SARAH MICHELLE LIVE REVIEW
NURSE PRACTITIONER EXAM PREP
1,000 ORIGINAL PRACTICE QUESTIONS & DETAILED
RATIONALES
2026–2027 STUDY GUIDE
✓ 1,000 practice questions
✓ A–D multiple-choice format
✓ Correct answers clearly identified
✓ Detailed rationales
✓ Major NP review domains
✓ Professional print-friendly PDF
Practice resource only: these are original questions, not actual or leaked exam questions, and no passing score is guaranteed.
, Practice Set 1 — Questions 1–25
1. [HEENT] Which finding is most characteristic of allergic rhinitis?
A. Clear rhinorrhea and sneezing
B. Hematuria
C. Diplopia
D. Claudication
Correct Answer: A. Clear rhinorrhea and sneezing
Rationale: Allergic rhinitis commonly causes sneezing, itching, congestion, and clear rhinorrhea.
2. [HEENT] Which lesion is classically associated with herpes zoster?
A. Grouped vesicles in a dermatomal distribution
B. Honey-colored crust only
C. Diffuse scaling
D. A flat macule only
Correct Answer: A. Grouped vesicles in a dermatomal distribution
Rationale: Herpes zoster typically produces painful grouped vesicles following a sensory dermatome.
3. [Endocrine] Which laboratory test is commonly used for initial screening of primary thyroid dysfunction?
A. TSH
B. Troponin
C. INR
D. Amylase
Correct Answer: A. TSH
Rationale: TSH is commonly used as an initial screening test for primary thyroid dysfunction.
4. [Endocrine] Which symptom is most consistent with hyperthyroidism?
A. Heat intolerance
B. Cold intolerance
C. Bradycardia
D. Constipation
Correct Answer: A. Heat intolerance
Rationale: Hyperthyroidism commonly causes heat intolerance, tremor, tachycardia, and weight loss.
5. [Endocrine] Which medication is commonly used as first-line therapy for type 2 diabetes when appropriate?
A. Metformin
B. Digoxin
C. Levothyroxine
D. Warfarin
Correct Answer: A. Metformin
Rationale: Metformin is a common first-line glucose-lowering medication when there are no contraindications.
,6. [Cardiovascular] Which symptom is most concerning for myocardial ischemia?
A. New pressure-like chest discomfort with exertion
B. Mild seasonal itching
C. Chronic callus
D. Brief hiccups
Correct Answer: A. New pressure-like chest discomfort with exertion
Rationale: Exertional pressure-like chest discomfort can indicate myocardial ischemia and requires appropriate evaluation.
7. [Cardiovascular] What defines a hypertensive emergency?
A. Severe blood pressure elevation with acute target-organ injury
B. Any single elevated reading
C. Mild elevation without symptoms
D. Low blood pressure
Correct Answer: A. Severe blood pressure elevation with acute target-organ injury
Rationale: A hypertensive emergency involves severe elevation accompanied by acute target-organ injury.
8. [Pulmonary] Which symptom is classic for asthma?
A. Episodic wheezing and variable airflow obstruction
B. Hematuria
C. Painless jaundice
D. Fixed joint deformity
Correct Answer: A. Episodic wheezing and variable airflow obstruction
Rationale: Asthma commonly causes episodic wheezing, cough, chest tightness, and variable airflow limitation.
9. [Pulmonary] Which finding is typical of pneumonia?
A. Fever, cough, and focal lung findings
B. Isolated hearing loss
C. Painless thyroid enlargement
D. Chronic nail changes
Correct Answer: A. Fever, cough, and focal lung findings
Rationale: Pneumonia often presents with fever, cough, dyspnea, and focal lung findings.
10. [GI] Which symptom is most suggestive of gastroesophageal reflux disease?
A. Heartburn after meals
B. Sudden unilateral weakness
C. Exertional calf pain
D. Hearing loss
Correct Answer: A. Heartburn after meals
Rationale: Heartburn and regurgitation are common symptoms of GERD.
11. [GI] Which abdominal finding is concerning for peritoneal irritation?
A. Rebound tenderness with guarding
B. Soft nontender abdomen
C. Normal appetite
D. Regular bowel movements
Correct Answer: A. Rebound tenderness with guarding
Rationale: Guarding and rebound tenderness can indicate peritoneal irritation.
, 12. [Infectious Disease] Which lesion is classically associated with Lyme disease?
A. Erythema migrans
B. Koplik spots
C. Dermatomal vesicles
D. Honey-colored crust
Correct Answer: A. Erythema migrans
Rationale: Erythema migrans is the characteristic expanding rash of early Lyme disease.
13. [Infectious Disease] Which medication is generally used to treat Rocky Mountain spotted fever?
A. Doxycycline
B. Fluconazole
C. Acyclovir
D. Amoxicillin only
Correct Answer: A. Doxycycline
Rationale: Doxycycline is the recommended treatment for suspected Rocky Mountain spotted fever in appropriate patients.
14. [Musculoskeletal] Which condition is an autoimmune inflammatory polyarthritis?
A. Rheumatoid arthritis
B. Osteoarthritis
C. Simple strain
D. Tendinitis
Correct Answer: A. Rheumatoid arthritis
Rationale: Rheumatoid arthritis is a systemic autoimmune inflammatory disease affecting synovial joints.
15. [Musculoskeletal] Which test is commonly used to assess the anterior cruciate ligament?
A. Lachman test
B. Weber test
C. Rinne test
D. Phalen test
Correct Answer: A. Lachman test
Rationale: The Lachman test is commonly used to assess ACL integrity.
16. [Women's Health] Which finding is concerning in a pregnant patient with severe headache and elevated blood pressure?
A. Possible preeclampsia
B. Normal pregnancy only
C. Allergic rhinitis
D. Otitis externa
Correct Answer: A. Possible preeclampsia
Rationale: Severe headache with hypertension during pregnancy can indicate preeclampsia and requires urgent evaluation.
17. [Women's Health] Which approach is used for cervical cancer screening?
A. Age- and risk-appropriate cytology and/or HPV testing
B. Urinalysis only
C. Chest radiograph
D. Serum sodium
Correct Answer: A. Age- and risk-appropriate cytology and/or HPV testing
Rationale: Cervical cancer screening uses age- and risk-appropriate cytology and/or HPV-based testing.
NURSE PRACTITIONER EXAM PREP
1,000 ORIGINAL PRACTICE QUESTIONS & DETAILED
RATIONALES
2026–2027 STUDY GUIDE
✓ 1,000 practice questions
✓ A–D multiple-choice format
✓ Correct answers clearly identified
✓ Detailed rationales
✓ Major NP review domains
✓ Professional print-friendly PDF
Practice resource only: these are original questions, not actual or leaked exam questions, and no passing score is guaranteed.
, Practice Set 1 — Questions 1–25
1. [HEENT] Which finding is most characteristic of allergic rhinitis?
A. Clear rhinorrhea and sneezing
B. Hematuria
C. Diplopia
D. Claudication
Correct Answer: A. Clear rhinorrhea and sneezing
Rationale: Allergic rhinitis commonly causes sneezing, itching, congestion, and clear rhinorrhea.
2. [HEENT] Which lesion is classically associated with herpes zoster?
A. Grouped vesicles in a dermatomal distribution
B. Honey-colored crust only
C. Diffuse scaling
D. A flat macule only
Correct Answer: A. Grouped vesicles in a dermatomal distribution
Rationale: Herpes zoster typically produces painful grouped vesicles following a sensory dermatome.
3. [Endocrine] Which laboratory test is commonly used for initial screening of primary thyroid dysfunction?
A. TSH
B. Troponin
C. INR
D. Amylase
Correct Answer: A. TSH
Rationale: TSH is commonly used as an initial screening test for primary thyroid dysfunction.
4. [Endocrine] Which symptom is most consistent with hyperthyroidism?
A. Heat intolerance
B. Cold intolerance
C. Bradycardia
D. Constipation
Correct Answer: A. Heat intolerance
Rationale: Hyperthyroidism commonly causes heat intolerance, tremor, tachycardia, and weight loss.
5. [Endocrine] Which medication is commonly used as first-line therapy for type 2 diabetes when appropriate?
A. Metformin
B. Digoxin
C. Levothyroxine
D. Warfarin
Correct Answer: A. Metformin
Rationale: Metformin is a common first-line glucose-lowering medication when there are no contraindications.
,6. [Cardiovascular] Which symptom is most concerning for myocardial ischemia?
A. New pressure-like chest discomfort with exertion
B. Mild seasonal itching
C. Chronic callus
D. Brief hiccups
Correct Answer: A. New pressure-like chest discomfort with exertion
Rationale: Exertional pressure-like chest discomfort can indicate myocardial ischemia and requires appropriate evaluation.
7. [Cardiovascular] What defines a hypertensive emergency?
A. Severe blood pressure elevation with acute target-organ injury
B. Any single elevated reading
C. Mild elevation without symptoms
D. Low blood pressure
Correct Answer: A. Severe blood pressure elevation with acute target-organ injury
Rationale: A hypertensive emergency involves severe elevation accompanied by acute target-organ injury.
8. [Pulmonary] Which symptom is classic for asthma?
A. Episodic wheezing and variable airflow obstruction
B. Hematuria
C. Painless jaundice
D. Fixed joint deformity
Correct Answer: A. Episodic wheezing and variable airflow obstruction
Rationale: Asthma commonly causes episodic wheezing, cough, chest tightness, and variable airflow limitation.
9. [Pulmonary] Which finding is typical of pneumonia?
A. Fever, cough, and focal lung findings
B. Isolated hearing loss
C. Painless thyroid enlargement
D. Chronic nail changes
Correct Answer: A. Fever, cough, and focal lung findings
Rationale: Pneumonia often presents with fever, cough, dyspnea, and focal lung findings.
10. [GI] Which symptom is most suggestive of gastroesophageal reflux disease?
A. Heartburn after meals
B. Sudden unilateral weakness
C. Exertional calf pain
D. Hearing loss
Correct Answer: A. Heartburn after meals
Rationale: Heartburn and regurgitation are common symptoms of GERD.
11. [GI] Which abdominal finding is concerning for peritoneal irritation?
A. Rebound tenderness with guarding
B. Soft nontender abdomen
C. Normal appetite
D. Regular bowel movements
Correct Answer: A. Rebound tenderness with guarding
Rationale: Guarding and rebound tenderness can indicate peritoneal irritation.
, 12. [Infectious Disease] Which lesion is classically associated with Lyme disease?
A. Erythema migrans
B. Koplik spots
C. Dermatomal vesicles
D. Honey-colored crust
Correct Answer: A. Erythema migrans
Rationale: Erythema migrans is the characteristic expanding rash of early Lyme disease.
13. [Infectious Disease] Which medication is generally used to treat Rocky Mountain spotted fever?
A. Doxycycline
B. Fluconazole
C. Acyclovir
D. Amoxicillin only
Correct Answer: A. Doxycycline
Rationale: Doxycycline is the recommended treatment for suspected Rocky Mountain spotted fever in appropriate patients.
14. [Musculoskeletal] Which condition is an autoimmune inflammatory polyarthritis?
A. Rheumatoid arthritis
B. Osteoarthritis
C. Simple strain
D. Tendinitis
Correct Answer: A. Rheumatoid arthritis
Rationale: Rheumatoid arthritis is a systemic autoimmune inflammatory disease affecting synovial joints.
15. [Musculoskeletal] Which test is commonly used to assess the anterior cruciate ligament?
A. Lachman test
B. Weber test
C. Rinne test
D. Phalen test
Correct Answer: A. Lachman test
Rationale: The Lachman test is commonly used to assess ACL integrity.
16. [Women's Health] Which finding is concerning in a pregnant patient with severe headache and elevated blood pressure?
A. Possible preeclampsia
B. Normal pregnancy only
C. Allergic rhinitis
D. Otitis externa
Correct Answer: A. Possible preeclampsia
Rationale: Severe headache with hypertension during pregnancy can indicate preeclampsia and requires urgent evaluation.
17. [Women's Health] Which approach is used for cervical cancer screening?
A. Age- and risk-appropriate cytology and/or HPV testing
B. Urinalysis only
C. Chest radiograph
D. Serum sodium
Correct Answer: A. Age- and risk-appropriate cytology and/or HPV testing
Rationale: Cervical cancer screening uses age- and risk-appropriate cytology and/or HPV-based testing.
