QUESTIONS AND CORRECT DETAILED ANSWERS ALREADY A
GRADED WITH EXPERT FEEDBACK |CURRENTLY TESTING |NEW AND
REVISED
300 Questions • Answers • Brief Clinical Rationales
2026 PRACTICE EDITION
FORMAT
Four-option multiple choice
Correct answer highlighted
Clinical rationale after each question
ATI RN Pharmacology • 300 Original Practice Questions • 2026 Page 1
, QUESTIONS 1–25
1. A client is receiving total parenteral nutrition (TPN). Which nursing action is appropriate?
A. Use the TPN line for all medications
B. Stop glucose monitoring
C. Monitor the client's weight regularly
D. Leave the solution unrefrigerated for days
ANSWER — C. Monitor the client's weight regularly
Rationale: Weight trends help evaluate nutrition and fluid status.
2. A nurse is preparing to administer a medication. Which action best verifies the correct client?
A. Ask the roommate to confirm the name
B. Identify the client by diagnosis only
C. Use two client identifiers
D. Use the room number
ANSWER — C. Use two client identifiers
Rationale: Two identifiers such as name and date of birth reduce wrong-client medication errors.
3. A nurse is mixing regular insulin with NPH insulin. Which action is correct?
A. Draw regular insulin before NPH insulin
B. Mix insulin glargine with NPH
C. Shake regular insulin vigorously
D. Draw NPH first
ANSWER — A. Draw regular insulin before NPH insulin
Rationale: Clear before cloudy prevents contaminating regular insulin with NPH.
ATI RN Pharmacology • 300 Original Practice Questions • 2026 Page 2
, 4. Which medication should be withheld when a client prescribed nitroglycerin reports recent sildenafil use?
A. Acetaminophen
B. Nitroglycerin
C. Ferrous sulfate
D. Famotidine
ANSWER — B. Nitroglycerin
Rationale: Nitrates and PDE-5 inhibitors can cause profound hypotension when combined.
5. A client receiving morphine by PCA is difficult to arouse and has a respiratory rate of 8/min. What is the
priority?
A. Give another opioid
B. Stop opioid administration as appropriate and support breathing/notify the provider per protocol
C. Offer a sedative
D. Encourage more PCA doses
ANSWER — B. Stop opioid administration as appropriate and support breathing/notify the provider per protocol
Rationale: Respiratory depression is a life-threatening opioid adverse effect.
6. Which medication should the nurse anticipate for opioid-induced respiratory depression?
A. Naloxone
B. Vitamin K
C. Protamine
D. Flumazenil
ANSWER — A. Naloxone
Rationale: Naloxone is an opioid antagonist.
ATI RN Pharmacology • 300 Original Practice Questions • 2026 Page 3
, 7. A client weighs 132 lb and receives 5 mg/kg/day in 4 equal doses. How much per dose?
A. 75 mg
B. 150 mg
C. 25 mg
D. 50 mg
ANSWER — A. 75 mg
Rationale: 132 lb ÷ 2.2 = 60 kg; 5 × 60 = 300 mg/day; 300 ÷ 4 = 75 mg.
8. A client receiving penicillin develops urticaria and wheezing. What is the priority?
A. Stop the medication and initiate emergency treatment for an allergic reaction
B. Document it as expected
C. Give the next dose
D. Encourage ambulation
ANSWER — A. Stop the medication and initiate emergency treatment for an allergic reaction
Rationale: Urticaria and wheezing can indicate anaphylaxis.
9. Which teaching is appropriate for a client taking metronidazole?
A. Drink alcohol with each dose
B. Avoid alcohol during treatment and for the recommended period afterward
C. Double a missed dose
D. Stop all fluids
ANSWER — B. Avoid alcohol during treatment and for the recommended period afterward
Rationale: Alcohol can cause a disulfiram-like reaction with metronidazole.
ATI RN Pharmacology • 300 Original Practice Questions • 2026 Page 4