Epinephrine vial concentration used for anaphylaxis 1:1000 (1mg/ml)
How many mcg/ml if you put 1ml of 1:1000 epinephrine in a 100 ml bag? 10 mcg/ml
How many mcg/ml if you put 1ml of 1:1000 epinephrine in a 250 ml bag? 4 mcg/ml
Adult dosing (epinephrine IV) for anaphylaxis for mild to moderate hypotension 10 to 50 mcg increments and repeat as needed
Adult dosing (epinephrine IV) for anaphylaxis for cardiovascular collapse or cardiac arrest 0.5 to 1 mg boluses and repeat as needed. Consider epinephrine infusion to maintain BP.
Epinephrine infusion dose range 1-16 mcg/min
Vasopressin IV dose for anaphylaxys and why would you give this drug 10 to 40 units for patients refractory to epinephrine. Initial dose is 1-2 units as needed
Glucagon IV dose for anaphylaxis and why would you give this 1 to 5 mg if the patient received beta-blockers
Methylene blue IV dose for anaphylaxis and why would you give this drug 10 - 50 mg when the patient is refractory to epinephrine or vasopressin
How much albuterol to give in presence of bronchospasm due to anaphylaxis? >10 putts or 2.5 mg albuterol per aerosol device via ETT/inspiratory limb
Diphenhydramine IV dose (Benadryl) what class of drug and dose for anaphylaxis? H1 blocker. 50 mg
Famotidine IV dose (Pepcid) what class of drug and dose for anaphylaxis? H2 blocker. 20 mg
Dexamethasone IV dose for anaphylaxis 20 mg bolus
Methylprednilosone IV dose for anaphylaxis 100 mg bolus
Hydrocortisone IV dose for anaphylaxis 100 - 200 mg bolus
Draw a mast cell tryptase level within 2 hours. Check mast cell serum tryptase level (requires
What special test should I order if anaphylaxis occurs? special handling, consult lab personnel). Repeat Q4h and at 18-24 hours post reaction. 11.5
ng/ml is high
Pediatric doses of epinephrine: early phase without profound hypotension, shock, or cardiac
Epinephrine IM 10 mcg/kg in lateral thigh Q5-15 minutes. Max 300 mcg per dose
arrest or without IV/IO
Pediatric epinephrine IV dose for anaphylaxis 1-10 mcg/kg as needed
Pediatric epinephrine IV dose for anaphylaxis with profound hypotension or shock 0.5 to 1 mcg/kg and increase rapidly to 10 mcg/kg as needed (max 1000 mcg)
Pediatric epinephrine infusion for anaphylaxis 0.02 to 0.2 mcg/kg/min
Pediatric epinephrine IV dose for cardiac collapse or arrest 10 mck/kg and repeat every 3-5 minutes
Expanding circulating volume in anaphylaxis for pediatric patients 10-30 ml/kg
Drug and dose for bronchospasm during anaphylaxis in the pediatric population MDI or aerosol of beta agonist like albuterol (Proventil) 4-10 putts as needed
Diphenhydramine IV pediatric dose for anaphylaxis 1 mg/kg up to 50mg
Famotidine IV pediatric dose for anaphylaxis 0.25 mg/kg
Methylprednilosone IV pediatric dosing for anaphylaxis 1 to 2 mg/kg
Dexamethasone IV pediatric dosing for anaphylaxis 0.2 mg/kg
Notify surgeon, call for help, ask for the crash cart
Secure airway and increase FiO2 to 100%
Remove ottending agent
Treat hypotension (Trendelenburg, epinephrine (bolus or infusion if necessary), vasopressin,
Levophed, glucagon, methylene blue, increase circulating volume, insert more IVs)
List the interventions of anaphylaxis Insert Foley
Albuterol if bronchospasm (also increase Sevo if BP permits)
H1 and H2 blockers (Benadryl and Pepcid)
Steroids (Decadron, methylprednilosone, or hydrocortisone)
Aline if continuous infusion of vasopressors
TEE
1/2
How many mcg/ml if you put 1ml of 1:1000 epinephrine in a 100 ml bag? 10 mcg/ml
How many mcg/ml if you put 1ml of 1:1000 epinephrine in a 250 ml bag? 4 mcg/ml
Adult dosing (epinephrine IV) for anaphylaxis for mild to moderate hypotension 10 to 50 mcg increments and repeat as needed
Adult dosing (epinephrine IV) for anaphylaxis for cardiovascular collapse or cardiac arrest 0.5 to 1 mg boluses and repeat as needed. Consider epinephrine infusion to maintain BP.
Epinephrine infusion dose range 1-16 mcg/min
Vasopressin IV dose for anaphylaxys and why would you give this drug 10 to 40 units for patients refractory to epinephrine. Initial dose is 1-2 units as needed
Glucagon IV dose for anaphylaxis and why would you give this 1 to 5 mg if the patient received beta-blockers
Methylene blue IV dose for anaphylaxis and why would you give this drug 10 - 50 mg when the patient is refractory to epinephrine or vasopressin
How much albuterol to give in presence of bronchospasm due to anaphylaxis? >10 putts or 2.5 mg albuterol per aerosol device via ETT/inspiratory limb
Diphenhydramine IV dose (Benadryl) what class of drug and dose for anaphylaxis? H1 blocker. 50 mg
Famotidine IV dose (Pepcid) what class of drug and dose for anaphylaxis? H2 blocker. 20 mg
Dexamethasone IV dose for anaphylaxis 20 mg bolus
Methylprednilosone IV dose for anaphylaxis 100 mg bolus
Hydrocortisone IV dose for anaphylaxis 100 - 200 mg bolus
Draw a mast cell tryptase level within 2 hours. Check mast cell serum tryptase level (requires
What special test should I order if anaphylaxis occurs? special handling, consult lab personnel). Repeat Q4h and at 18-24 hours post reaction. 11.5
ng/ml is high
Pediatric doses of epinephrine: early phase without profound hypotension, shock, or cardiac
Epinephrine IM 10 mcg/kg in lateral thigh Q5-15 minutes. Max 300 mcg per dose
arrest or without IV/IO
Pediatric epinephrine IV dose for anaphylaxis 1-10 mcg/kg as needed
Pediatric epinephrine IV dose for anaphylaxis with profound hypotension or shock 0.5 to 1 mcg/kg and increase rapidly to 10 mcg/kg as needed (max 1000 mcg)
Pediatric epinephrine infusion for anaphylaxis 0.02 to 0.2 mcg/kg/min
Pediatric epinephrine IV dose for cardiac collapse or arrest 10 mck/kg and repeat every 3-5 minutes
Expanding circulating volume in anaphylaxis for pediatric patients 10-30 ml/kg
Drug and dose for bronchospasm during anaphylaxis in the pediatric population MDI or aerosol of beta agonist like albuterol (Proventil) 4-10 putts as needed
Diphenhydramine IV pediatric dose for anaphylaxis 1 mg/kg up to 50mg
Famotidine IV pediatric dose for anaphylaxis 0.25 mg/kg
Methylprednilosone IV pediatric dosing for anaphylaxis 1 to 2 mg/kg
Dexamethasone IV pediatric dosing for anaphylaxis 0.2 mg/kg
Notify surgeon, call for help, ask for the crash cart
Secure airway and increase FiO2 to 100%
Remove ottending agent
Treat hypotension (Trendelenburg, epinephrine (bolus or infusion if necessary), vasopressin,
Levophed, glucagon, methylene blue, increase circulating volume, insert more IVs)
List the interventions of anaphylaxis Insert Foley
Albuterol if bronchospasm (also increase Sevo if BP permits)
H1 and H2 blockers (Benadryl and Pepcid)
Steroids (Decadron, methylprednilosone, or hydrocortisone)
Aline if continuous infusion of vasopressors
TEE
1/2
