ANCC AGPCNP Study Set
Age associated exchange to pharmacokinetics - ANS-- Increase in fats-to-water ratio
- Decrease in albumin and plasma proteins
- Decrease in liver blood waft and length
- Decrease in some CYP450 enzyme pathways (reduced drug clearance)
- Decrease in glomerular filtration rate (GFR)
Alpha-Blockers - ANS-- Relaxes easy muscular tissues at the bladder neck and prostate,
improves signs of BPH
- "-osin" - terazosin and doxazosin (handiest ones that tx BP and BPH)
-ASE: Orthostatic hypotension, dizziness
-Potent vasodilators, provide at bedtime at very low dose and slowly titrate up (Careful with
elderly due to fall chance)
- Only 1st line for men with BPH and HTN
Angiotensin Receptor Blockers (ARBs) - ANS-Use: HTN, DM (renal safety), submit-MI, and HF
or left ventricular HF)
-ARBs block angiotensin II (less aldosterone)
-"sartan" (losartan, valsartan, irbesartan and so forth.)
- DO NOT use at some point of pregnancy
-AEs: Hypotension, hyperkalemia, angioedema, AKI
zero excreted in breast milk
Angiotensin-converting enzyme (ACE) inhibitors - ANS--Use: HTN, DM (renal safety), CKD,
post-MI, and HF or left ventricular HF
- "pril" (ramipril, lisinopril, beanzepril, enapril etc.)
- Block conversion of angiotensin I to angiotensin II (effective vasoconstrictor)
-- desired dealers for patients with HFrEF are ACEIs or ARBs and mineralcorticoids receptor
antagonists
-BB warning: Can reason death/injury to growing fetus
-Common aspect effect: Dry cough (prevent ACEI and transfer to some other magnificence)
-Contraindicated in pregnancy, renal artery stenosis, angioedema, hyperkalemia(>five.5)
- Protect the kidneys so preferred in diabetics or pts with moderate-to moderate CKD
- 1st line therapy for HF with left ventricular dysfxn or HFrEF
-Excreted in breast milk
Area underneath the curve (AUC) - ANS-the common quantity of a drug inside the blood after a
dose is given. It is a degree of the availability (bioavailability) of a drug after it is administered.
Aspirin - ANS-- age 50-fifty nine, same or more than 10% CVD hazard
, Bactericidal - ANS-antibiotics kill bacteria
Bacteriostatic - ANS-inhibits bacterial increase so immune device can clean contamination
BEERS Criteria - ANS-Medications to keep away from in sixty five+
-1st gen antihistamines (diphenhydramine, doxylamine, chlorpheniramine) keep away from due
to the fact dizziness and falls
- Recent recommendations:
--Antipsychotics: Quetiapine, clozapine, and pimavanserin can be used with warning.
-- Rivaroxaban and dabigatran: Higher bleeding chance than warfarin and different direct oral
anticoagulants
--Tramadol: Risk of hyponatremia from syndrome of beside the point antidiuretic hormone
secretion
--Opioids: Do not integrate with benzodiazepines or gabapentinoids as they growth the risk of
severe respiratory depression
Beta Blocker Contraindications - ANS-- Chronic lung disease (COPD, bronchial asthma,
emphysema, persistent bronchitis)
-Do no longer discontinue BB all at once -- can purpose extreme rebound (hypertensive crisis)
Beta Blockers - ANS-- Use: HTN, put up-MI, angina, arrhythmias, and migraine prophylaxis
-Cardioselective BB are stronger (b/c block beta 1 receptors observed in particular in coronary
heart) -- atenolol, metoprolol
- Noncardioselective BB: propranolol and carvedilol
- Contraindications: asthma, COPD, chronic bronchitis, emphysema, bradycardia, AV block
- ASE: Bronchospasm, bradycardia, Depression, fatigue, erectile dysfxn, blunts hypoglycemic
reaction, HF
breast cancer threat factors - ANS--Age over 50
- Previous history of breast cancer
-BRCA1 or BRCA2 gene mutation
-Hx of excessive-dose radiation therapy to the chest at a young age
-2 or more 1st degree loved ones with breast cancer
-Early menarche, overdue menopause, nulliparity (longer exposure to estrogen)
-Obesity
Calcium Channel Blockers - ANS-- Use: HTN, angina pectoris, coronary artery spasms,
supraventricular dysrhythmias, pulmonary high blood pressure, hypertrophic cardiomyopathy,
and Raynaud's phenomenon (1st line)
-"ipine" (amlodipine, nifedipine, felodipine, nicardipine, isradipine)
-
Cephalosporins - ANS-- Beta-lactam own family
Age associated exchange to pharmacokinetics - ANS-- Increase in fats-to-water ratio
- Decrease in albumin and plasma proteins
- Decrease in liver blood waft and length
- Decrease in some CYP450 enzyme pathways (reduced drug clearance)
- Decrease in glomerular filtration rate (GFR)
Alpha-Blockers - ANS-- Relaxes easy muscular tissues at the bladder neck and prostate,
improves signs of BPH
- "-osin" - terazosin and doxazosin (handiest ones that tx BP and BPH)
-ASE: Orthostatic hypotension, dizziness
-Potent vasodilators, provide at bedtime at very low dose and slowly titrate up (Careful with
elderly due to fall chance)
- Only 1st line for men with BPH and HTN
Angiotensin Receptor Blockers (ARBs) - ANS-Use: HTN, DM (renal safety), submit-MI, and HF
or left ventricular HF)
-ARBs block angiotensin II (less aldosterone)
-"sartan" (losartan, valsartan, irbesartan and so forth.)
- DO NOT use at some point of pregnancy
-AEs: Hypotension, hyperkalemia, angioedema, AKI
zero excreted in breast milk
Angiotensin-converting enzyme (ACE) inhibitors - ANS--Use: HTN, DM (renal safety), CKD,
post-MI, and HF or left ventricular HF
- "pril" (ramipril, lisinopril, beanzepril, enapril etc.)
- Block conversion of angiotensin I to angiotensin II (effective vasoconstrictor)
-- desired dealers for patients with HFrEF are ACEIs or ARBs and mineralcorticoids receptor
antagonists
-BB warning: Can reason death/injury to growing fetus
-Common aspect effect: Dry cough (prevent ACEI and transfer to some other magnificence)
-Contraindicated in pregnancy, renal artery stenosis, angioedema, hyperkalemia(>five.5)
- Protect the kidneys so preferred in diabetics or pts with moderate-to moderate CKD
- 1st line therapy for HF with left ventricular dysfxn or HFrEF
-Excreted in breast milk
Area underneath the curve (AUC) - ANS-the common quantity of a drug inside the blood after a
dose is given. It is a degree of the availability (bioavailability) of a drug after it is administered.
Aspirin - ANS-- age 50-fifty nine, same or more than 10% CVD hazard
, Bactericidal - ANS-antibiotics kill bacteria
Bacteriostatic - ANS-inhibits bacterial increase so immune device can clean contamination
BEERS Criteria - ANS-Medications to keep away from in sixty five+
-1st gen antihistamines (diphenhydramine, doxylamine, chlorpheniramine) keep away from due
to the fact dizziness and falls
- Recent recommendations:
--Antipsychotics: Quetiapine, clozapine, and pimavanserin can be used with warning.
-- Rivaroxaban and dabigatran: Higher bleeding chance than warfarin and different direct oral
anticoagulants
--Tramadol: Risk of hyponatremia from syndrome of beside the point antidiuretic hormone
secretion
--Opioids: Do not integrate with benzodiazepines or gabapentinoids as they growth the risk of
severe respiratory depression
Beta Blocker Contraindications - ANS-- Chronic lung disease (COPD, bronchial asthma,
emphysema, persistent bronchitis)
-Do no longer discontinue BB all at once -- can purpose extreme rebound (hypertensive crisis)
Beta Blockers - ANS-- Use: HTN, put up-MI, angina, arrhythmias, and migraine prophylaxis
-Cardioselective BB are stronger (b/c block beta 1 receptors observed in particular in coronary
heart) -- atenolol, metoprolol
- Noncardioselective BB: propranolol and carvedilol
- Contraindications: asthma, COPD, chronic bronchitis, emphysema, bradycardia, AV block
- ASE: Bronchospasm, bradycardia, Depression, fatigue, erectile dysfxn, blunts hypoglycemic
reaction, HF
breast cancer threat factors - ANS--Age over 50
- Previous history of breast cancer
-BRCA1 or BRCA2 gene mutation
-Hx of excessive-dose radiation therapy to the chest at a young age
-2 or more 1st degree loved ones with breast cancer
-Early menarche, overdue menopause, nulliparity (longer exposure to estrogen)
-Obesity
Calcium Channel Blockers - ANS-- Use: HTN, angina pectoris, coronary artery spasms,
supraventricular dysrhythmias, pulmonary high blood pressure, hypertrophic cardiomyopathy,
and Raynaud's phenomenon (1st line)
-"ipine" (amlodipine, nifedipine, felodipine, nicardipine, isradipine)
-
Cephalosporins - ANS-- Beta-lactam own family
