ANCC FNP BOARD EXAM / AANP FNP CERTIFICATION
NEWEST 2026 -2027 ACTUAL EXAM COMPLETE 200+
QUESTIONS AND CORRECT DETAILED ANSWERS
(VERIFIED ANSWERS) | ALREADY GRADED A+.
SECTION 1: INFECTIOUS DISEASE & IMMUNOLOGY
Question (Infectious Mononucleosis – Acute Management)
A young adult presents with a history of sore throat, enlarged posterior
cervical lymph nodes, and complaints of profound fatigue lasting several
months. During the acute phase, which recommendations should the nurse
practitioner provide? (Select all that apply.)
• Limit physical activity for 4 weeks.
• Avoid close contact.
• Avoid sharing toothbrushes and utensils.
• Treat symptoms with over-the-counter medication.
• Prescribe penicillin therapy.
Answer: Limit physical activity for 4 weeks; Avoid close contact; Avoid
sharing toothbrushes and utensils; Treat symptoms with over-the-counter
medication.
Rationale: The presentation is classic for infectious mononucleosis (Epstein-
Barr virus). Treatment is symptomatic (NSAIDs, hydration, rest) and includes
monitoring for splenomegaly/hepatomegaly (hence restricting physical
activity to prevent splenic rupture). The virus is transmitted via saliva (hence
avoiding sharing utensils/toothbrushes and close contact).
Amoxicillin/penicillin should be avoided because it can cause a severe
maculopapular rash in patients with mononucleosis.
1|Page
,Question (Vaccines for a 70-Year-Old with Risk Factors)
A 70-year-old male with a 40-year smoking history, type-2 diabetes, and no
known allergies presents for a routine physical. Which vaccines should the
nurse practitioner include in the plan of care? (Select all that apply.)
• Influenza vaccine.
• Pneumococcal vaccine.
• Zoster vaccine live.
• Meningococcal conjugate vaccine.
• Varicella vaccine.
Answer: Influenza vaccine; Pneumococcal vaccine; Zoster vaccine live.
Rationale: Adults ≥65 should receive the pneumococcal vaccine (PCV13 and
PPSV23 series) and an annual influenza vaccine. The zoster (shingles) vaccine
(RZV or ZVL) is recommended for adults ≥50 with a history of chickenpox.
Varicella is not recommended for older adults who already had chickenpox.
Meningococcal conjugate is for younger populations (preteens, teens,
college students), not routine for older adults.
Question (Prostate Cancer Screening for High-Risk Male)
A 46-year-old African American male without a family history of prostate
cancer presents for an annual physical. Which screenings are recommended
for this patient? (Select all that apply.)
• Prostate-specific antigen (PSA) test.
• Computerized tomography (CT) scan.
• Digital rectal examination (DRE).
• Colonoscopy.
2|Page
, • Ultrasound.
Answer: Prostate-specific antigen (PSA) test; Digital rectal examination
(DRE).
Rationale: The American Cancer Society recommends that men at high risk
for prostate cancer (including African Americans) begin testing with PSA and
DRE at age 45. CT scans and ultrasounds are diagnostic tools for staging, not
screening. Colonoscopy screens for colorectal cancer, not prostate.
Question (Inflammatory Reaction to Strep Infection)
What is the inflammatory reaction to a streptococcal infection that may
affect the heart, joints, and brain?
• Peritonsillar abscess.
• Post-streptococcal glomerulonephritis.
• Acute rheumatic fever.
• Scarlet fever.
Answer: Acute rheumatic fever.
Rationale: Acute rheumatic fever is an autoimmune, inflammatory sequela
of group A streptococcal pharyngitis that can affect the heart (carditis), joints
(arthritis), and brain (Sydenham's chorea). Post-streptococcal
glomerulonephritis affects the kidneys. Scarlet fever is the exanthematous
rash. Peritonsillar abscess is a localized suppurative complication.
Question (Anemia and Fall Risk in the Elderly)
A 67-year-old patient with anemia presents for a follow-up. Which question
is most relevant to the increased risk associated with this condition?
• "Are you sleeping well?"
• "Have you recently fallen?"
3|Page
, • "Has your appetite decreased?"
• "Have you had any unexplained pain in your calves?"
Answer: "Have you recently fallen?"
Rationale: Anemia causes fatigue, weakness, dizziness, and orthostatic
hypotension, significantly increasing fall risk in the elderly. While sleep and
appetite may be affected, the direct safety concern is fall-related injury.
Question (Sickle-Cell Anemia – Diagnostic Findings)
A 6-month-old infant with normocytic hemolytic anemia has electrophoresis
results showing hemoglobin S with a 20% concentration of hemoglobin F
(fetal hemoglobin). Which diagnosis is confirmed?
• Aplastic anemia.
• Hemolytic anemia.
• Sickle-cell anemia.
• Thalassemia major.
Answer: Sickle-cell anemia.
Rationale: The presence of hemoglobin S on electrophoresis confirms sickle-
cell disease. The elevated fetal hemoglobin (HbF) is a compensatory
mechanism seen in infants with sickle-cell anemia. Thalassemia major
presents with non-hemolytic anemia and appears later in the first two years
of life.
Question (Tinea Corporis Treatment)
Which medication is used to treat tinea corporis (ringworm)?
• Erythromycin.
• Mupirocin.
4|Page
NEWEST 2026 -2027 ACTUAL EXAM COMPLETE 200+
QUESTIONS AND CORRECT DETAILED ANSWERS
(VERIFIED ANSWERS) | ALREADY GRADED A+.
SECTION 1: INFECTIOUS DISEASE & IMMUNOLOGY
Question (Infectious Mononucleosis – Acute Management)
A young adult presents with a history of sore throat, enlarged posterior
cervical lymph nodes, and complaints of profound fatigue lasting several
months. During the acute phase, which recommendations should the nurse
practitioner provide? (Select all that apply.)
• Limit physical activity for 4 weeks.
• Avoid close contact.
• Avoid sharing toothbrushes and utensils.
• Treat symptoms with over-the-counter medication.
• Prescribe penicillin therapy.
Answer: Limit physical activity for 4 weeks; Avoid close contact; Avoid
sharing toothbrushes and utensils; Treat symptoms with over-the-counter
medication.
Rationale: The presentation is classic for infectious mononucleosis (Epstein-
Barr virus). Treatment is symptomatic (NSAIDs, hydration, rest) and includes
monitoring for splenomegaly/hepatomegaly (hence restricting physical
activity to prevent splenic rupture). The virus is transmitted via saliva (hence
avoiding sharing utensils/toothbrushes and close contact).
Amoxicillin/penicillin should be avoided because it can cause a severe
maculopapular rash in patients with mononucleosis.
1|Page
,Question (Vaccines for a 70-Year-Old with Risk Factors)
A 70-year-old male with a 40-year smoking history, type-2 diabetes, and no
known allergies presents for a routine physical. Which vaccines should the
nurse practitioner include in the plan of care? (Select all that apply.)
• Influenza vaccine.
• Pneumococcal vaccine.
• Zoster vaccine live.
• Meningococcal conjugate vaccine.
• Varicella vaccine.
Answer: Influenza vaccine; Pneumococcal vaccine; Zoster vaccine live.
Rationale: Adults ≥65 should receive the pneumococcal vaccine (PCV13 and
PPSV23 series) and an annual influenza vaccine. The zoster (shingles) vaccine
(RZV or ZVL) is recommended for adults ≥50 with a history of chickenpox.
Varicella is not recommended for older adults who already had chickenpox.
Meningococcal conjugate is for younger populations (preteens, teens,
college students), not routine for older adults.
Question (Prostate Cancer Screening for High-Risk Male)
A 46-year-old African American male without a family history of prostate
cancer presents for an annual physical. Which screenings are recommended
for this patient? (Select all that apply.)
• Prostate-specific antigen (PSA) test.
• Computerized tomography (CT) scan.
• Digital rectal examination (DRE).
• Colonoscopy.
2|Page
, • Ultrasound.
Answer: Prostate-specific antigen (PSA) test; Digital rectal examination
(DRE).
Rationale: The American Cancer Society recommends that men at high risk
for prostate cancer (including African Americans) begin testing with PSA and
DRE at age 45. CT scans and ultrasounds are diagnostic tools for staging, not
screening. Colonoscopy screens for colorectal cancer, not prostate.
Question (Inflammatory Reaction to Strep Infection)
What is the inflammatory reaction to a streptococcal infection that may
affect the heart, joints, and brain?
• Peritonsillar abscess.
• Post-streptococcal glomerulonephritis.
• Acute rheumatic fever.
• Scarlet fever.
Answer: Acute rheumatic fever.
Rationale: Acute rheumatic fever is an autoimmune, inflammatory sequela
of group A streptococcal pharyngitis that can affect the heart (carditis), joints
(arthritis), and brain (Sydenham's chorea). Post-streptococcal
glomerulonephritis affects the kidneys. Scarlet fever is the exanthematous
rash. Peritonsillar abscess is a localized suppurative complication.
Question (Anemia and Fall Risk in the Elderly)
A 67-year-old patient with anemia presents for a follow-up. Which question
is most relevant to the increased risk associated with this condition?
• "Are you sleeping well?"
• "Have you recently fallen?"
3|Page
, • "Has your appetite decreased?"
• "Have you had any unexplained pain in your calves?"
Answer: "Have you recently fallen?"
Rationale: Anemia causes fatigue, weakness, dizziness, and orthostatic
hypotension, significantly increasing fall risk in the elderly. While sleep and
appetite may be affected, the direct safety concern is fall-related injury.
Question (Sickle-Cell Anemia – Diagnostic Findings)
A 6-month-old infant with normocytic hemolytic anemia has electrophoresis
results showing hemoglobin S with a 20% concentration of hemoglobin F
(fetal hemoglobin). Which diagnosis is confirmed?
• Aplastic anemia.
• Hemolytic anemia.
• Sickle-cell anemia.
• Thalassemia major.
Answer: Sickle-cell anemia.
Rationale: The presence of hemoglobin S on electrophoresis confirms sickle-
cell disease. The elevated fetal hemoglobin (HbF) is a compensatory
mechanism seen in infants with sickle-cell anemia. Thalassemia major
presents with non-hemolytic anemia and appears later in the first two years
of life.
Question (Tinea Corporis Treatment)
Which medication is used to treat tinea corporis (ringworm)?
• Erythromycin.
• Mupirocin.
4|Page
