BSN 315 Central Nervous System Pharmacology (CNS Drug Basics) – Questions & A+ Solutions

BSN 315 Central Nervous System Pharmacology (CNS
Drug Basics) – Questions & A+ Solutions

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Sweating, rigidity, myoclonus, hyperthermia. Interaction between MAOi, TCAs, SSRIs,
meperidine, dextromethorphan



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1 Serotonin syndrome 2 Properties of benzodiazepines



3 Withdrawal signs of benzodiazepines 4 Uses of lorazepam



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, Terms in this set (101)



Properties of benzodiazepines Bind to gamma subunit of GABA(A) complex to increase
frequecy of Cl- channel opening; no GABAmimetic
activity; BZ1 mediates sedation; BZ2 mediates
antianxiety and impairment of cognitive functions


Benzodiazepine drugs Alprazolam, diazepam, lorazepam, midazolam,
temazepam, oxazepam


Uses of alprazolam Anxiety, phobias, panic attacks




Uses of diazepam Anxiety, preop sedation, muscle relaxation, withdrawal
states


Uses of lorazepam Anxiety, preop sedation, status epilepticus


Uses of midazolam Preop sedation and anesthesia, anterograde amnesia


Uses of temazepam Sleep disorders


Uses of oxazepam Sleep disorder and anxiety


Pharmacokinetics of benzodiazepines Liver metabolized to active compounds except
oxazepam, temazepam, lorazepam; t1/2: diazepam >
lorazepam > alprazolam > temazepam > oxazepam >
midazolam


Uses of barbiturates Phenobarbital for seizures; thiopental for induction of
anesthesia