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NCLEX® Pharmacology Questions with Rationales – Nursing Exam Prep & Study Guide 2026

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Prepare for the NCLEX® Pharmacology examination with practice questions and detailed rationales for 2026. This study resource is designed to help nursing students review essential pharmacology concepts, test their medication knowledge, understand the reasoning behind answers, and strengthen NCLEX® exam preparation. Ideal for students searching for NCLEX® pharmacology questions with rationales, pharmacology practice questions, nursing medication questions, NCLEX® exam prep, pharmacology study guides, and nursing exam review materials for 2026.

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NCLEXvnQuestions-Pharmacologyvn(withvnrationales)


Avnnursevnisvncaringvnforvnavnclientvnwithvnhyperparathyroidismvnandvnnotesvnth
atvnthevnclient'svnserumvncalciumvnlevelvnisvn13vnmg/dL.vnWhichvnmedicationvns
houldvnthevnnursevnpreparevntovnadministervnasvnprescribedvntovnthevnclient?
1.vnCalciumvnchloride
vn



2.vnCalciumvngluconate
vn



3.vnCalcitoninvn(Miacalcin)
vn



4.vnLargevndosesvnofvnvitaminvnDvn-vncorrectvnanswer✔ ✔
vn


3.vnCalcitoninvn(Miacalcin)
Rationale:
Thevnnormalvnserumvncalciumvnlevelvnisvn8.6vntovn10.0vnmg/dL.vnThisvnclientvnis
vnexperiencingvnhypercalcemia.vnCalciumvngluconatevnandvncalciumvnchlorid


evnarevnmedicationsvnusedvnforvnthevntreatmentvnofvntetany,vnwhichvnoccursvnasvn
avnresultvnofvnacutevnhypocalcemia.vnInvnhypercalcemia,vnlargevndosesvnofvnvit
aminvnDvnneedvntovnbevnavoided.vnCalcitonin,vnavnthyroidvnhormone,vndecrease
svnthevnplasmavncalciumvnlevelvnbyvninhibitingvnbonevnresorptionvnandvnloweri
ngvnthevnserumvncalciumvnconcentration.


Oralvnironvnsupplementsvnarevnprescribedvnforvnavn6-year-
oldvnchildvnwithvnironvndeficiencyvnanemia.vnThevnnursevninstructsvnthevnmothe
rvntovnadministervnthevnironvnwithvnwhichvnbestvnfoodvnitem?
1.vnMilk
vn



2.vnWater
vn

, 3.vnApplevnjuice
vn



4.vnOrangevnjuicevn-vncorrectvnanswer✔ ✔ 4.vnOrangevnjuice
vn



Rationale:
VitaminvnCvnincreasesvnthevnabsorptionvnofvnironvnbyvnthevnbody.vnThevnmother
vnshouldvnbevninstructedvntovnadministervnthevnmedication vnwithvnavncitrusvnfruit


vnorvnavnjuicevnthatvnisvnhighvninvnvitaminvnC.vnMilkvnmayvnaffectvnabsorptionvnof


vnthevniron.vnWatervnwillvnnotvnassistvninvnabsorption.vnOrangevnjuicevncontainsvn


avngreatervnamountvnofvnvitaminvnCvnthanvnapplevnjuice.


Salicylicvnacidvnisvnprescribedvnforvnavnclientvnwithvnavndiagnosisvnofvnpsoriasis.
vnThevnnursevnmonitorsvnthevnclient,vnknowingvnthatvnwhichvnofvnthevnfollowing


vnwouldvnindicatevnthevnpresencevnofvnsystemicvntoxicityvnfromvnthisvnmedicati


on?
1.vnTinnitus
vn



2.vnDiarrhea
vn



3.vnConstipation
vn



4.vnDecreasedvnrespirationsvn-vncorrectvnanswer✔ ✔ 1.vnTinnitus
vn



Rationale:
Salicylicvnacidvnisvnabsorbedvnreadilyvnthroughvnthevnskin,vnandvnsystemicvntox
icityvn(salicylism)vncanvnresult.vnSymptomsvnincludevntinnitus,vndizziness,vnhy
perpnea,vnandvnpsychologicalvndisturbances.vnConstipationvnandvndiarrheavna
revnnotvnassociatedvnwithvnsalicylism.

,Avnclientvnwithvnseverevnacnevnisvnseenvninvnthevnclinicvnandvnthevnhealthvncarevnp
rovidervn(HCP)vnprescribesvnisotretinoin.vnThevnnursevnreviewsvnthevnclient'svn
medicationvnrecordvnandvnwouldvncontactvnthevn(HCP)vnifvnthevnclientvnisvntakin
gvnwhichvnmedication?
1.vnVitaminvnA
vn



2.vnDigoxinvn(Lanoxin)
vn



3.vnFurosemidevn(Lasix)
vn



4.vnPhenytoinvn(Dilantin)vn-vncorrectvnanswer✔ ✔ 1.vnVitaminvnA
vn



Rationale:
IsotretinoinvnisvnavnmetabolitevnofvnvitaminvnAvnandvncanvnproducevngeneralize
dvnintensificationvnofvnisotretinoinvntoxicity.vnBecausevnofvnthevnpotentialvnforv
nincreased vntoxicity,vnvitaminvnAvnsupplements vnshouldvnbevndiscontinuedvnbe


forevnisotretinoinvntherapy.vnOptionsvn2,vn3,vnandvn4vnarevnnotvncontraindicated
vnwithvnthevnusevnofvnisotretinoin.




Thevnnursevnisvnapplyingvnavntopicalvncorticosteroidvntovnavnclientvnwithvneczem
a.vnThevnnursevnwouldvnmonitorvnforvnthevnpotentialvnforvnincreasedvnsystemicvn
absorptionvnofvnthevnmedicationvnifvnthevnmedicationvnwerevnbeingvnappliedvnt
ovnwhichvnofvnthevnfollowingvnbodyvnareas?
1.vnBack
vn



2.vnAxilla
vn



3.vnSolesvnofvnthevnfeet
vn



4.vnPalmsvnofvnthevnhandsvn-vncorrectvnanswer✔ ✔ 2.vnAxilla
vn



Rationale:

, Topicalvncorticosteroidsvncanvnbevnabsorbedvnintovnthevnsystemicvncirculation.
vnAbsorptionvnisvnhighervnfromvnregionsvnwherevnthevnskinvnisvnespeciallyvnper


meablevn(scalp,vnaxilla,vnface,vneyelids,vnneck,vnperineum,vngenitalia),vnandvnl
owervnfromvnregionsvninvnwhichvnpermeabilityvnisvnpoorvn(back,vnpalms,vnsoles
).


Thevnhealthvncarevnprovidervnhasvnprescribedvnsilvervnsulfadiazinevn(Silvaden
e)vnforvnthevnclientvnwithvnavnpartial-
thicknessvnburn,vnwhichvnhasvnculturedvnpositivevnforvngram-
negativevnbacteria.vnThevnnursevnisvnreinforcingvninformationvntovnthevnclientvn
aboutvnthevnmedication.vnWhichvnstatementvnmadevnbyvnthevnclientvnindicatesvn
avnlackvnofvnunderstandingvnaboutvnthevntreatments?
1.vn"Thevnmedicationvnisvnanvnantibacterial."
vn



2.vn"Thevnmedicationvnwillvnhelpvnhealvnthevnburn."
vn



3.vn"Thevnmedicationvnwillvnpermanentlyvnstainvnmyvnskin."
vn



vn4.vn"Thevnmedicationvnshouldvnbevnappliedvndirectlyvntovnthevnwound."vn-
vncorrectvnanswer✔ ✔
3.vn"Thevnmedicationvnwillvnpermanentlyvnstainvnmyvnskin."
Rationale:
Silvervnsulfadiazinevn(Silvadene)vnisvnanvnantibacterialvnthatvnhasvnavnbroadvnsp
ectrumvnofvnactivityvnagainstvngram-negativevnbacteria,vngram-
positivevnbacteria,vnandvnyeast.vnItvnisvnappliedvndirectlyvntovnthevnwoundvntovnas
sistvninvnhealing.vnItvndoesvnnotvnstainvnthevnskin.

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