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UWorld NCLEX-RN® Pharmacology – Nursing Medication Questions & Exam Prep 2026

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Prepare for the NCLEX-RN® Pharmacology examination with nursing medication questions and pharmacology review material for 2026. This resource is designed to help nursing students strengthen knowledge of medications, pharmacological concepts, nursing considerations, and NCLEX®-style exam preparation. Ideal for students searching for UWorld NCLEX-RN® Pharmacology, NCLEX® pharmacology questions, nursing medication questions, pharmacology exam prep, NCLEX-RN® study materials, and nursing pharmacology review for 2026

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UWorldvnNCLEX-RNvnPharmacology


Naloxonevn-vncorrectvnanswer✔ ✔ (narcan)vnopioidvnantagonist

-counteractsvnthevneffectsvnofvnopioids/vnpost-opvnanesthesia/vnover-sedationvn
-shortvnhalflifevn(wearsvnoffvninvn1-2h)
-
importantvntovnassessvnrespiratoryvnstatusvnatvn1vnhvnpostvnadministrationvnandvn
performvnappropriatevnaction(s)



Opioidvnanalgesics:vnsidevneffectsvn-vncorrectvnanswer✔ ✔ sedation

hypotension/vnorthostaticvnhypotensionvn
N/Vvn(short-termvneffect)
constipationvn(long-termvneffect)
respiratoryvndepression


codeinevnisvnanvn-vncorrectvnanswer✔ ✔ opioid



______positionvnwillvndecreasevnnauseavn-vncorrectvnanswer✔ ✔
still,vnsupine
(anti-emeticvnmayvnbevnnecessaryvninitially)

,Opioidvnanalgesics:vnnursingvnindicationsvn-vncorrectvnanswer✔ ✔ -
monitorvnsedationvnlevel
-instructvnptvnnotvntovngetvnoutvnofvnbedvnunassistedvn
-administervnPRNvnstoolvnsofteners


Itvnisvnmostvnimportantvnforvnthevnnursevntovnmonitorvn_______vnwhenvnavnptvnisv
ntakingvnopioidvnanalgesics;vnnotifyvnthevnHCPvnifvnthevnpt:vnA.vn___________


__vnorvnB.vn_____________vn-vncorrectvnanswer✔ ✔ sedationvnlevel

A.vnfallsvnasleepvnduringvnconversation
B.vnhasvnminimalvnorvnnovnresponsevntovnverbalvnorvnphysicalvnstimuli


Ifvnthevnptvnfallsvnasleepvnduringvnconversation:vn-vncorrectvnanswer✔ ✔
monitorvnrespiratoryvnstatusvnandvnnotifyvnHCPvntovndecreasevnsedationvnbyv
n25-50%




(slightlyvndrowsyvnisvnacceptable/normal)


Ifvnptvnhasvnminimalvnorvnnovnresponsevntovnverbal/physicalvnstimuli:vn-
vncorrectvnanswer✔ ✔
stopvnsedation,vnconsidervnusingvnnaloxone,vnnotifyvnHCP,vnmonitorvnrespir
atoryvnstatus

,Ptsvnatvnhighvnriskvnforvnrespiratoryvndepressionvnassociatedvnw/vnopioidvnanalg
esics:vn-vncorrectvnanswer✔ ✔ -advancedvnage

-surgeryvnw/invn24vnh
-COPD/vnunderlyingvnpulmonaryvndisease
-smoking
-snoring
-obesity
-opiatevnnaive


IVvnhydromorphonevnshouldvnbevngivenvn_______,vnovervn______-
______vnminutesvn-vncorrectvnanswer✔ ✔ slowly,vn2-3vnminutes



HoldvnmorphinevnifvnRRvnisvnlessvnthanvn-vncorrectvnanswer✔ ✔ 12


PtvnprescribedvnIVvnPCA,vnbutvnstillvnhasvnavnlotvnofvnpain-vn-vncorrectvnanswer
✔ ✔ preformvnthoroughvnpainvnassessment


ExtendedvnreleasevnOxycodonevnorvnOxycontin,vnavnlong-
actingvnopioidvnanalgesic,vnisvngivenvnwhenvnimmediatevnreleasevnopioidsvnare
vninadequatevnforvnpainvnmanagement;vntheyvnshouldvnbevnadministeredvn____


______,vnevenvnifvnthevnptvndeniesvn________vn-vncorrectvnanswer✔ ✔
around-the-clock
painvn

, (effectivevnforvn12vnh;vnadministeredvn2xvndaily)
*tolerancevnandvndependencevnisvndevelopedvnandvnhighervndosesvnarevneventu
allyvnrequiredvntovnachievevntherapeuticvneffect


NSAIDsvn-vncorrectvnanswer✔ ✔ -naproxenvn(Aleve)

-ibuprofenvn(Advil)
-idomethacinvn(Tivorbex)
-ketorlacvn(Toradol)vn*potent*


ComplicationsvnassociatedvnwithvnNSAIDsvn-vncorrectvnanswer✔ ✔ -
GIvntoxicity:vndyspepsia,vnpepticvnulcers,vnpain,vnbleedingvn(reportvnblackvntar
ryvnstoolvnandvntakevnmedvnw/vnfood)


-
Nephrotoxicity:vn(associatedvnw/vnlongvntermvnuse;vncanvnleadvntovnAKIvnandvn
CKD)


-
HTNvnandvnHF:vnNSAIDsvncanvncausevnfluidvnretentionvnwhichvncanvnexacerb
atevnHF,vnHTN,vnandvnascites,vnorvnleadvntovnMI,vnorvnstroke

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August 18, 2026
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