RODAK'S 6TH ED CHAPTER 35-42 REVIEW QUESTIONS AND ANSWERS

RODAK'S 6TH ED CHAPTER 35-42
REVIEW QUESTIONS AND ANSWERS
b.2Endothelial2cell2-
2What2intimal2cell2synthesizes2and2stores2von2Willebrand2factor2(VWF)?
a.2Smooth2muscle2cell2
b.2Endothelial2cell2
c.2Fibroblast2
d.2Platelet

c.2Tissue2factor2-
2What2subendothelial2structural2protein2triggers2coagulation2through2activation2of
2factor2VII?2
a.2Thrombomodulin2
b.2Nitric2oxide2
c.2Tissue2factor2
d.2Thrombin

b.2Fibrinogen2-
2What2coagulation2plasma2protein2should2be2assayed2when2platelets2fail2to2ag
gregate2properly?2
a.2Factor2VIII2
b.2Fibrinogen2
c.2Thrombin2
d.2Factor2X

d.2Carboxylates2the2factors2to2allow2calcium2binding2-
2What2is2the2primary2role2of2vitamin2K2for2the2prothrombin2group2factors?2
a.2Provides2a2surface2on2which2the2proteolytic2reactions2of2the2factors2occur2
b.2Protects2them2from2inappropriate2activation2by2compounds2such2as2thrombin
2
c.2Accelerates2the2binding2of2the2serine2proteases2and2their2cofactors2
d.2Carboxylates2the2factors2to2allow2calcium2binding

b.2Thrombin2proteolysis2of2fibrinogen2-
2What2is2the2source2of2prothrombin2fragment2F1.2?2
a.2Plasmin2proteolysis2of2fibrin2polymer2
b.2Thrombin2proteolysis2of2fibrinogen2
c.2Proteolysis2of2prothrombin2by2factor2Xa2d.2Plasmin2proteolysis2of2cross-
linked2fibrin

,d.2Factor2IXa,2factor2X2-
2What2serine2protease2forms2a2complex2with2factor2VIIIa,2and2what2is2the2sub
strate2of2this2complex?2
a.2Factor2VIIa,2factor2X2
b.2Factor2Va,2prothrombin2c.2Factor2Xa,2prothrombin2d.2Factor2IXa,2factor2X

b.2TPA2-2What2protein2secreted2by2endothelial2cells2activates2fibrinolysis?2
a.2Plasminogen2
b.2TPA2
c.2PAI-12
d.2TAFI

c.2APC2and2protein2S2-
2What2two2regulatory2proteins2form2a2complex2that2digests2activated2factors2V2
and2VIII?2
a.2TFPI2and2Xa2
b.2Antithrombin2and2protein2C2
c.2APC2and2protein2S2
d.2Thrombomodulin2and2plasmin

c.2Mediate2platelet2adhesion2and2serve2as2a2carrier2molecule2for2factor2VIII2-
2What2are2the2primary2roles2of2VWF?2
a.2Inhibit2excess2coagulation2and2activate2protein2C2
b.2Activate2plasmin2and2promote2lysis2of2fibrinogen2
c.2Mediate2platelet2adhesion2and2serve2as2a2carrier2molecule2for2factor2VIII2
d.2Mediate2platelet2aggregation2via2the2GP2IIb/IIIa2receptor

a.2The2liver2-2Most2coagulation2factors2are2synthesized2in:2
a.2The2liver2
b.2Monocytes2
c.2Endothelial2cells2
d.2Megakaryocytes

a.2Lead2to2the2formation2of2a2stable2fibrin2clot2-
2The2events2involved2in2secondary2hemostasis:2
a.2Lead2to2the2formation2of2a2stable2fibrin2clot2
b.2Usually2occur2independently2of2primary2hemostasis2
c.2Occur2in2a2random2fashion2
d.2Are2the2first2line2of2defense2against2blood2loss

d.2Factor2XIII2-
2Which2of2the2following2coagulation2factors2is2activated2by2thrombin2and2media
tes2the2stabilization2of2the2fibrin2clot?2
a.2Tissue2factor2
b.2Factor2VII2
c.2Factor2IX2

, 2d.2Factor2XIII

a.2AT,2TFPI2-
2Which2of2the2following2endogenous2plasma2inhibitors2is2(are)2important2for2the
2control2of2excessive2thrombin2generation?2
a.2AT,2TFPI2
b.2Platelet2factor242
c.2TAT,2F1.22
d.2a2and2b

a.2Trauma-induced2coagulopathy2-
2What2is2the2most2common2acquired2bleeding2disorder?2
a.2Trauma-induced2coagulopathy2
b.2Vitamin2K2deficiency2
c.2Liver2disease2
d.2VWD

d.2Central2nervous2system2bleed2-
2Which2is2a2typical2form2of2anatomic2bleeding?2
a.2Epistaxis2
b.2Menorrhagia2
c.2Hematemesis2
d.2Central2nervous2system2bleed

b.2Factor2VII2deficiency,2the2PT2-
2What2factor2becomes2deficient2early2in2liver2disease,2and2what2assay2does2its
2deficiency2prolong?
a.2Prothrombin2deficiency,2the2PT
b.2Factor2VII2deficiency,2the2PT
c.2FVIII2deficiency,2the2PTT
d.2Factor2IX2deficiency,2the2PTT

c.2Hypofibrinogenemia2-
2Which2of2the2following2conditions2causes2a2prolonged2thrombin2time?
a.2Antithrombin2deficiency
b.2Prothrombin2deficiency
c.2Hypofibrinogenemia
d.2Warfarin2therapy

b.2Subtype22B2-
2In2what2type2or2subtype2of2VWD2is2the2RIPA2test2result2positive2when2ristoc
etin2is2used2at2a2concentration2of2less2
than20.52mg/mL?
a.2Subtype22A
b.2Subtype22B
c.2Subtype22N