RELIAS RN PHARMACOLOGY A
PROPHECY RN PHARMACOLOGY EXAM PRACTICE
2026/2027 EDITION
This is an independent practice exam for educational study; it is not an official ATI Testing proctored assessment.
Section Overview
This comprehensive online practice exam contains 110 questions across seven sections, aligned with the
Relias/Prophecy RN Pharmacology A competency blueprint, the current NCLEX-RN pharmacology standards, and
evidence-based medication administration practices for 2026/2027.
Sec Topic Qs
1 Medication Administration & Dosage Calculations - Oral, IV, Weight-Based 20
2 Cardiovascular & Anticoagulant Medications - Digoxin, Heparin, Warfarin 20
3 Antibiotics & Anti-infectives - Penicillins, Cephalosporins, Vancomycin 15
4 Endocrine & Metabolic Medications - Insulin, Glucocorticoids, Thyroid 15
5 Diuretics & Electrolyte Management - HCTZ, Spironolactone, Furosemide 10
6 Medication Safety & Adverse Effects - Interactions, Toxicity 15
7 Integrated Clinical Scenarios - Complex Patient Cases 15
TOTAL 110
Instructions
For each question, select the single best answer. Use the answer key at the end of the exam to check your work. Each
item includes a brief rationale explaining the correct response.
Answer Key Distribution: 28 A · 28 B · 27 C · 27 D
, Section 1: Medication Administration & Dosage Calculations - Oral, IV, and
Weight-Based Dosing
Q1: The 'Six Rights' of medication administration include which of the following?
A. Right client, room, bed, chair, door, and window
B. Right client, drug, dose, route, time, and documentation [CORRECT]
C. Right color, size, shape, taste, and smell
D. Right family, doctor, nurse, and pharmacist
Correct Answer: B
Rationale: The Six Rights include client, drug, dose, route, time, and documentation. The other options are incorrect.
Q2: A client is prescribed 500 mg of a medication, and the available tablet is 250 mg. How many tablets should be
given?
A. 1 tablet
B. 0.5 tablet
C. 4 tablets
D. 2 tablets [CORRECT]
Correct Answer: D
Rationale: 500 ÷ 250 = 2 tablets. The other options misapply the ratio.
Q3: A medication is ordered at 20 mg/kg for a client weighing 70 kg. The total dose is:
A. 1,400 mg [CORRECT]
B. 700 mg
C. 2,000 mg
D. 90 mg
Correct Answer: A
Rationale: 20 mg/kg × 70 kg = 1,400 mg. The other options misapply the calculation.
Q4: A client is prescribed 1,000 mL of IV fluid over 8 hours. The hourly rate is:
A. 100 mL/hour
B. 250 mL/hour
C. 125 mL/hour [CORRECT]
D. 1,000 mL/hour
Correct Answer: C
Rationale: 1,000 ÷ 8 = 125 mL/hour. The other options misapply the calculation.
Q5: An IV medication is ordered at 500 mg in 250 mL to infuse over 2 hours. The rate in mL/hour is:
A. 250 mL/hour
B. 50 mL/hour
C. 125 mL/hour [CORRECT]
D. 500 mL/hour
Correct Answer: C
Rationale: 250 mL ÷ 2 hours = 125 mL/hour. The other options misapply the calculation.
Q6: A client is prescribed 1500 mg of a medication that is available as 500 mg tablets. How many tablets?
A. 2 tablets
B. 5 tablets
C. 3 tablets [CORRECT]
D. 1 tablet
Correct Answer: C
Rationale: 1500 ÷ 500 = 3 tablets. The other options misapply the ratio.
Q7: Weight-based dosing is most commonly calculated using the client's:
A. Height
B. Age
Relias RN Pharmacology A - 2026/2027 Page 2
, C. Blood pressure
D. Weight in kilograms [CORRECT]
Correct Answer: D
Rationale: Weight-based dosing uses the client's weight in kilograms. The other factors are not the basis.
Q8: A medication is ordered at 5 mg/kg/day divided into two doses for a 60 kg client. Each dose is:
A. 150 mg [CORRECT]
B. 300 mg
C. 75 mg
D. 30 mg
Correct Answer: A
Rationale: Total daily = 5 × 60 = 300 mg; divided by 2 = 150 mg per dose. The other options are incorrect.
Q9: Which of the following is the correct abbreviation to avoid when documenting medication doses?
A. mg
B. mL
C. PO
D. 'U' for units (write 'units') [CORRECT]
Correct Answer: D
Rationale: 'U' is on the do-not-use list because it can be misread. mg, mL, and PO are acceptable when written correctly.
Q10: When calculating an IV infusion rate, the nurse uses:
A. The client's height
B. The room temperature
C. The client's age
D. The volume to be infused and the time over which it infuses [CORRECT]
Correct Answer: D
Rationale: IV rate is calculated from volume and time. The other factors are not used.
Q11: A client is prescribed 250 mg of a medication available as a 125 mg/5 mL suspension. How many mL should be
given?
A. 5 mL
B. 2.5 mL
C. 10 mL [CORRECT]
D. 20 mL
Correct Answer: C
Rationale: 250 ÷ (125/5) = 250 ÷ 25 = 10 mL. The other options misapply the concentration.
Q12: A medication is ordered 0.25 g, and the tablet is 250 mg. How many tablets?
A. 2 tablets
B. 0.5 tablet
C. 4 tablets
D. 1 tablet [CORRECT]
Correct Answer: D
Rationale: 0.25 g = 250 mg, so 250 ÷ 250 = 1 tablet. The other options reflect conversion errors.
Q13: Which is an appropriate way to prevent a medication error?
A. Rushing administration
B. Using unlabeled syringes
C. Relying on memory
D. Verifying the rights and checking the label three times [CORRECT]
Correct Answer: D
Rationale: Verifying rights and checking the label reduces errors. Rushing, unlabeled syringes, and memory increase risk.
Q14: A client is prescribed 100 mg of a medication, and the vial contains 50 mg/mL. How many mL should be drawn
up?
Relias RN Pharmacology A - 2026/2027 Page 3
PROPHECY RN PHARMACOLOGY EXAM PRACTICE
2026/2027 EDITION
This is an independent practice exam for educational study; it is not an official ATI Testing proctored assessment.
Section Overview
This comprehensive online practice exam contains 110 questions across seven sections, aligned with the
Relias/Prophecy RN Pharmacology A competency blueprint, the current NCLEX-RN pharmacology standards, and
evidence-based medication administration practices for 2026/2027.
Sec Topic Qs
1 Medication Administration & Dosage Calculations - Oral, IV, Weight-Based 20
2 Cardiovascular & Anticoagulant Medications - Digoxin, Heparin, Warfarin 20
3 Antibiotics & Anti-infectives - Penicillins, Cephalosporins, Vancomycin 15
4 Endocrine & Metabolic Medications - Insulin, Glucocorticoids, Thyroid 15
5 Diuretics & Electrolyte Management - HCTZ, Spironolactone, Furosemide 10
6 Medication Safety & Adverse Effects - Interactions, Toxicity 15
7 Integrated Clinical Scenarios - Complex Patient Cases 15
TOTAL 110
Instructions
For each question, select the single best answer. Use the answer key at the end of the exam to check your work. Each
item includes a brief rationale explaining the correct response.
Answer Key Distribution: 28 A · 28 B · 27 C · 27 D
, Section 1: Medication Administration & Dosage Calculations - Oral, IV, and
Weight-Based Dosing
Q1: The 'Six Rights' of medication administration include which of the following?
A. Right client, room, bed, chair, door, and window
B. Right client, drug, dose, route, time, and documentation [CORRECT]
C. Right color, size, shape, taste, and smell
D. Right family, doctor, nurse, and pharmacist
Correct Answer: B
Rationale: The Six Rights include client, drug, dose, route, time, and documentation. The other options are incorrect.
Q2: A client is prescribed 500 mg of a medication, and the available tablet is 250 mg. How many tablets should be
given?
A. 1 tablet
B. 0.5 tablet
C. 4 tablets
D. 2 tablets [CORRECT]
Correct Answer: D
Rationale: 500 ÷ 250 = 2 tablets. The other options misapply the ratio.
Q3: A medication is ordered at 20 mg/kg for a client weighing 70 kg. The total dose is:
A. 1,400 mg [CORRECT]
B. 700 mg
C. 2,000 mg
D. 90 mg
Correct Answer: A
Rationale: 20 mg/kg × 70 kg = 1,400 mg. The other options misapply the calculation.
Q4: A client is prescribed 1,000 mL of IV fluid over 8 hours. The hourly rate is:
A. 100 mL/hour
B. 250 mL/hour
C. 125 mL/hour [CORRECT]
D. 1,000 mL/hour
Correct Answer: C
Rationale: 1,000 ÷ 8 = 125 mL/hour. The other options misapply the calculation.
Q5: An IV medication is ordered at 500 mg in 250 mL to infuse over 2 hours. The rate in mL/hour is:
A. 250 mL/hour
B. 50 mL/hour
C. 125 mL/hour [CORRECT]
D. 500 mL/hour
Correct Answer: C
Rationale: 250 mL ÷ 2 hours = 125 mL/hour. The other options misapply the calculation.
Q6: A client is prescribed 1500 mg of a medication that is available as 500 mg tablets. How many tablets?
A. 2 tablets
B. 5 tablets
C. 3 tablets [CORRECT]
D. 1 tablet
Correct Answer: C
Rationale: 1500 ÷ 500 = 3 tablets. The other options misapply the ratio.
Q7: Weight-based dosing is most commonly calculated using the client's:
A. Height
B. Age
Relias RN Pharmacology A - 2026/2027 Page 2
, C. Blood pressure
D. Weight in kilograms [CORRECT]
Correct Answer: D
Rationale: Weight-based dosing uses the client's weight in kilograms. The other factors are not the basis.
Q8: A medication is ordered at 5 mg/kg/day divided into two doses for a 60 kg client. Each dose is:
A. 150 mg [CORRECT]
B. 300 mg
C. 75 mg
D. 30 mg
Correct Answer: A
Rationale: Total daily = 5 × 60 = 300 mg; divided by 2 = 150 mg per dose. The other options are incorrect.
Q9: Which of the following is the correct abbreviation to avoid when documenting medication doses?
A. mg
B. mL
C. PO
D. 'U' for units (write 'units') [CORRECT]
Correct Answer: D
Rationale: 'U' is on the do-not-use list because it can be misread. mg, mL, and PO are acceptable when written correctly.
Q10: When calculating an IV infusion rate, the nurse uses:
A. The client's height
B. The room temperature
C. The client's age
D. The volume to be infused and the time over which it infuses [CORRECT]
Correct Answer: D
Rationale: IV rate is calculated from volume and time. The other factors are not used.
Q11: A client is prescribed 250 mg of a medication available as a 125 mg/5 mL suspension. How many mL should be
given?
A. 5 mL
B. 2.5 mL
C. 10 mL [CORRECT]
D. 20 mL
Correct Answer: C
Rationale: 250 ÷ (125/5) = 250 ÷ 25 = 10 mL. The other options misapply the concentration.
Q12: A medication is ordered 0.25 g, and the tablet is 250 mg. How many tablets?
A. 2 tablets
B. 0.5 tablet
C. 4 tablets
D. 1 tablet [CORRECT]
Correct Answer: D
Rationale: 0.25 g = 250 mg, so 250 ÷ 250 = 1 tablet. The other options reflect conversion errors.
Q13: Which is an appropriate way to prevent a medication error?
A. Rushing administration
B. Using unlabeled syringes
C. Relying on memory
D. Verifying the rights and checking the label three times [CORRECT]
Correct Answer: D
Rationale: Verifying rights and checking the label reduces errors. Rushing, unlabeled syringes, and memory increase risk.
Q14: A client is prescribed 100 mg of a medication, and the vial contains 50 mg/mL. How many mL should be drawn
up?
Relias RN Pharmacology A - 2026/2027 Page 3
