NURS 6630 PSYCHOPHARMACOLOGY ACTUAL FINALS QUESTIONS AND ANSWERS SET A.pdf

NURS 6630 PSYCHOPHARMACOLOGY ACTUAL
FINALS QUESTIONS AND ANSWERS SET A+
✔✔Combining these substances with Cytochrome P450 enzyme inhibitors can result in
severe respiratory depression and death due to toxic levels: - ✔✔Ethanol and sedative
hypnotics (benzos)

✔✔These two neuron types have abundant Alpha 2 receptors: - ✔✔Noradrenergic and
Serotonergic

✔✔When stimulated Alpha 2 receptors inhibit the activity of the presynaptic neuron and
decrease the release of these two neurotransmitters: - ✔✔Norepinephrine and
Serotonin

✔✔Six common Atypical Antidepressants used for individuals that did not respond to
other antidepressants: - ✔✔mirtazapine, trazadone, nefazodone, vilazodone,
vortioxetine, bupropion

✔✔This antidepressant effects Alpha 2 receptors, 5-HT2A receptors, 5-HT3A receptors,
and Histamine H1 receptors: - ✔✔mirtazapine

✔✔The primary antidepressant action of this drug comes from inhibition of the Alpha 2
receptors, which reduces the inhibition of the synaptic neuron, and thus increases
Norepinephrine and Serotonin release - ✔✔mirtazapine

✔✔As a Serotonin Antagonist, this Atypical Antidepressant blocks 5-HT2A and 5-HT3A
receptors to increase the amount of Serotonin available to bind to 5-HT1A receptors
which are more strongly linked to depression: - ✔✔mirtazapine

✔✔Mirtazapine's inhibition of 5-HT3A receptors reduces: - ✔✔nausea and vomiting

, ✔✔Mirtazapine's inhibition of Histamine H1 receptors causes: - ✔✔sedation (could be
desirable side effect for depressed individuals with insomnia)

✔✔For depressed individuals with anorexia, increased appetite and weight gain, are
possibly beneficial side effects of this Atypical Antidepressant: - ✔✔mirtazapine

✔✔As Serotonin Antagonists, these two Atypical Antidepressants block 5-HT2A
receptors so that more Serotonin is available to bind to 5-HT1A receptors which are
more strongly linked to depression: - ✔✔trazodone and nefazodone

✔✔In addition to inhibition of 5-HT2A receptors, these two Atypical Antidepressants
increase levels of Serotonin in the synaptic cleft through weak inhibition of Serotonin
reuptake transporters: - ✔✔trazodone and nefazodone

✔✔These two Atypical Antidepressants are strong H1 receptor inhibitors, and therefore
commonly used to treat insomnia: - ✔✔trazodone and nefazodone

✔✔These two Atypical Antidepressants may cause orthostatic hypotension and
priapism through Alpha-1 receptor inhibition: - ✔✔trazodone and nefazodone

✔✔In rare cases, this Atypical Antidepressant is known to cause severe liver damage: -
✔✔nefazodone

✔✔Similar to SSRIs, these two Atypical Antidepressants are strong inhibitors of
Serotonin reuptake transporters on the presynaptic neuron: - ✔✔vilazodone and
vortioxetine

✔✔These two Atypical Antidepressants bind to and stimulate 5-HT1A receptors: -
✔✔vilazodone (partial agonist) and vortioxetine (full agonist)

✔✔Vilazodone or Vortioxetine, which of these Atypical Antidepressants is a partial
agonist?: - ✔✔vilazodone

✔✔Vilazodone or Vortioxetine, which of these Atypical Antidepressants is a full
agonist?: - ✔✔vortioxetine

✔✔Since they enhance the effects of Serotonin through two different mechanisms,
these two Atypical Antidepressants can cause serotonin syndrome: - ✔✔vilazodone and
vortioxetine

✔✔Six common side effects of vilazodone (primarily anticholinergic, **unique to
vilazodone**): - ✔✔sedation, blurred vision, orthostatic hypotension, urinary retention,
tachycardia, **weight gain**