ONS CHEMOTHERAPY IMMUNOTHERAPY CERTIFICATE NEW SET
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Define neoadjuvant therapy - (answer)Treatment is given prior to surgery to shrink the tumor
Define adjuvant therapy - (answer)Additional cancer treatment given after the primary treatment to
lower the risk that the cancer reoccur
3 subcategories of alkylating agents: - (answer)1. Nitrogen mustards
2. Platinum-based agents (do not possess an alkyl group but still termed alkylating agents as they work
similarly)
3. Nitrosoureas
Common alkylating agents: - (answer)Cyclophosphamide (Cytoxan)
Ifosfamide (Ifex)
Bendamustine (Treanda)
Common platinum-based agents: - (answer)Cisplatin (Platinol)
Carboplatin (Paraplatin)
What is unique about nitrosoureas agents? - (answer)Able to cross the blood-brain barrier; can be
effective in treating some brain tumors
Common nitrosoureas agents: - (answer)Carmustine (BiCNU)
Lomustine (CeeNu)
Streptozocin (Zanosar)
Hypersensitivity can occur with late doses of: - (answer)Carboplatin
These agents are typically categorized as highly emetogenic: - (answer)1. Alkylating agents
2. Nitrosoureas
,ONS CHEMOTHERAPY IMMUNOTHERAPY CERTIFICATE NEW SET
WITH 100% VERIFIED SOLUTIONS!!!! LATEST UPDATE!!!
Pre-administration labs for alkylating agents and nitrosoureas: - (answer)BUN
Creatinine
CBC w/ diff
What is the medication Mesna used for? - (answer)Bladder protectant with administration of
cyclophosphamide or ifosfamide
Instruct pts receiving ________ to avoid exposure to cold air and consuming cold fluids for 3-4 days
following treatment - (answer)Oxaliplatin
How do antimetabolites function? - (answer)By blocking DNA and RNA growth by interfering with
enzymes needed for normal cell metabolism
Antimetabolites work in the ___ phase. - (answer)S
Common side effects of antimetabolites: - (answer)Myelosuppression
GI toxicities
Photosensitivity
Hand-foot syndrome
Common antimetabolite drugs: - (answer)Azacitidine
Capecitabine
5-FU
Cytarabine
Decitabine
Methotrexate
, ONS CHEMOTHERAPY IMMUNOTHERAPY CERTIFICATE NEW SET
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The institute for Safe Medication Practices recommends what route of administration for vincristine? -
(answer)IV piggyback via gravity
Anthracycline antitumor abx work by: - (answer)Interfering with enzymes necessary for DNA to replicate
in ALL phases of the cell cycle
The two major classifications of antitumor antibiotics are: - (answer)Anthracyclines
Non-anthracyclines
Common anthracycline antitumor abx: - (answer)Daunorubicin
Doxorubicin
Epirubicin
Idarubicin
The antitumor abx ___________ is not an anthracycline, but has anthracycline-type properties. -
(answer)Mitoxantrone
Common non-anthracycline antitumor abx: - (answer)Actinomycin D
Mitomycin C
Bleomycin
Monitoring necessary with doxorubicin: - (answer)Vesicant --> extravasation
Cardiac function
Lifetime dose tracking (cardiotoxicity)
Lifetime dose of doxorubicin should not exceed: - (answer)550 mg/m^2
What cardiac protectant medication can be administered prior to doxorubicin? - (answer)Dexrazoxane
WITH 100% VERIFIED SOLUTIONS!!!! LATEST UPDATE!!!
Define neoadjuvant therapy - (answer)Treatment is given prior to surgery to shrink the tumor
Define adjuvant therapy - (answer)Additional cancer treatment given after the primary treatment to
lower the risk that the cancer reoccur
3 subcategories of alkylating agents: - (answer)1. Nitrogen mustards
2. Platinum-based agents (do not possess an alkyl group but still termed alkylating agents as they work
similarly)
3. Nitrosoureas
Common alkylating agents: - (answer)Cyclophosphamide (Cytoxan)
Ifosfamide (Ifex)
Bendamustine (Treanda)
Common platinum-based agents: - (answer)Cisplatin (Platinol)
Carboplatin (Paraplatin)
What is unique about nitrosoureas agents? - (answer)Able to cross the blood-brain barrier; can be
effective in treating some brain tumors
Common nitrosoureas agents: - (answer)Carmustine (BiCNU)
Lomustine (CeeNu)
Streptozocin (Zanosar)
Hypersensitivity can occur with late doses of: - (answer)Carboplatin
These agents are typically categorized as highly emetogenic: - (answer)1. Alkylating agents
2. Nitrosoureas
,ONS CHEMOTHERAPY IMMUNOTHERAPY CERTIFICATE NEW SET
WITH 100% VERIFIED SOLUTIONS!!!! LATEST UPDATE!!!
Pre-administration labs for alkylating agents and nitrosoureas: - (answer)BUN
Creatinine
CBC w/ diff
What is the medication Mesna used for? - (answer)Bladder protectant with administration of
cyclophosphamide or ifosfamide
Instruct pts receiving ________ to avoid exposure to cold air and consuming cold fluids for 3-4 days
following treatment - (answer)Oxaliplatin
How do antimetabolites function? - (answer)By blocking DNA and RNA growth by interfering with
enzymes needed for normal cell metabolism
Antimetabolites work in the ___ phase. - (answer)S
Common side effects of antimetabolites: - (answer)Myelosuppression
GI toxicities
Photosensitivity
Hand-foot syndrome
Common antimetabolite drugs: - (answer)Azacitidine
Capecitabine
5-FU
Cytarabine
Decitabine
Methotrexate
, ONS CHEMOTHERAPY IMMUNOTHERAPY CERTIFICATE NEW SET
WITH 100% VERIFIED SOLUTIONS!!!! LATEST UPDATE!!!
The institute for Safe Medication Practices recommends what route of administration for vincristine? -
(answer)IV piggyback via gravity
Anthracycline antitumor abx work by: - (answer)Interfering with enzymes necessary for DNA to replicate
in ALL phases of the cell cycle
The two major classifications of antitumor antibiotics are: - (answer)Anthracyclines
Non-anthracyclines
Common anthracycline antitumor abx: - (answer)Daunorubicin
Doxorubicin
Epirubicin
Idarubicin
The antitumor abx ___________ is not an anthracycline, but has anthracycline-type properties. -
(answer)Mitoxantrone
Common non-anthracycline antitumor abx: - (answer)Actinomycin D
Mitomycin C
Bleomycin
Monitoring necessary with doxorubicin: - (answer)Vesicant --> extravasation
Cardiac function
Lifetime dose tracking (cardiotoxicity)
Lifetime dose of doxorubicin should not exceed: - (answer)550 mg/m^2
What cardiac protectant medication can be administered prior to doxorubicin? - (answer)Dexrazoxane
