NURS 615 EXAM 3 COMPREHENSIVE
REVIEW SHEET VERIFIED QUESTION BANK
●● Gout - therapy goals
Answer: Management of pain associated with acute attacks, lowering
uric acid levels, lifestyle management
●● Opioid FULL agonist
Answer: activate opioid receptor fully;
Heroin, morphine, codeine, methadone;
Affinity PLUS efficacy
●● Opioid PARTIAL agonist
Answer: activate opioid receptor to a lesser degree - you can increase
these drug doses but it usually does not help decrease the pain/effects.
Meds: Buprenorphine & tramadol.
Affinity but low efficacy
●● Opioid antagonist
Answer: bind to opioid receptors without activating them.
Naloxone (Narcan).
Affinity but no efficacy
,●● Gout caused by
Answer: Caused by alteration in purine metabolism, leads to uric acid
buildup.
Hyperuricemia and deposit crystals in joints and tissues
●● Allopurinol adverse effects
Answer: Hepatotoxicity, gout flair at initiation of therapy, skin rash,
multiple drug interactions
●● Gout LABS to check
Answer: LFT, BUN, Creatinine, Uric acid level, CBC - check these until
they are stable
●● Gout flair up meds
Answer: Colchicine, NSAIDs (naproxen is typical), and glucocorticoids
●● Colchicine adverse effects
Answer: GI - Diarrhea, N/V, Abdominal cramping; Anemia. Low dose is
preferable to high dose
●● Corticosteroids
, Answer: Hormones produced by adrenal cortex, affect almost all organs
in the body maintaining homeostasis, disease results from inadequate or
excess secretion
●● Corticosteroids
Answer: Decrease peripheral uptake of glucose, glucogenesis in liver
Decrease protein synthesis in muscle, lymph tissue, skin, bone
Lipolysis in fat tissue in extremities; lipogenesis in face & trunk
Decreased circulating eosinophils, lymphocytes, monocytes; increased
PMNs
Blocks generation of fever
Promotes gastric acid secretion; enhances urinary excretion
Decreased proliferation of fibroblasts in conn tissue; delay healin
Maintains normal contractility of skeletal & cardiac muscle
Increases osteoclastic activity; decreases osteoblastic activity
Maintains normal BP; increases response of arterioles to NE
Modulates emotional and perceptual function; essential for normal
arousal
●● Corticoidsteroid principles of Therapy
Answer: Risk to benefit should always be considered.
Short term use for self-limiting, acute conditions.
REVIEW SHEET VERIFIED QUESTION BANK
●● Gout - therapy goals
Answer: Management of pain associated with acute attacks, lowering
uric acid levels, lifestyle management
●● Opioid FULL agonist
Answer: activate opioid receptor fully;
Heroin, morphine, codeine, methadone;
Affinity PLUS efficacy
●● Opioid PARTIAL agonist
Answer: activate opioid receptor to a lesser degree - you can increase
these drug doses but it usually does not help decrease the pain/effects.
Meds: Buprenorphine & tramadol.
Affinity but low efficacy
●● Opioid antagonist
Answer: bind to opioid receptors without activating them.
Naloxone (Narcan).
Affinity but no efficacy
,●● Gout caused by
Answer: Caused by alteration in purine metabolism, leads to uric acid
buildup.
Hyperuricemia and deposit crystals in joints and tissues
●● Allopurinol adverse effects
Answer: Hepatotoxicity, gout flair at initiation of therapy, skin rash,
multiple drug interactions
●● Gout LABS to check
Answer: LFT, BUN, Creatinine, Uric acid level, CBC - check these until
they are stable
●● Gout flair up meds
Answer: Colchicine, NSAIDs (naproxen is typical), and glucocorticoids
●● Colchicine adverse effects
Answer: GI - Diarrhea, N/V, Abdominal cramping; Anemia. Low dose is
preferable to high dose
●● Corticosteroids
, Answer: Hormones produced by adrenal cortex, affect almost all organs
in the body maintaining homeostasis, disease results from inadequate or
excess secretion
●● Corticosteroids
Answer: Decrease peripheral uptake of glucose, glucogenesis in liver
Decrease protein synthesis in muscle, lymph tissue, skin, bone
Lipolysis in fat tissue in extremities; lipogenesis in face & trunk
Decreased circulating eosinophils, lymphocytes, monocytes; increased
PMNs
Blocks generation of fever
Promotes gastric acid secretion; enhances urinary excretion
Decreased proliferation of fibroblasts in conn tissue; delay healin
Maintains normal contractility of skeletal & cardiac muscle
Increases osteoclastic activity; decreases osteoblastic activity
Maintains normal BP; increases response of arterioles to NE
Modulates emotional and perceptual function; essential for normal
arousal
●● Corticoidsteroid principles of Therapy
Answer: Risk to benefit should always be considered.
Short term use for self-limiting, acute conditions.
