MMSC491 EXAM 3 QUESTIONS WITH VERIFIED
ANSWERS
59
00
1 of 59
Term
adenocarcinoma
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a malignant tumor of epithelial
a benign tumor of nervous tissue
origin
a malignant tumor of muscle tissue a benign tumor of connective tissue
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2 of 59
Term
,which if any of the following is false
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a) Mismatch repair is dedicated to repairing errors made during DNA replication.
b) MutSα is responsible for recognizing single base mismatches during DNA
replication.
c) MutSβ is responsible for recognizing all short insertion and deletion errors
made during DNA replication.
d) MutLα contributes an endonuclease activity that is required to nick the DNA
during DNA repair.
a) Conventional chromosome banding analyses are often very difficult to carry
out in the case of solid tumor samples.
b) Spectral karyotyping simply means standard chromosome FISH that is
applied to tumor cells.
c) Genomewide analyses can be carried out by microarray hybridization to
look for evidence of many types of chromosome abnormalities in solid
tumors.
d) Genomewide analyses cannot be carried out by chromosome FISH
analyses on cancer cell
a) It relies on surgical procedures to recover fetal tissues from a pregnant woman.
b) Chorion villus biopsies are typically taken around 16 weeks of gestation.
c) Amniotic fluid samples allow culturing of fetal cells for cytogenetic analyses as
well as allowing DNA analyses.
d) There is always a small excess risk of miscarriage
a) Epigenetic dysregulation is essentially a universal feature of tumors.
b) Epigenetic dysregulation in cancer cells always arises as a result of mutation at
a chromatin modifier locus.
c) There is an overall increase in DNA methylation across the genome of cancer
cells but with local DNA hypomethylation at the promoters of a few hundred
, genes.
d) Epigenetic dysregulation may sometimes initiate tumorigenesis.
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3 of 59
Term
Genetic procedure for B-thalassemia
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pre-symptomatic testing serum screening
diagnostic testing carrier screening
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4 of 59
Term
four types of role that biomarkers can have in cancer testing
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cytogenetic and DNA killing disease cells
, 1. diagnostic
2. predicitive
preimplantation
3. prognostic
4. disease monitoring
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5 of 59
Term
Which type of genetic abnormality is illustrated by the cartoon below
and is often associated with the development of cancer?
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translocation to produce a
deletion of a tumor suppressor gene
chimeric gene
point mutation in a proto-oncogene aneuploidy resulting in trisomy 21
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6 of 59
Definition
a) Mismatch repair is dedicated to repairing errors made during DNA
replication.
ANSWERS
59
00
1 of 59
Term
adenocarcinoma
Give this one a try later!
a malignant tumor of epithelial
a benign tumor of nervous tissue
origin
a malignant tumor of muscle tissue a benign tumor of connective tissue
Don't know?
2 of 59
Term
,which if any of the following is false
Give this one a try later!
a) Mismatch repair is dedicated to repairing errors made during DNA replication.
b) MutSα is responsible for recognizing single base mismatches during DNA
replication.
c) MutSβ is responsible for recognizing all short insertion and deletion errors
made during DNA replication.
d) MutLα contributes an endonuclease activity that is required to nick the DNA
during DNA repair.
a) Conventional chromosome banding analyses are often very difficult to carry
out in the case of solid tumor samples.
b) Spectral karyotyping simply means standard chromosome FISH that is
applied to tumor cells.
c) Genomewide analyses can be carried out by microarray hybridization to
look for evidence of many types of chromosome abnormalities in solid
tumors.
d) Genomewide analyses cannot be carried out by chromosome FISH
analyses on cancer cell
a) It relies on surgical procedures to recover fetal tissues from a pregnant woman.
b) Chorion villus biopsies are typically taken around 16 weeks of gestation.
c) Amniotic fluid samples allow culturing of fetal cells for cytogenetic analyses as
well as allowing DNA analyses.
d) There is always a small excess risk of miscarriage
a) Epigenetic dysregulation is essentially a universal feature of tumors.
b) Epigenetic dysregulation in cancer cells always arises as a result of mutation at
a chromatin modifier locus.
c) There is an overall increase in DNA methylation across the genome of cancer
cells but with local DNA hypomethylation at the promoters of a few hundred
, genes.
d) Epigenetic dysregulation may sometimes initiate tumorigenesis.
Don't know?
3 of 59
Term
Genetic procedure for B-thalassemia
Give this one a try later!
pre-symptomatic testing serum screening
diagnostic testing carrier screening
Don't know?
4 of 59
Term
four types of role that biomarkers can have in cancer testing
Give this one a try later!
cytogenetic and DNA killing disease cells
, 1. diagnostic
2. predicitive
preimplantation
3. prognostic
4. disease monitoring
Don't know?
5 of 59
Term
Which type of genetic abnormality is illustrated by the cartoon below
and is often associated with the development of cancer?
Give this one a try later!
translocation to produce a
deletion of a tumor suppressor gene
chimeric gene
point mutation in a proto-oncogene aneuploidy resulting in trisomy 21
Don't know?
6 of 59
Definition
a) Mismatch repair is dedicated to repairing errors made during DNA
replication.
