NUR 5461 MODULE 4 ADVANCED
PATHOPHYSIOLOGY ASSESSMENT 2026
COMPLEX CLINICAL DECISION MAKING
COMPLETE QUESTIONS AND SOLUTIONS
GRADED A+
◉ treatment of peripheral neuropathy
drugs
Answer: tricyclic antidepressants- off-label
gabapentin and pregabalin- fda approved for post herpetic
neuralgia; preagablin also approved for diabetic neuropathy
duloxetine- fda approved
tapentadol- fda approved
tramadol and opiods- off label
topical agents
◉ rediculopathy
Answer: compression of spinal root as it exits spinal cord
◉ rediculopathy
,in older adults may result from
Answer: herniated disc
osteophyte
◉ radiculopathy
pain characteristics
Answer: pain may radiate down neck, back, arm or leg
has proximal arm weakness
◉ radiculopathy
neurologic examination may revel
Answer: motor and sensory defects
diminution of reflexes in the distribution of spinal roots
◉ radiculopathy
what may help with diagnosis
Answer: mri with contrast and lumbar puncture with cytology may
help
◉ radiculopathy
Acute Inflammatory Demyelinating Polyradiculoneuropathy
Answer: aka guillain barre syndrome
, treat acutely with plasma exchange or IV immunoglobulin
◉ radiculopathy
chronic inflammatory demyelinating polyradiculoneuropathy
Answer: is a from of AIDP and requres long term immunotherapy
◉ radiculopathy
patient with diabetes
Answer: may present with diabetic amyotrophy, a lumbosacral
polyradiculitis, and plexopathy
starts with subacute onset of severe neuropathic pain in the thighs,
often asymmetric, followed by proximal muscle weakness in the legs
and eventual atrophy
◉ Myopathy in peripheral neuropathies
Answer: characterized by proximal muscle weakness, wasting, and
diminished or absent reflexes
can be accompanied by an increase in muscle enzymes, the
myopathic pattern on electromyogram, and an abnormal muscle
biopsy
◉ polymyositis
PATHOPHYSIOLOGY ASSESSMENT 2026
COMPLEX CLINICAL DECISION MAKING
COMPLETE QUESTIONS AND SOLUTIONS
GRADED A+
◉ treatment of peripheral neuropathy
drugs
Answer: tricyclic antidepressants- off-label
gabapentin and pregabalin- fda approved for post herpetic
neuralgia; preagablin also approved for diabetic neuropathy
duloxetine- fda approved
tapentadol- fda approved
tramadol and opiods- off label
topical agents
◉ rediculopathy
Answer: compression of spinal root as it exits spinal cord
◉ rediculopathy
,in older adults may result from
Answer: herniated disc
osteophyte
◉ radiculopathy
pain characteristics
Answer: pain may radiate down neck, back, arm or leg
has proximal arm weakness
◉ radiculopathy
neurologic examination may revel
Answer: motor and sensory defects
diminution of reflexes in the distribution of spinal roots
◉ radiculopathy
what may help with diagnosis
Answer: mri with contrast and lumbar puncture with cytology may
help
◉ radiculopathy
Acute Inflammatory Demyelinating Polyradiculoneuropathy
Answer: aka guillain barre syndrome
, treat acutely with plasma exchange or IV immunoglobulin
◉ radiculopathy
chronic inflammatory demyelinating polyradiculoneuropathy
Answer: is a from of AIDP and requres long term immunotherapy
◉ radiculopathy
patient with diabetes
Answer: may present with diabetic amyotrophy, a lumbosacral
polyradiculitis, and plexopathy
starts with subacute onset of severe neuropathic pain in the thighs,
often asymmetric, followed by proximal muscle weakness in the legs
and eventual atrophy
◉ Myopathy in peripheral neuropathies
Answer: characterized by proximal muscle weakness, wasting, and
diminished or absent reflexes
can be accompanied by an increase in muscle enzymes, the
myopathic pattern on electromyogram, and an abnormal muscle
biopsy
◉ polymyositis
