Expert Verifed Ace the Test
Intra-chamber pressures - ANSWER ✔✔RA: 2-8 mmHg
RV: 15-25 mmHg systolic; 2-8 mmHg diastolic
PA: 15-25 mmHg systolic; 8-14 mmHg diastolic
LA: 6-12 mmHg
LV: 110-130 mmHg systolic; 6-12 mmHg systolic
Aorta: 110-130 mmHg systolic; 70-80 mmHg diastolic
Cardiac Output (CO) - ANSWER ✔✔CO= HR x SV
CO= 4-8 L/min
HR=60-100
,SV= 60-100 mL
Cardiac output is the amount of blood ejected in L/min; measures tissue
perfusion/assessment of blood flow. Affected by body size, O2 demand,
metabolic rate.
Preload (filling/volume) - ANSWER ✔✔Right: CVP: 0-8 mmHg
Left: PAD: 8-14 mmHg; PAWP 6-12 mmHg
Preload is the amount of end diastolic stretch on the myocardial muscle
fibers. The relationship of volume in the chambers and the compliance of
the chambers; think of a balloon!
*Starling's Law: The greater the stretch during diastole, the greater the
force of contraction in systole and the greater the cardiac output (CO)*
Low preload: fluids
High preload: Diuretics, nitrates, morphine
Afterload (resistance) - ANSWER ✔✔Right: PVR (pulm vasc
resistance) 150-250
Left: SVR (systemic vasc resistance) 800-1200; MAP: 60-90
Afterload is the resistance the ventricles must overcome in order to eject
blood forward. BP, SVR (left), PVR (right).
, Low afterload: Vasopressors; levo, dopamine, neo, epi, vasopressin
[+alpha for vasoconstriction]
High afterload: Venodilators; nipride, captopril, flolan
[-alpha for vasodilation]
Contractility (squeeze) - ANSWER ✔✔SV: 60-100 ml/min
EF: >40%
Contractility is the inotropic state of the myocardium; depends on healthy
muscle, intact cardiac cell membrane and normal electrolyte balance
(Mg, K, Ca)
Increased: sympathetic stimulation (fight vs flight), vasoactive meds.
Decreased: myocardial hypoxia/ischemia, negative intropic medications.
Low contractility: Inotropes; dobutamine, milrinone
High contractility: antidysrhthmics; BB, Ca+ blockers.
Cardiac Index (CI) - ANSWER ✔✔CI= 2.0-4.0
To calculate CI; CI=CO (4-8)/BSA
Cardiac index is the cardiac output in relation to the body size;
assessment of blood flow.
Stroke volume (SV) - ANSWER ✔✔SV= 60-100 mL/beat
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