2026–2027) |Comprehensive Nursing Questions with
Detailed Answers & Rationales | PDF
Overview
Prepare for the WGU D455 Exit HESI HCV2 with this comprehensive 150-question
practice exam designed to strengthen clinical judgment, critical thinking, and NCLEX-style
decision-making. This practice exam reflects the difficulty and format commonly
encountered on nursing exit assessments, covering adult health, pharmacology, pediatrics,
maternal-newborn, mental health, leadership, emergency nursing, and evidence-based
practice. Every question includes the correct answer in bold and a detailed rationale to
reinforce understanding.
Coverage
Original HESI Exit HCV2–Style Practice Questions
Detailed Answers and Rationales
NGN (Next Generation NCLEX)-Style Clinical Judgment
Adult Medical-Surgical Nursing
Cardiovascular Disorders
Respiratory Disorders
Endocrine Disorders
Diabetes Mellitus
Renal and Genitourinary Disorders
Gastrointestinal Disorders
Hepatic Disorders
Neurological Disorders
, Musculoskeletal Disorders
Oncology Nursing
Hematology
Fluid and Electrolyte Disorders
Acid–Base Balance
Pharmacology and Medication Safety
Dosage Calculation Concepts
Intravenous Therapy
Infection Prevention and Control
Isolation Precautions
Emergency and Critical Care
Shock and Sepsis
Trauma Nursing
Maternal-Newborn Nursing
Obstetric Emergencies
Pediatric Nursing
Growth and Development
Immunizations
Mental Health Nursing
Psychiatric Disorders
Therapeutic Communication
Community and Public Health Nursing
Gerontological Nursing
Leadership and Management
Delegation and Prioritization
Ethical and Legal Nursing Practice
Patient Safety and Quality Improvement
, Evidence-Based Nursing Practice
NCLEX®/HESI Clinical Decision-Making
Exam Format: Each question includes four answer choices (A–D), the correct answer
highlighted in bold, and an evidence-based rationale.
Instructions: Choose the one best answer for each question. Each question includes the
correct answer in bold and an evidence-based rationale. These questions are original and
modeled after the style and difficulty of HESI Exit and NCLEX-style exams.
Question 1
A nurse is caring for a 68-year-old client admitted with acute decompensated heart failure
who reports increasing shortness of breath, orthopnea, and bilateral lower-extremity edema.
Which nursing intervention should take priority?
A. Encourage increased oral fluid intake.
B. Place the client in the Trendelenburg position.
C. Position the client in high-Fowler's position and administer oxygen as prescribed.
D. Encourage the client to ambulate in the hallway.
Answer: C
Rationale: The priority is improving oxygenation and reducing preload. High-Fowler's
position decreases venous return and improves lung expansion while supplemental oxygen
helps correct hypoxemia.
, Question 2
A client with type 1 diabetes mellitus becomes confused, diaphoretic, and tremulous before
lunch. Which nursing action is most appropriate?
A. Administer the scheduled insulin dose.
B. Obtain a urine ketone specimen.
C. Encourage the client to rest.
D. Check the blood glucose level immediately and administer a rapid-acting
carbohydrate if hypoglycemia is confirmed.
Answer: D
Rationale: The symptoms suggest hypoglycemia. Immediate assessment and treatment are
essential to prevent progression to seizures or loss of consciousness.
Question 3
A postoperative client suddenly develops dyspnea, tachycardia, pleuritic chest pain, and
oxygen saturation of 86% on room air. Which complication should the nurse suspect first?
A. Atelectasis
B. Pneumonia
C. Myocardial infarction