ROBBINS BASIC PATHOLOGY 10TH EDITION
EXAMS SET COMPLETE QUESTIONS AND
ANSWERS EXPERT VERIFIED
◉ types of integrins and their ligands
Answer: 1- leukocyte function associated antigen (LFA-1) expressed
on neutrophils, monocytes and naive, effector and memory T cells.
--> binds to ICAM 1/2 expressed on endothelium.
2- macrophage 1 antigen (MAC-1) on monocytes and DCs.
--> ICAM 1/2.
3- very late antigen (VLA-4) on monocytes and naive, effector and
memory T cells.
--> vascular cell adhesion molecule (VCAM-1)
4- α4β7 on monocytes and T-cells (gut homing naive, effector,
memory)
--> VCAM and MAdCAM-1 (mucosal vascular addressin cell adhesion
molecule) on endothelium in gut and gut associated lymphoid tissue.
◉ migration of leukocytes
, Answer: --> transmigration in post capillary venules; leukocytes
squeeze between cells at intercellular junctions.
--> chemokines produced in the extravascular tissue stimulate
leukocytes to travel along a chemical gradient.
--> platelet endothelial cell adhesion molecule 1 (PECAM-1) on
leukocytes and endothelial cells mediates the binding events needed
for leukocytes to traverse the endothelium.
--> Collagenase is secreted to pass through vascular basement
membrane.
note: the vessel wall is not injured during leukocyte transmigration.
◉ Chemotaxis
Answer: movement of leukocytes along a chemical gradient.
--> the chemo-attractants bind to G-protein coupled receptors on the
surface of leukocytes and induce polymerization of actin -->
increased amounts at the leading edge of the cell and localization of
myosin filaments at the back.
EXAMS SET COMPLETE QUESTIONS AND
ANSWERS EXPERT VERIFIED
◉ types of integrins and their ligands
Answer: 1- leukocyte function associated antigen (LFA-1) expressed
on neutrophils, monocytes and naive, effector and memory T cells.
--> binds to ICAM 1/2 expressed on endothelium.
2- macrophage 1 antigen (MAC-1) on monocytes and DCs.
--> ICAM 1/2.
3- very late antigen (VLA-4) on monocytes and naive, effector and
memory T cells.
--> vascular cell adhesion molecule (VCAM-1)
4- α4β7 on monocytes and T-cells (gut homing naive, effector,
memory)
--> VCAM and MAdCAM-1 (mucosal vascular addressin cell adhesion
molecule) on endothelium in gut and gut associated lymphoid tissue.
◉ migration of leukocytes
, Answer: --> transmigration in post capillary venules; leukocytes
squeeze between cells at intercellular junctions.
--> chemokines produced in the extravascular tissue stimulate
leukocytes to travel along a chemical gradient.
--> platelet endothelial cell adhesion molecule 1 (PECAM-1) on
leukocytes and endothelial cells mediates the binding events needed
for leukocytes to traverse the endothelium.
--> Collagenase is secreted to pass through vascular basement
membrane.
note: the vessel wall is not injured during leukocyte transmigration.
◉ Chemotaxis
Answer: movement of leukocytes along a chemical gradient.
--> the chemo-attractants bind to G-protein coupled receptors on the
surface of leukocytes and induce polymerization of actin -->
increased amounts at the leading edge of the cell and localization of
myosin filaments at the back.
