BSN Pharmacology Introduction & Safety Principles | WEEK 2
Quiz Questions With Answers and detailed Rationales
Question 1.
Which branch of pharmacology is concerned with the movement of drugs through the
body, including absorption, distribution, metabolism, and excretion?
A. Pharmacokinetics
B. Pharmacodynamics
C. Pharmacotherapeutics
D. Pharmacogenomics
Correct Answer: A. Pharmacokinetics
Explanation: Pharmacokinetics describes the ‘journey’ of the drug through the body,
specifically absorption, distribution, metabolism, and excretion (ADME).
Question 2.
When a drug is administered orally and is extensively metabolized by the liver before
reaching systemic circulation, this is known as:
A. Bioavailability
B. Therapeutic index
C. The first-pass effect
D. Drug protein binding
Correct Answer: C. The first-pass effect
Explanation: The first-pass effect occurs when a drug’s concentration is greatly reduced
by the liver before it enters the systemic circulation.
Question 3.
Which of the following describes a drug that binds to a receptor and triggers a biological
response identical to the natural ligand?
A. Antagonist
B. Partial antagonist
C. Agonist
D. Inhibitor
Correct Answer: C. Agonist
Explanation: An agonist is a molecule that binds to a receptor and activates it to produce
a biological response.
, Question 4.
A nurse is administering a medication with a narrow therapeutic index. What is the nurse’s
priority action?
A. Increase the dose to ensure efficacy
B. Monitor blood levels closely for toxicity
C. Administer the drug only as a PRN dose
D. Switch the drug to a generic brand
Correct Answer: B. Monitor blood levels closely for toxicity
Explanation: A narrow therapeutic index means there is a small margin between a
therapeutic dose and a toxic dose, requiring close serum level monitoring.
Question 5.
What is the primary site of drug excretion in the human body?
A. Lungs
B. Liver
C. Kidneys
D. Large Intestine
Correct Answer: C. Kidneys
Explanation: While some excretion occurs via other routes, the kidneys are the primary
organs responsible for drug elimination.
Question 6.
If a drug has a half-life of 4 hours, what percentage of the drug will remain in the body
after 8 hours?
A. 50%
B. 75%
C. 25%
D. 12.5%
Correct Answer: C. 25%
Explanation: After 4 hours (one half-life), 50% remains. After another 4 hours (two half-
lives), half of that 50% remains, which is 25%.
Question 7.
Which schedule of controlled substances includes drugs with a high potential for abuse but
have currently accepted medical uses, such as morphine?
A. Schedule II
B. Schedule I
C. Schedule III
D. Schedule IV
Correct Answer: A. Schedule II
Quiz Questions With Answers and detailed Rationales
Question 1.
Which branch of pharmacology is concerned with the movement of drugs through the
body, including absorption, distribution, metabolism, and excretion?
A. Pharmacokinetics
B. Pharmacodynamics
C. Pharmacotherapeutics
D. Pharmacogenomics
Correct Answer: A. Pharmacokinetics
Explanation: Pharmacokinetics describes the ‘journey’ of the drug through the body,
specifically absorption, distribution, metabolism, and excretion (ADME).
Question 2.
When a drug is administered orally and is extensively metabolized by the liver before
reaching systemic circulation, this is known as:
A. Bioavailability
B. Therapeutic index
C. The first-pass effect
D. Drug protein binding
Correct Answer: C. The first-pass effect
Explanation: The first-pass effect occurs when a drug’s concentration is greatly reduced
by the liver before it enters the systemic circulation.
Question 3.
Which of the following describes a drug that binds to a receptor and triggers a biological
response identical to the natural ligand?
A. Antagonist
B. Partial antagonist
C. Agonist
D. Inhibitor
Correct Answer: C. Agonist
Explanation: An agonist is a molecule that binds to a receptor and activates it to produce
a biological response.
, Question 4.
A nurse is administering a medication with a narrow therapeutic index. What is the nurse’s
priority action?
A. Increase the dose to ensure efficacy
B. Monitor blood levels closely for toxicity
C. Administer the drug only as a PRN dose
D. Switch the drug to a generic brand
Correct Answer: B. Monitor blood levels closely for toxicity
Explanation: A narrow therapeutic index means there is a small margin between a
therapeutic dose and a toxic dose, requiring close serum level monitoring.
Question 5.
What is the primary site of drug excretion in the human body?
A. Lungs
B. Liver
C. Kidneys
D. Large Intestine
Correct Answer: C. Kidneys
Explanation: While some excretion occurs via other routes, the kidneys are the primary
organs responsible for drug elimination.
Question 6.
If a drug has a half-life of 4 hours, what percentage of the drug will remain in the body
after 8 hours?
A. 50%
B. 75%
C. 25%
D. 12.5%
Correct Answer: C. 25%
Explanation: After 4 hours (one half-life), 50% remains. After another 4 hours (two half-
lives), half of that 50% remains, which is 25%.
Question 7.
Which schedule of controlled substances includes drugs with a high potential for abuse but
have currently accepted medical uses, such as morphine?
A. Schedule II
B. Schedule I
C. Schedule III
D. Schedule IV
Correct Answer: A. Schedule II
