NUR 376 Applied Pathophysiology Exam 3 Comprehensive Re… 2026 Update • Verified Answers
✓ VERIFIED • 2026 UPDATE • 100% ACCURATE
NUR 376 Applied Pathophysiology Exam 3
Comprehensive Review 2026 UPDATE
Actual Exam Questions & Verified Answers
with Detailed Rationales
Document Type: Exam (Elaborations)
Academic Year:
Total Questions: 50 Multiple Choice
Includes: Correct Answers + Full Rationales
Status: Verified & Updated for 2026
Exam (Elaborations) • Actual Questions & Rationales Page 1
,NUR 376 Applied Pathophysiology Exam 3 Comprehensive Re… 2026 Update • Verified Answers
Questions & Verified Answers
1. Which hormone deficiency is primarily responsible for the manifestations of Diabetes
Insipidus?
A. Antidiuretic Hormone
B. Insulin
C. Aldosterone
D. Growth Hormone
Answer: A
Rationale: Diabetes Insipidus is caused by a deficiency of Antidiuretic Hormone (ADH) or a decreased renal
response to it, leading to excessive urination. Exam questions often test the ability to distinguish this concept
from closely related distractors, making a clear rationale essential for mastery. Applying this knowledge in
clinical settings supports safe, evidence-based practice and improves patient outcomes.
2. A patient with SIADH is most likely to exhibit which electrolyte imbalance?
A. Hypernatremia
B. Hypokalemia
C. Hyponatremia
D. Hypercalcemia
Answer: C
Rationale: SIADH involves excessive ADH, which causes water retention and dilutional hyponatremia. Exam
questions often test the ability to distinguish this concept from closely related distractors, making a clear
rationale essential for mastery. Applying this knowledge in clinical settings supports safe, evidence-based
practice and improves patient outcomes.
3. Which clinical finding is a hallmark of Cushing’s Syndrome?
A. Bronze skin pigmentation
B. Weight loss
C. Hypotension
D. Moon face and buffalo hump
Answer: D
Rationale: Cushing’s Syndrome is characterized by cortisol excess, which causes fat redistribution leading to a
moon face and buffalo hump. Applying this knowledge in clinical settings supports safe, evidence-based
practice and improves patient outcomes. This is an important clinical concept because selecting the correct
answer (D) requires understanding both the pathophysiology and the practical nursing implications.
Exam (Elaborations) • Actual Questions & Rationales Page 2
, NUR 376 Applied Pathophysiology Exam 3 Comprehensive Re… 2026 Update • Verified Answers
4. Addison’s disease is characterized by the insufficient production of which hormones?
A. Thyroid hormones
B. Epinephrine and Norepinephrine
C. Insulin and Glucagon
D. Cortisol and Aldosterone
Answer: D
Rationale: Addison’s disease is primary adrenal insufficiency involving both glucocorticoids (cortisol) and
mineralocorticoids (aldosterone). Applying this knowledge in clinical settings supports safe, evidence-based
practice and improves patient outcomes. This is an important clinical concept because selecting the correct
answer (D) requires understanding both the pathophysiology and the practical nursing implications.
5. In a patient with Primary Hypothyroidism, how would the lab results typically appear?
A. High TSH, High T4
B. Low TSH, High T4
C. Low TSH, Low T4
D. High TSH, Low T4
Answer: D
Rationale: In primary hypothyroidism, the thyroid gland fails, resulting in low T4; the pituitary compensates by
increasing TSH. This is an important clinical concept because selecting the correct answer (D) requires
understanding both the pathophysiology and the practical nursing implications. Recognizing this principle
allows the nurse to prioritize care, anticipate complications, and provide accurate patient education.
6. Exophthalmos (bulging eyes) is most commonly associated with which condition?
A. Graves’ Disease
B. Myxedema Coma
C. Hashimoto’s Thyroiditis
D. Pheochromocytoma
Answer: A
Rationale: Graves’ disease is a form of hyperthyroidism that often presents with exophthalmos due to
autoimmune inflammation of the extraocular tissues. Recognizing this principle allows the nurse to prioritize
care, anticipate complications, and provide accurate patient education. Exam questions often test the ability to
distinguish this concept from closely related distractors, making a clear rationale essential for mastery.
Exam (Elaborations) • Actual Questions & Rationales Page 3
✓ VERIFIED • 2026 UPDATE • 100% ACCURATE
NUR 376 Applied Pathophysiology Exam 3
Comprehensive Review 2026 UPDATE
Actual Exam Questions & Verified Answers
with Detailed Rationales
Document Type: Exam (Elaborations)
Academic Year:
Total Questions: 50 Multiple Choice
Includes: Correct Answers + Full Rationales
Status: Verified & Updated for 2026
Exam (Elaborations) • Actual Questions & Rationales Page 1
,NUR 376 Applied Pathophysiology Exam 3 Comprehensive Re… 2026 Update • Verified Answers
Questions & Verified Answers
1. Which hormone deficiency is primarily responsible for the manifestations of Diabetes
Insipidus?
A. Antidiuretic Hormone
B. Insulin
C. Aldosterone
D. Growth Hormone
Answer: A
Rationale: Diabetes Insipidus is caused by a deficiency of Antidiuretic Hormone (ADH) or a decreased renal
response to it, leading to excessive urination. Exam questions often test the ability to distinguish this concept
from closely related distractors, making a clear rationale essential for mastery. Applying this knowledge in
clinical settings supports safe, evidence-based practice and improves patient outcomes.
2. A patient with SIADH is most likely to exhibit which electrolyte imbalance?
A. Hypernatremia
B. Hypokalemia
C. Hyponatremia
D. Hypercalcemia
Answer: C
Rationale: SIADH involves excessive ADH, which causes water retention and dilutional hyponatremia. Exam
questions often test the ability to distinguish this concept from closely related distractors, making a clear
rationale essential for mastery. Applying this knowledge in clinical settings supports safe, evidence-based
practice and improves patient outcomes.
3. Which clinical finding is a hallmark of Cushing’s Syndrome?
A. Bronze skin pigmentation
B. Weight loss
C. Hypotension
D. Moon face and buffalo hump
Answer: D
Rationale: Cushing’s Syndrome is characterized by cortisol excess, which causes fat redistribution leading to a
moon face and buffalo hump. Applying this knowledge in clinical settings supports safe, evidence-based
practice and improves patient outcomes. This is an important clinical concept because selecting the correct
answer (D) requires understanding both the pathophysiology and the practical nursing implications.
Exam (Elaborations) • Actual Questions & Rationales Page 2
, NUR 376 Applied Pathophysiology Exam 3 Comprehensive Re… 2026 Update • Verified Answers
4. Addison’s disease is characterized by the insufficient production of which hormones?
A. Thyroid hormones
B. Epinephrine and Norepinephrine
C. Insulin and Glucagon
D. Cortisol and Aldosterone
Answer: D
Rationale: Addison’s disease is primary adrenal insufficiency involving both glucocorticoids (cortisol) and
mineralocorticoids (aldosterone). Applying this knowledge in clinical settings supports safe, evidence-based
practice and improves patient outcomes. This is an important clinical concept because selecting the correct
answer (D) requires understanding both the pathophysiology and the practical nursing implications.
5. In a patient with Primary Hypothyroidism, how would the lab results typically appear?
A. High TSH, High T4
B. Low TSH, High T4
C. Low TSH, Low T4
D. High TSH, Low T4
Answer: D
Rationale: In primary hypothyroidism, the thyroid gland fails, resulting in low T4; the pituitary compensates by
increasing TSH. This is an important clinical concept because selecting the correct answer (D) requires
understanding both the pathophysiology and the practical nursing implications. Recognizing this principle
allows the nurse to prioritize care, anticipate complications, and provide accurate patient education.
6. Exophthalmos (bulging eyes) is most commonly associated with which condition?
A. Graves’ Disease
B. Myxedema Coma
C. Hashimoto’s Thyroiditis
D. Pheochromocytoma
Answer: A
Rationale: Graves’ disease is a form of hyperthyroidism that often presents with exophthalmos due to
autoimmune inflammation of the extraocular tissues. Recognizing this principle allows the nurse to prioritize
care, anticipate complications, and provide accurate patient education. Exam questions often test the ability to
distinguish this concept from closely related distractors, making a clear rationale essential for mastery.
Exam (Elaborations) • Actual Questions & Rationales Page 3
