Nursing Pharmacology
Nursing Pharmacology
Study online at https://quizlet.com/_ellre
1. Absorption the process by which drug molecules move from their site of administration to
the blood
2. Affinity the ability of some tissues to attract, accumulate and store drugs in high con-
centrations relative to other tissues
3. blood-brain barri- Blood vessels (capillaries) that selectively let certain substances enter the brain
er tissue and keep other substances out
4. diffusion process by which molecules tend to move from an area where they are more
concentrated to an area where they are less concentrated
5. distribution the transport of drugs throughout the body after they are absorbed
6. drug-protein com- formed when a drugh that binds reversibly to a plasma protein, particularly
plexes albumin, that makes the drug unavailable for distribution to its site of action
7. enterohepatic re- recycling of drugs and other substances by the circulation of bile through the
circulation intestine and liver
8. enzyme induction process by whick a drug increases the activity of the hepatic microsomal enzymes
9. excretion the process of removing substances from the body
10. first-pass effect mechanism whereby drugs are absorbed enter into the hepatic portal circulation
and are inactivated by the liver before they reach the general circulation
11. fetal-placental bar- special anatomic barrier that inhibits many chemicals and drugs from entering
rier the fetus
12. hepatic microso- as it relates to phamacotherapy, liver enzymes that metabolize drugs as well
mal enzyme sys- as nutrients and other endogenous substances, sometimes called the P-450
tem System
13. isozymes
1/8
, Nursing Pharmacology
Nursing Pharmacology
Study online at https://quizlet.com/_ellre
multiple similar forms of an enzyme that perform slightly different metabolic
functions
14. loading dose relatively large dose of a drug given at the beginning of treatment to rapidly
obtain a therapeutic response
15. maintenance dos- amount of drug that keeps the plasma drug concentration in the therapeutic
es range
16. metabolism the process used by the body to chemically change a drug molecule, also called
biotransformation
17. minimum effective amount of drug required to produce a therapeutic effect
concentration
18. pharmacokinetics study of drug movement throughout the body
19. plasma half-life the length of time required for the plasma concentration of a drug to decrease
by one half after administration
20. prodrugs drugs that become more active after they are metabolized
21. substrate drug that is metabolized by a CYP enzyme
22. therapeutic drug practice of monitoring plasma levels of drughs that have low safety profiles and
monitoring using the data to predict drugh action or toxicity
23. therapeutic range dosage that produces the desired effects of a drug
24. toxic concentra- level of drug that results in serious adverse effects
tion
25. agonist drug that activates a receptor and produces the same type of response as the
endogenous substance
2/8
Nursing Pharmacology
Study online at https://quizlet.com/_ellre
1. Absorption the process by which drug molecules move from their site of administration to
the blood
2. Affinity the ability of some tissues to attract, accumulate and store drugs in high con-
centrations relative to other tissues
3. blood-brain barri- Blood vessels (capillaries) that selectively let certain substances enter the brain
er tissue and keep other substances out
4. diffusion process by which molecules tend to move from an area where they are more
concentrated to an area where they are less concentrated
5. distribution the transport of drugs throughout the body after they are absorbed
6. drug-protein com- formed when a drugh that binds reversibly to a plasma protein, particularly
plexes albumin, that makes the drug unavailable for distribution to its site of action
7. enterohepatic re- recycling of drugs and other substances by the circulation of bile through the
circulation intestine and liver
8. enzyme induction process by whick a drug increases the activity of the hepatic microsomal enzymes
9. excretion the process of removing substances from the body
10. first-pass effect mechanism whereby drugs are absorbed enter into the hepatic portal circulation
and are inactivated by the liver before they reach the general circulation
11. fetal-placental bar- special anatomic barrier that inhibits many chemicals and drugs from entering
rier the fetus
12. hepatic microso- as it relates to phamacotherapy, liver enzymes that metabolize drugs as well
mal enzyme sys- as nutrients and other endogenous substances, sometimes called the P-450
tem System
13. isozymes
1/8
, Nursing Pharmacology
Nursing Pharmacology
Study online at https://quizlet.com/_ellre
multiple similar forms of an enzyme that perform slightly different metabolic
functions
14. loading dose relatively large dose of a drug given at the beginning of treatment to rapidly
obtain a therapeutic response
15. maintenance dos- amount of drug that keeps the plasma drug concentration in the therapeutic
es range
16. metabolism the process used by the body to chemically change a drug molecule, also called
biotransformation
17. minimum effective amount of drug required to produce a therapeutic effect
concentration
18. pharmacokinetics study of drug movement throughout the body
19. plasma half-life the length of time required for the plasma concentration of a drug to decrease
by one half after administration
20. prodrugs drugs that become more active after they are metabolized
21. substrate drug that is metabolized by a CYP enzyme
22. therapeutic drug practice of monitoring plasma levels of drughs that have low safety profiles and
monitoring using the data to predict drugh action or toxicity
23. therapeutic range dosage that produces the desired effects of a drug
24. toxic concentra- level of drug that results in serious adverse effects
tion
25. agonist drug that activates a receptor and produces the same type of response as the
endogenous substance
2/8
