HESI A2 Anatomy & Physiology Exam 2026-2027 [700
QUESTIONS AND ANSWERS ALREADY GRADED A+. 100%
Verified Solutions] | Updated Per Latest Elsevier HESI
Standards | Graded A+
This comprehensive study guide contains 700 verified questions and answers for
the HESI A2 Anatomy and Physiology Examination, covering all essential domains
including terminology, body systems, cellular biology, and organ functions.
Designed for nursing program applicants preparing for the HESI A2 entrance
exam, this resource reflects the latest 2026/2027 Elsevier HESI testing standards .
Each question is accompanied by detailed rationales to reinforce learning and
ensure exam readiness .
Abstract:
This document serves as a definitive preparation resource for the HESI A2
Anatomy & Physiology subtest, aligned with the latest 2026/2027 Elsevier HESI
Admission Assessment (A2) blueprint . The 700 verified questions are
systematically organized into core content areas reflecting the official HESI A2
A&P exam blueprint: General Terminology and Anatomical Position, Cellular
Biology (Mitosis/Meiosis), Integumentary System, Skeletal System, Muscular
System, Nervous System, Endocrine System, Cardiovascular System, Respiratory
System, Immune System, Digestive System, Urinary System, and Reproductive
System . Each question is meticulously crafted to mirror the exam's format and
difficulty, with answers graded A+ by subject matter experts. Detailed rationales
elucidate correct responses and explain common distractor traps, promoting
deep conceptual understanding . The guide emphasizes practical application
through scenario-based questions that simulate real-world nursing situations.
Updated to incorporate the latest evidence-based practices, this resource ensures
candidates are thoroughly prepared to achieve exam success. The HESI A2
Anatomy & Physiology subtest contains 30 multiple-choice questions with a 25-
minute time limit.
,Content Area Overview:
Content Area Questions Key Topics Weight
General Terminology Planes, directional terms,
and Anatomical 1-80 body cavities, regions, 11%
Position homeostasis
Cell organelles, mitosis
Cellular Biology
81-130 phases, meiosis, DNA, 7%
(Mitosis & Meiosis)
chromosomes
Integumentary Skin layers, glands, hair,
131-180 7%
System nails, melanin, functions
Bone types, structure, joints,
Skeletal System 181-240 axial/appendicular, bone 9%
marrow
Muscle types, contraction,
Muscular System 241-290 major muscles, tendons, 7%
fascia
CNS/PNS, neurons,
Nervous System 291-350 neurotransmitters, brain 9%
structures, reflexes
Glands, hormones, feedback
Endocrine System 351-400 loops, adrenal, pituitary, 7%
thyroid
,Content Area Questions Key Topics Weight
Heart chambers, vessels,
Cardiovascular
401-480 blood flow, blood 11%
System
components, conduction
Ventilation, gas exchange,
Respiratory System 481-530 alveoli, diaphragm, lung 7%
volumes
Lymphocytes, antibodies,
Immune System 531-570 lymph nodes, thymus, 6%
inflammation
Organs, peristalsis,
Digestive System 571-620 7%
absorption, enzymes, bile
Nephron, filtration, ADH,
Urinary System 621-660 kidney function, urine 6%
formation
Male/female anatomy,
Reproductive
661-700 hormones, gametes, 6%
System
fertilization
SECTION 1: GENERAL TERMINOLOGY AND ANATOMICAL POSITION
(Questions 1-80)
Question 1: Which of the following best describes the anatomical position?
A) Standing upright, facing away from the observer, upper extremities at the
body's sides, feet flat and directed outward, palms facing anteriorly
, B) Standing upright, facing the observer, upper extremities at the body's sides,
feet flat and directed forward, palms facing anteriorly
C) Standing upright, facing the observer, upper extremities at the body's sides,
feet flat and directed forward, palms facing posteriorly
D) Lying down, facing upward, arms crossed over the chest
Answer: B) Standing upright, facing the observer, upper extremities at the
body's sides, feet flat and directed forward, palms facing anteriorly
Rationale: The anatomical position is defined as standing erect with feet forward
and palms facing anteriorly (towards the front) with the thumbs facing outward .
This standardized position is the reference point for all directional terms in
anatomy.
Question 2: Which anatomical plane divides the body into right and left portions?
A) Coronal plane
B) Sagittal plane
C) Transverse plane
D) Frontal plane
Answer: B) Sagittal plane
Rationale: The sagittal plane divides the body into right and left portions . The
coronal/frontal plane divides the body into anterior and posterior halves, and the
transverse plane divides the body into superior and inferior portions .
Question 3: The term "proximal" refers to:
A) Farther from the midline
B) Closer to the point of attachment
C) Toward the front of the body
D) Toward the back of the body
Answer: B) Closer to the point of attachment
Rationale: "Proximal" means near the point of origin or attachment, opposite of
"distal" . This term is commonly used when referring to limb structures.
Question 4: Which plane divides the body into superior (top) and inferior
(bottom) portions?
QUESTIONS AND ANSWERS ALREADY GRADED A+. 100%
Verified Solutions] | Updated Per Latest Elsevier HESI
Standards | Graded A+
This comprehensive study guide contains 700 verified questions and answers for
the HESI A2 Anatomy and Physiology Examination, covering all essential domains
including terminology, body systems, cellular biology, and organ functions.
Designed for nursing program applicants preparing for the HESI A2 entrance
exam, this resource reflects the latest 2026/2027 Elsevier HESI testing standards .
Each question is accompanied by detailed rationales to reinforce learning and
ensure exam readiness .
Abstract:
This document serves as a definitive preparation resource for the HESI A2
Anatomy & Physiology subtest, aligned with the latest 2026/2027 Elsevier HESI
Admission Assessment (A2) blueprint . The 700 verified questions are
systematically organized into core content areas reflecting the official HESI A2
A&P exam blueprint: General Terminology and Anatomical Position, Cellular
Biology (Mitosis/Meiosis), Integumentary System, Skeletal System, Muscular
System, Nervous System, Endocrine System, Cardiovascular System, Respiratory
System, Immune System, Digestive System, Urinary System, and Reproductive
System . Each question is meticulously crafted to mirror the exam's format and
difficulty, with answers graded A+ by subject matter experts. Detailed rationales
elucidate correct responses and explain common distractor traps, promoting
deep conceptual understanding . The guide emphasizes practical application
through scenario-based questions that simulate real-world nursing situations.
Updated to incorporate the latest evidence-based practices, this resource ensures
candidates are thoroughly prepared to achieve exam success. The HESI A2
Anatomy & Physiology subtest contains 30 multiple-choice questions with a 25-
minute time limit.
,Content Area Overview:
Content Area Questions Key Topics Weight
General Terminology Planes, directional terms,
and Anatomical 1-80 body cavities, regions, 11%
Position homeostasis
Cell organelles, mitosis
Cellular Biology
81-130 phases, meiosis, DNA, 7%
(Mitosis & Meiosis)
chromosomes
Integumentary Skin layers, glands, hair,
131-180 7%
System nails, melanin, functions
Bone types, structure, joints,
Skeletal System 181-240 axial/appendicular, bone 9%
marrow
Muscle types, contraction,
Muscular System 241-290 major muscles, tendons, 7%
fascia
CNS/PNS, neurons,
Nervous System 291-350 neurotransmitters, brain 9%
structures, reflexes
Glands, hormones, feedback
Endocrine System 351-400 loops, adrenal, pituitary, 7%
thyroid
,Content Area Questions Key Topics Weight
Heart chambers, vessels,
Cardiovascular
401-480 blood flow, blood 11%
System
components, conduction
Ventilation, gas exchange,
Respiratory System 481-530 alveoli, diaphragm, lung 7%
volumes
Lymphocytes, antibodies,
Immune System 531-570 lymph nodes, thymus, 6%
inflammation
Organs, peristalsis,
Digestive System 571-620 7%
absorption, enzymes, bile
Nephron, filtration, ADH,
Urinary System 621-660 kidney function, urine 6%
formation
Male/female anatomy,
Reproductive
661-700 hormones, gametes, 6%
System
fertilization
SECTION 1: GENERAL TERMINOLOGY AND ANATOMICAL POSITION
(Questions 1-80)
Question 1: Which of the following best describes the anatomical position?
A) Standing upright, facing away from the observer, upper extremities at the
body's sides, feet flat and directed outward, palms facing anteriorly
, B) Standing upright, facing the observer, upper extremities at the body's sides,
feet flat and directed forward, palms facing anteriorly
C) Standing upright, facing the observer, upper extremities at the body's sides,
feet flat and directed forward, palms facing posteriorly
D) Lying down, facing upward, arms crossed over the chest
Answer: B) Standing upright, facing the observer, upper extremities at the
body's sides, feet flat and directed forward, palms facing anteriorly
Rationale: The anatomical position is defined as standing erect with feet forward
and palms facing anteriorly (towards the front) with the thumbs facing outward .
This standardized position is the reference point for all directional terms in
anatomy.
Question 2: Which anatomical plane divides the body into right and left portions?
A) Coronal plane
B) Sagittal plane
C) Transverse plane
D) Frontal plane
Answer: B) Sagittal plane
Rationale: The sagittal plane divides the body into right and left portions . The
coronal/frontal plane divides the body into anterior and posterior halves, and the
transverse plane divides the body into superior and inferior portions .
Question 3: The term "proximal" refers to:
A) Farther from the midline
B) Closer to the point of attachment
C) Toward the front of the body
D) Toward the back of the body
Answer: B) Closer to the point of attachment
Rationale: "Proximal" means near the point of origin or attachment, opposite of
"distal" . This term is commonly used when referring to limb structures.
Question 4: Which plane divides the body into superior (top) and inferior
(bottom) portions?
