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Exams Includes Frequently Tested Questions With
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1. Hypothyroidism - Correct Answer: hashimoto's
insufficient thyroid hormones (T3 + T4)
primary hypothyroid - elevated TSH, low T4, low T3
subclinical hypothyroid - elevated TSH, normal T4 & T3
congenital hypothyroidism - present at birth
Causes - can be caused by meds like amiodarone or lithium, by iodine deficiency,
iatrogenic (thyroidectomy or radioactive iodine)
S/S -- Think "everything slows down"
Fatigue, weight gain
Cold intolerance
Constipation
Depression
Dry skin, hair loss
Bradycardia
Menstrual irregularities
Dry, coarse skin
,Periorbital edema
S/S in babies: lethargy, poor feeding, hypotonia, jaundice, hoarse cry,
macroglossia, coarse face hairs, constipation, umbilical hernia
2. Hypothyroid treatment - Correct Answer: Levothyroxine - healthy adults
<60 - 1.6mcg/kg/day
Elderly/Comorbidities - 12.5-25mcg/kg/day
TSH determines levothyroxine dosage
subclinical - treat if TSH >10
Adjust dose q4-6 weeks, once stable every 6-12 months
Pregnancy - increase levothyroxine dose by 30%
Synthroid - synthetic treatment containing T4
Armour Thyroid (Desiccated) - unpredictable, derived from pig, less stable,
contains T3+T4
Take first thing in the morning on an empty stomach
Avoid taking with calcium or iron supplements
3. Myxedema Coma - Correct Answer: Emergency!
Severe hypothyroidism
AMS, hypothermia, bradycardia
, 4. Hyperthyroidism - Correct Answer: excess T3 and T4
Primary hyperthyroid - low TSH, elevated T3/T4
S/S: goiter, exophthalmos, pretibial myxedema, heat intolerance, weight loss,
tremors, tachycardia, palpitations, tachycardia, fatigue, tremor, depression, light
periods, hyperreflexia, insomnia, anxiety
clonus: abnormal reflex movements of the foot by sudden dorsiflexion causing
contraction and relaxation
5. Hyperthyroidism Treatment - Correct Answer: 1st line: methimazole -
inhibits thyroid hormone synthesis
Pregnancy - use PTU in first trimester
Other options:
- Beta blocker to manage tachycardia
- Radioactive iodine - treatment of graves
- Surgery to remove goiter, nodules, malignancy
6. Addison's Disease - Correct Answer: Primary Adrenal Insufficiency -
damage to the adrenal gland decreases cortisol and aldosterone
Primary - caused by autoimmune, TB, HIV, CMV, fungal, tumors, congenital
adrenal hyperplasia, hemorrhage
, Secondary - caused by pituitary dysfunction leading to decreased ACH and adrenal
atrophy, can be from chronic steroid use with abrupt withdrawal
S/S: fatigue, weight loss, hypotension, salt craving, hyperpigmentation
7. Addisonian Crisis - Correct Answer: life threatening cortisol deficiency
triggered by stress, illness, steroid withdrawal
s/s: hypotension, shock, hyponatremia, hyperkalemia
Tx: IV hydrocortisone, fluids, correct electrolytes, give glucose
8. Cushing's Syndrome - Correct Answer: chronic cortisol excess
Tx: gradual taper of steroids
9. Cushing's Disease - Correct Answer: pituitary adenoma causing
increased ACTH leading to increased cortisol
s/s: moon face, buffalo hump, central obesity, HTN, hyperglycemia, muscle
weakness, purple striae, skin thinning, easy bruising, poor wound healing
Untreated can cause osteoporosis, infections, severe hypertension
Dx: