HESI ENTRANCE EXAM QUESTIONS & ANSWERS 2026-2027 | COMPREHEN… EXAM
P R O F E S S I O N A L P R A C T I C E M AT E R I A L S
HESI Entrance Exam
Questions & Answers
2026-2027 |
Comprehensive Admission
Exam (Rationales)
Verified Answers Exam Ready With Rationales
254 QUESTIONS
DOCUMENT OVERVIEW
This document contains 254 comprehensive exam questions with correct answers and detailed
rationales, covering a wide range of health science topics. It serves as an essential resource for
students preparing for the HESI Entrance Exam, enabling effective study, review, and certification
preparation. The thorough explanations ensure a deep understanding of the material, making it ideal
for both individual and group learning.
CONTENTS
• Blood Types and Transfusion • Human Anatomy
• Muscle and Joint Anatomy • Endocrine System
• Reproductive System • Nervous System
• Cell Biology • Respiratory System
• Environmental Science • Chemical Properties and Reactions
Page 1
, • Medical Terminology • Genetics and Evolution
• Circulatory System • Digestive System
• Taxonomy and Classification • Vocabulary and Definitions
E XA M Q U EST I O N S
Q1 QUESTION 1 OF 254
a person with AB- blood should NOT receive blood from which other blood type?
CORRECT ANSWER
AB+
RATIONALE
AB- individuals lack the Rh factor and can develop antibodies against Rh-positive blood, making transfusion of
AB+ blood potentially life-threatening due to hemolytic reactions. Understanding blood type compatibility is
crucial for safe transfusions, emphasizing the importance of matching both ABO and Rh factors.
Q2 QUESTION 2 OF 254
Which blood type is regarded as the common donor?
CORRECT ANSWER
O-
RATIONALE
O- blood type is considered the universal donor due to the absence of A, B, and Rh antigens, minimizing the
risk of hemolytic reactions in recipients with varying blood types. This characteristic allows O- blood to be
transfused safely to patients of any blood group.
Q3 QUESTION 3 OF 254
T or F, epithelial tissue is vascular.
CORRECT ANSWER
False
Page 2
, RATIONALE
Epithelial tissue lacks blood vessels and is avascular, receiving nutrients through diffusion from underlying
connective tissue. This characteristic is essential for its role in protection, absorption, and secretion, allowing
it to maintain its integrity and function without direct blood supply.
Q4 QUESTION 4 OF 254
a person with type B blood has
CORRECT ANSWER
"B" antigens on their red blood cells
RATIONALE
Individuals with type B blood express B antigens on the surface of their erythrocytes, which distinguishes their
blood type and influences compatibility in transfusions. This antigenic property is critical for understanding
blood group interactions and potential immune responses during transfusion or organ transplantation.
Q5 QUESTION 5 OF 254
what is the body's earliest defense against invading bacteria?
CORRECT ANSWER
skin
RATIONALE
Skin acts as a physical barrier that prevents the entry of pathogens, including bacteria, while also providing
biochemical defenses through secretions that inhibit microbial growth. This primary line of defense is critical
in maintaining homeostasis and protecting internal tissues from infection.
Q6 QUESTION 6 OF 254
insulin is produced in the X and functions to X. . .
CORRECT ANSWER
pancreatic islets; metabolize macronutrients primarily through the absorption of glucose into the body's
cells
Page 3
, RATIONALE
Insulin, secreted by the pancreatic islets, facilitates the uptake of glucose into cells, thereby regulating blood
sugar levels and promoting the metabolism of carbohydrates, fats, and proteins. This key hormone plays a vital
role in energy homeostasis by enabling cellular access to glucose for energy production.
Q7 QUESTION 7 OF 254
what is an example of naturally acquired passive immunity?
CORRECT ANSWER
breastfeeding
RATIONALE
Breastfeeding provides infants with antibodies from maternal serum, offering immediate protection against
pathogens without requiring the infant's immune system to produce its own antibodies. This exemplifies
naturally acquired passive immunity, where immunity is transferred from mother to child through biological
processes.
Q8 QUESTION 8 OF 254
bacteria that need oxygen to survive are called?
CORRECT ANSWER
aerobic
RATIONALE
Bacteria classified as aerobic require oxygen for cellular respiration and energy production, utilizing oxygen as
the terminal electron acceptor in their metabolic processes. This characteristic distinguishes them from
anaerobic bacteria, which thrive in environments devoid of oxygen.
Q9 QUESTION 9 OF 254
what is the molar mass of calcium if its atomic mass is 40 amu?
CORRECT ANSWER
40 grams/mole
Page 4
P R O F E S S I O N A L P R A C T I C E M AT E R I A L S
HESI Entrance Exam
Questions & Answers
2026-2027 |
Comprehensive Admission
Exam (Rationales)
Verified Answers Exam Ready With Rationales
254 QUESTIONS
DOCUMENT OVERVIEW
This document contains 254 comprehensive exam questions with correct answers and detailed
rationales, covering a wide range of health science topics. It serves as an essential resource for
students preparing for the HESI Entrance Exam, enabling effective study, review, and certification
preparation. The thorough explanations ensure a deep understanding of the material, making it ideal
for both individual and group learning.
CONTENTS
• Blood Types and Transfusion • Human Anatomy
• Muscle and Joint Anatomy • Endocrine System
• Reproductive System • Nervous System
• Cell Biology • Respiratory System
• Environmental Science • Chemical Properties and Reactions
Page 1
, • Medical Terminology • Genetics and Evolution
• Circulatory System • Digestive System
• Taxonomy and Classification • Vocabulary and Definitions
E XA M Q U EST I O N S
Q1 QUESTION 1 OF 254
a person with AB- blood should NOT receive blood from which other blood type?
CORRECT ANSWER
AB+
RATIONALE
AB- individuals lack the Rh factor and can develop antibodies against Rh-positive blood, making transfusion of
AB+ blood potentially life-threatening due to hemolytic reactions. Understanding blood type compatibility is
crucial for safe transfusions, emphasizing the importance of matching both ABO and Rh factors.
Q2 QUESTION 2 OF 254
Which blood type is regarded as the common donor?
CORRECT ANSWER
O-
RATIONALE
O- blood type is considered the universal donor due to the absence of A, B, and Rh antigens, minimizing the
risk of hemolytic reactions in recipients with varying blood types. This characteristic allows O- blood to be
transfused safely to patients of any blood group.
Q3 QUESTION 3 OF 254
T or F, epithelial tissue is vascular.
CORRECT ANSWER
False
Page 2
, RATIONALE
Epithelial tissue lacks blood vessels and is avascular, receiving nutrients through diffusion from underlying
connective tissue. This characteristic is essential for its role in protection, absorption, and secretion, allowing
it to maintain its integrity and function without direct blood supply.
Q4 QUESTION 4 OF 254
a person with type B blood has
CORRECT ANSWER
"B" antigens on their red blood cells
RATIONALE
Individuals with type B blood express B antigens on the surface of their erythrocytes, which distinguishes their
blood type and influences compatibility in transfusions. This antigenic property is critical for understanding
blood group interactions and potential immune responses during transfusion or organ transplantation.
Q5 QUESTION 5 OF 254
what is the body's earliest defense against invading bacteria?
CORRECT ANSWER
skin
RATIONALE
Skin acts as a physical barrier that prevents the entry of pathogens, including bacteria, while also providing
biochemical defenses through secretions that inhibit microbial growth. This primary line of defense is critical
in maintaining homeostasis and protecting internal tissues from infection.
Q6 QUESTION 6 OF 254
insulin is produced in the X and functions to X. . .
CORRECT ANSWER
pancreatic islets; metabolize macronutrients primarily through the absorption of glucose into the body's
cells
Page 3
, RATIONALE
Insulin, secreted by the pancreatic islets, facilitates the uptake of glucose into cells, thereby regulating blood
sugar levels and promoting the metabolism of carbohydrates, fats, and proteins. This key hormone plays a vital
role in energy homeostasis by enabling cellular access to glucose for energy production.
Q7 QUESTION 7 OF 254
what is an example of naturally acquired passive immunity?
CORRECT ANSWER
breastfeeding
RATIONALE
Breastfeeding provides infants with antibodies from maternal serum, offering immediate protection against
pathogens without requiring the infant's immune system to produce its own antibodies. This exemplifies
naturally acquired passive immunity, where immunity is transferred from mother to child through biological
processes.
Q8 QUESTION 8 OF 254
bacteria that need oxygen to survive are called?
CORRECT ANSWER
aerobic
RATIONALE
Bacteria classified as aerobic require oxygen for cellular respiration and energy production, utilizing oxygen as
the terminal electron acceptor in their metabolic processes. This characteristic distinguishes them from
anaerobic bacteria, which thrive in environments devoid of oxygen.
Q9 QUESTION 9 OF 254
what is the molar mass of calcium if its atomic mass is 40 amu?
CORRECT ANSWER
40 grams/mole
Page 4
