Smaller, less active, less developed brain regions: frontal, parietal, temporal cortices. Anterior
cingulate, basal ganglia, cerebellum.
Suspected neurochemical deficiency with dopamine and norepinephrine dysregulation - Answers
ADHD in the brain
Symptons present across the lifespan and are:
hyperactivity and impulsivity
Symptoms frquently present in childhood. They can lead to poor work performance, failed
relationships, low frustration tolerance, anger, addiction. - Answers Symptoms of ADHD
Disorders found more often in patients suffering from this disorder:
Learning, conduct, oppositional defiant, mood, substance use, personality - Answers Cormorbidities
found in patients with ADHD
About 20% of patients who suffer from this disorder also present with depressive symptoms. Also
about 10 to 15% of patients with bipolar also suffer from this disorder: - Answers National Study
states ADHD
One of the most complicated comorbidities with ADHD is: _________ and you want to treat this first
prior to ADHD treatment - Answers Substance abuse
Diagnostic interview
Identify the illness that is most impairing
Prioritize treatment
Compaing patient and observer reports - Answers Addressing cormorbidities
When you identify that the patient has comorbidities make sure to then do this with the treatment
process. - Answers Prioritize treatment
Evidence
Duration of action
Daily schedule
Comorbidities
Other symptom targets
Patient preference
Family history
Risk of abuse - Answers Choosing a Medication
Established treatments:
psychostimulants (FDA approved as 1st line)
Atomoxetine (FDA approved as 1st line)
Alpha-2 agonists (mainly for impulsivity) - Answers Medication strategies for ADHD
Alpha-2 agonists (mainly for impulsivity) - Answers Guanfacine & Kapvay
2nds line treatment - Answers TCAs
Bupropion
First-line treatmnet for ADHD - Answers Stimulants
These alpha-2 agonists seem to be best for impulsivity and hyperactivity versus attention - Answers
guanfacine and Kapvay
These are used as second line treatmnets - Answers TCAs, bupropion, and modafinil
Omega 3, 6, and 9 fatty acids
Venlafaxine
Beta-blockers
Some SGA (adjunct, impulsivity) but mostly for impulse control. - Answers Potentially these for ADHD
treatment.
These drugs can actually be effective but due to side effects are not practical - Answers MAOIs
First synthesized in Germany in 1887
Available since 1930s for behavioral disorders in children
Efficacy well documented
High response rate-doesn't confirm diagnosis - Answers Stimulants
FDA classifies a substance as a __________________ if the nucleus accumbends is
activated/stimulated - Answers Psychostimulant
Cardiac considerations