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NGR 6172 Pharm EXAM 1 Questions with 100% Verified Answers Latest Update

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NGR 6172 Pharm EXAM 1 Questions with 100% Verified Answers Latest Update

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NGR 6172 Pharm EXAM 1 Questions with 100% Verified
Answers Latest Update
Question: Aspirin- MOA

Answer:

Binds irreversibly to cyclooxyrgenase-1 and 2 (COX 1 and 2)
Decrease prostaglandin and thromboxane A2 production

Question: Plavix (clopidogrel) -MOA

Answer:

Produg- irreversibly inhibits P2Y12 ADP-mediated platelet activation and aggregation

Question: Boxed warning of Plavix

Answer:

conversion to active metabolite require (CYP 450 2C19) Poor metabolizers - higher CV
events

Question: Plavix- avoid to take with what

Answer:

2c19 inhibitors (omeprazole, esomeprazole) increased bleed

Question: post CABG how long for antiplatelet therapy?

Answer:

1 year

Question: Post bare metal stent placement: how long for antiplatelet therapy?

Answer:

1 month or less

Question: Drug - eluting stent placement: how long for anti platelet therapy?

Answer:

6 months or less

Question: P2Y12 inhibitors MOA

Answer:

Binds the adenosine diphosphate (ADP) P2Y12 receptor on the platelet surface Prevents
activation of the GPIIb/IIIa receptor complex Reduces platelet aggregation

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