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Review Summary 180 Questions
Foundations - Application - BIO 210 Lecture UNIT 2 AND WITH Rationales JUST Released Pdfbio 210
Lecture 1- AND Correct WITH Rationales PDF Anatomy AND Physiology II BIO 210 Undergraduate YEAR 3 /
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All answers with rationales
,Table of Contents
Section A - Likely Section B - Explains
Questions 1 to 45 Questions 46 to 90
Section C - Directly Section D - Potential
Questions 91 to 135 Questions 136 to 180
,Section A - Likely
Q1.
A patient with a pituitary adenoma secretes excessive ACTH. Which of the following
laboratory findings would most likely be observed, and what is the primary mechanism?
A. Elevated cortisol with suppressed CRH B. Elevated cortisol with elevated CRH due
due to negative feedback on the to loss of negative feedback on the anterior
hypothalamus pituitary
C. Low cortisol with elevated ACTH due to D. Low cortisol with low ACTH due to
primary adrenal insufficiency exogenous corticosteroid use
Correct: A - Elevated cortisol with suppressed CRH due to negative feedback on the
hypothalamus
Rationale:Excessive ACTH from a pituitary adenoma stimulates the adrenal cortex to
produce cortisol, leading to elevated cortisol. The high cortisol then exerts negative feedback
on the hypothalamus, suppressing CRH secretion (and also on the anterior pituitary, but the
adenoma is autonomous). Thus, CRH is low, cortisol is high. Option B is incorrect because
CRH is suppressed, not elevated. Option C describes primary adrenal insufficiency, and D
describes secondary adrenal insufficiency from exogenous steroids.
Q2.
In cardiac muscle, which of the following best explains why the action potential plateau
phase is prolonged compared to skeletal muscle?
A. Rapid inactivation of voltage-gated B. Sustained opening of voltage-gated
sodium channels and sustained opening of sodium channels and delayed rectifier
calcium channels potassium channels
C. Influx of calcium through L-type channels D. Efflux of potassium through inward
balanced by efflux of potassium through rectifier channels and influx of sodium
delayed rectifier channels through funny channels
Correct: C - Influx of calcium through L-type channels balanced by efflux of potassium
through delayed rectifier channels
Rationale:The plateau phase of cardiac action potentials is due to a balance between inward
calcium current (through L-type calcium channels) and outward potassium current (through
delayed rectifier potassium channels). This prolongs depolarization, allowing for sustained
contraction. Option A is partially true but missing the potassium efflux. Option B is wrong
because sodium channels inactivate quickly. Option D is incorrect as funny channels are for
pacemaker potentials, not plateau.
Page 3
, Section A - Likely
Q3.
A researcher is studying a drug that irreversibly inhibits acetylcholinesterase at the
neuromuscular junction. Which of the following immediate effects would be expected on
muscle contraction?
A. Decreased muscle contraction due to B. Increased muscle contraction due to
receptor desensitization prolonged ACh action
C. No change in muscle contraction due to D. Muscle paralysis due to complete block
redundant degradation pathways of ACh release
Correct: B - Increased muscle contraction due to prolonged ACh action
Rationale:Inhibiting acetylcholinesterase prevents the breakdown of acetylcholine in the
synaptic cleft, leading to prolonged stimulation of nicotinic receptors and enhanced muscle
contraction. However, sustained exposure can eventually cause desensitization, but the
immediate effect is increased contraction. Option A is a later effect, not immediate. Option C
is incorrect because acetylcholinesterase is the primary degradation enzyme. Option D would
occur with botulinum toxin, not AChE inhibitors.
Q4.
A patient has a tumor that secretes excess aldosterone. Which set of laboratory findings
is most consistent with this condition?
A. Hypokalemia, metabolic alkalosis, B. Hyperkalemia, metabolic acidosis,
increased blood pressure, low renin decreased blood pressure, high renin
C. Hypokalemia, metabolic acidosis, D. Hyperkalemia, metabolic alkalosis,
increased blood pressure, high renin decreased blood pressure, low renin
Correct: A - Hypokalemia, metabolic alkalosis, increased blood pressure, low renin
Rationale:Excess aldosterone increases sodium reabsorption and potassium/hydrogen
secretion in the distal tubule, leading to hypokalemia, metabolic alkalosis, and hypertension.
Aldosterone secretion is independent of renin in an aldosterone-producing adenoma, so renin
is suppressed. Option B is consistent with hypoaldosteronism (e.g., Addison's). Option C has
high renin, which is not typical for primary aldosteronism. Option D has hyperkalemia and
alkalosis, which are contradictory.
Q5.
A patient has a condition that impairs the function of pulmonary surfactant. Which of the
following physiological changes would be most directly expected?
A. Increased lung compliance and increased B. Decreased lung compliance and
surface tension increased surface tension
Page 4