fraction unionised
How to calculate P true Mass in organic / mass in aqueous layer
Henderson hasslebalch equation % ionised = + 10^(pka-pH)
What does medical chemistry involve? The rational design and synthesis of new drugs
It focuses on how drugs bind with their receptors to
promote a biological response
Questions With Accurate Solutions
Add to calendar
Play your way to mastery with fun games
Match Blocks Charms NEW
Practice questions for this set
Learn 1 /7 Study using Learn
% ionised = + 10^(pka-pH)
Choose an answer
Why is it important to understand drug
1 2 Example of amino acid with alcohol
solubility?
3 Henderson hasslebalch equation 4 Experiment to find partition co-efficient
Don't know?
, Terms in this set (45)
Why is it important to understand drug A drugs ability to dissolve in water and lipid membranes
solubility? will influence its uptake by cells
It ultimately determines its dosage form
Polar to non polar substances examples Water, ethanol, diethyl ether, chloroform, hexane
In order to be absorbed, what must the Cell membrane or blood brain barrier
drug be able to pass
What is partition co-efficient The ability of a solute to distribute itself between an
organic and aqueous phases
Experiment to find partition co-efficient A known amount of solute is added to an immiscible
solution of water and usually octanol
The amount that distributes into each layer is calculated
analytically by spectroscopy
How to calculate partition co-efficient Conc of solute in organic layer / Concentration of
solute in aqueous layer
P apparent equation P true x fraction unionised
How to calculate P true Mass in organic / mass in aqueous layer
Henderson hasslebalch equation % ionised = + 10^(pka-pH)
What does medical chemistry involve? The rational design and synthesis of new drugs
It focuses on how drugs bind with their receptors to
promote a biological response
