ONS CHEMOTHERAPY BIOTHERAPY EXAM
SCRIPT COMPREHENSIVE TEST BANK REVIEW
SHEET SOLVED QUESTIONS AND ANSWERS
◉ LESSON 1: Cell cycle. Answer: g1- increase in size
s- dna replicated
g2- cell enlarge and ready to divide
m phase- 2 hours
◉ mitosis. Answer: 4 stages, prophase, metaphase, anaphase,
telophase
-chemo targets certain points in the process
◉ apoptosis. Answer: programmed cell death
◉ hematopoiesis. Answer: formation of blood cells & how cells
differentiate
-myeloid: pre cells mature into RBCs, platelets and WBCs
-lymphoid: pre cells- mature into WBCS
◉ Principles of Biotherapy: p51-95 immunology. Answer: -defense
against foreign organisms, homeostasis (destroy aged cells),
surveillance
,◉ immune responses. Answer: innate: primary line of defense, non
specific, no memory
adaptive: secondary line of defence with specific memry
◉ cytokines. Answer: -effect growth and differentiation of WBC
-interferons, tumor necrosis factors, growth factos and interleukins
-small protein molecules released by cells throughout body providing
comunication between cells of the immune system
-regular antiboddy production and function of b cells
◉ vaccines for cancer prevention. Answer: -hep B prevents hepatitis
and hepatocellular carcinoma
-hpv vaccine
◉ filgrastim aka neupogen. Answer: SC or IV to derease infection in
patients with neutropenic fever associated with myelosuppressive
anticancer treatments for nonmyeloid malignancies
◉ tbo-filgramstim/ pegfilgrastim. Answer: reduce duration of
neutroenia in patients with non myeloid malignancies
◉ palifermin. Answer: IV to dec incidence of oral mucositis in
patients with hem malignanies before BMT
, ◉ sargramostim. Answer: aka leukine - patients with AML following
chemo to shorten neutrophil recovery and reduce incidence of
infection
◉ IFN gamma. Answer: reduce frequency and severity o infections
related to granulomatous disease
◉ aldeleukin. Answer: treat renal cell carcinoma and metastatic
melanoma
◉ oprevelkin. Answer: prevent severe thrombocytopenia and refuce
need for platelet transfusions in patients with nonmyeloid malig
◉ plerixafor. Answer: with filgrastim to mobilize hematopoeitc stem
cells for collection from peripheral blood of patients
◉ sipuleucel. Answer: castrate resistant prostate cancer
◉ rituximab. Answer: rituxan- treatment of relapsed or refractory low
grade follicular b cell NHL_ first line traetment in combo with chemo
in patients with response
-can treat severe rheumatoid arthritis
-can have severe reactions (hypotension, urticaria, angiodema,
hypoxia, rigors, dyspnea, chills, fever, nausea, rash, renal tox)
-premed with tylenol and benadryl
SCRIPT COMPREHENSIVE TEST BANK REVIEW
SHEET SOLVED QUESTIONS AND ANSWERS
◉ LESSON 1: Cell cycle. Answer: g1- increase in size
s- dna replicated
g2- cell enlarge and ready to divide
m phase- 2 hours
◉ mitosis. Answer: 4 stages, prophase, metaphase, anaphase,
telophase
-chemo targets certain points in the process
◉ apoptosis. Answer: programmed cell death
◉ hematopoiesis. Answer: formation of blood cells & how cells
differentiate
-myeloid: pre cells mature into RBCs, platelets and WBCs
-lymphoid: pre cells- mature into WBCS
◉ Principles of Biotherapy: p51-95 immunology. Answer: -defense
against foreign organisms, homeostasis (destroy aged cells),
surveillance
,◉ immune responses. Answer: innate: primary line of defense, non
specific, no memory
adaptive: secondary line of defence with specific memry
◉ cytokines. Answer: -effect growth and differentiation of WBC
-interferons, tumor necrosis factors, growth factos and interleukins
-small protein molecules released by cells throughout body providing
comunication between cells of the immune system
-regular antiboddy production and function of b cells
◉ vaccines for cancer prevention. Answer: -hep B prevents hepatitis
and hepatocellular carcinoma
-hpv vaccine
◉ filgrastim aka neupogen. Answer: SC or IV to derease infection in
patients with neutropenic fever associated with myelosuppressive
anticancer treatments for nonmyeloid malignancies
◉ tbo-filgramstim/ pegfilgrastim. Answer: reduce duration of
neutroenia in patients with non myeloid malignancies
◉ palifermin. Answer: IV to dec incidence of oral mucositis in
patients with hem malignanies before BMT
, ◉ sargramostim. Answer: aka leukine - patients with AML following
chemo to shorten neutrophil recovery and reduce incidence of
infection
◉ IFN gamma. Answer: reduce frequency and severity o infections
related to granulomatous disease
◉ aldeleukin. Answer: treat renal cell carcinoma and metastatic
melanoma
◉ oprevelkin. Answer: prevent severe thrombocytopenia and refuce
need for platelet transfusions in patients with nonmyeloid malig
◉ plerixafor. Answer: with filgrastim to mobilize hematopoeitc stem
cells for collection from peripheral blood of patients
◉ sipuleucel. Answer: castrate resistant prostate cancer
◉ rituximab. Answer: rituxan- treatment of relapsed or refractory low
grade follicular b cell NHL_ first line traetment in combo with chemo
in patients with response
-can treat severe rheumatoid arthritis
-can have severe reactions (hypotension, urticaria, angiodema,
hypoxia, rigors, dyspnea, chills, fever, nausea, rash, renal tox)
-premed with tylenol and benadryl
