MMSC 491 EXAM 2 (PRACTICE AND QUIZZES)
QUESTIONS WITH VERIFIED ANSWERS
Correct 97
Incorrect
1 of 97
Term
With reference to aberrant methylation of bases which of the following
statements, if any, is false?
Give this one a try later!
Guanine is occasionally
. 3-methyladenine can be a cytotoxic
methylated to give O-6-
base: it distorts the double helix and
methylguanine which base pairs
that can disrupt crucial DNA-protein
with adenine rather than with
interactions.
cytidine.
S-adenosylmethionine donates
In each nucleated cell, about 300- methyl groups to a range of different
600 adenines are converted to 3- molecules in cells and frequently
methyladenine per day inappropriately methylates bases in
DNA.
, Don't know?
2 of 97
Term
Which of the following is a disease whose molecular basis is caused by
a gene-pseudo gene sequence exchange?
a. Steroid 21-hydroxylase deficiency
b. Hemophilia A
c. Sickle cell animia
d. Amyotrophic lateral sclerosis
Give this one a try later!
a. Steroid 21-hydroxylase
c. Huntington disease
deficiency
corrective surgery for cleft lip and
c. 46,XX,t(2;6)(q35;p21.3)
palete
Don't know?
3 of 97
Term
In cystic fibrosis, the p.Phe580del mutation leads to....
a. Abnormal regulation of gene expression.
,b. Aberant protein folding, leading to protein miss-folding and
improper cellular localizaiton.
c. Abnormal splicing.
d. Protein aggregation and cell lysis.
Give this one a try later!
b. Aberant protein folding,
a. histone acetylation always means
leading to protein miss-folding
adding an acetyl group to the side
and improper cellular
chain of a lysine residue.
localizaiton.
b. A position effect in which a gene is
c. A female with an interstitial deletion
silenced by an inversion where both
on the long arm of chromosome 15
breakpoints occur within a
with breakpoints at q11 and q13.
euchromatic environment.
Don't know?
4 of 97
Term
With reference to DNA repair, which of the following is false?
a. Crosslinking of bases on opposite DNA strands is especially
problematic for cells because it presents and obstacle to DNA
replication and the replication fork is stalled
b. Double strand DNA breaks are a challenge for cells because if
repair is not affected immediately the ends can drift apart quickly
making correct repair impossible
c. Crosslinking of bases on opposite DNA strands can be problematic
, for cells because it may present an obstacle to transcription and the
RNA polymerase is stalled
d. Repair of double stranded DNA breaks is easier in cells prior to DNA
replication than after DNA replication has occurred
Give this one a try later!
c. A female with an interstitial deletion on the long arm of chromosome 15 with
breakpoints at q11 and q13.
d. Repair of double stranded DNA breaks is easier in cells prior to DNA
replication than after DNA replication has occurred
B. The cross-linked bases are on opposing DNA strands.
c. The process involves epigenetic silencing of each gene on one of the two X
chromosomes, either the maternal X chromosome or the paternal X chromosome.
Don't know?
5 of 97
Term
The variable phenotype observed in the mitochondrial disease are due
to what genetic phenomena?
QUESTIONS WITH VERIFIED ANSWERS
Correct 97
Incorrect
1 of 97
Term
With reference to aberrant methylation of bases which of the following
statements, if any, is false?
Give this one a try later!
Guanine is occasionally
. 3-methyladenine can be a cytotoxic
methylated to give O-6-
base: it distorts the double helix and
methylguanine which base pairs
that can disrupt crucial DNA-protein
with adenine rather than with
interactions.
cytidine.
S-adenosylmethionine donates
In each nucleated cell, about 300- methyl groups to a range of different
600 adenines are converted to 3- molecules in cells and frequently
methyladenine per day inappropriately methylates bases in
DNA.
, Don't know?
2 of 97
Term
Which of the following is a disease whose molecular basis is caused by
a gene-pseudo gene sequence exchange?
a. Steroid 21-hydroxylase deficiency
b. Hemophilia A
c. Sickle cell animia
d. Amyotrophic lateral sclerosis
Give this one a try later!
a. Steroid 21-hydroxylase
c. Huntington disease
deficiency
corrective surgery for cleft lip and
c. 46,XX,t(2;6)(q35;p21.3)
palete
Don't know?
3 of 97
Term
In cystic fibrosis, the p.Phe580del mutation leads to....
a. Abnormal regulation of gene expression.
,b. Aberant protein folding, leading to protein miss-folding and
improper cellular localizaiton.
c. Abnormal splicing.
d. Protein aggregation and cell lysis.
Give this one a try later!
b. Aberant protein folding,
a. histone acetylation always means
leading to protein miss-folding
adding an acetyl group to the side
and improper cellular
chain of a lysine residue.
localizaiton.
b. A position effect in which a gene is
c. A female with an interstitial deletion
silenced by an inversion where both
on the long arm of chromosome 15
breakpoints occur within a
with breakpoints at q11 and q13.
euchromatic environment.
Don't know?
4 of 97
Term
With reference to DNA repair, which of the following is false?
a. Crosslinking of bases on opposite DNA strands is especially
problematic for cells because it presents and obstacle to DNA
replication and the replication fork is stalled
b. Double strand DNA breaks are a challenge for cells because if
repair is not affected immediately the ends can drift apart quickly
making correct repair impossible
c. Crosslinking of bases on opposite DNA strands can be problematic
, for cells because it may present an obstacle to transcription and the
RNA polymerase is stalled
d. Repair of double stranded DNA breaks is easier in cells prior to DNA
replication than after DNA replication has occurred
Give this one a try later!
c. A female with an interstitial deletion on the long arm of chromosome 15 with
breakpoints at q11 and q13.
d. Repair of double stranded DNA breaks is easier in cells prior to DNA
replication than after DNA replication has occurred
B. The cross-linked bases are on opposing DNA strands.
c. The process involves epigenetic silencing of each gene on one of the two X
chromosomes, either the maternal X chromosome or the paternal X chromosome.
Don't know?
5 of 97
Term
The variable phenotype observed in the mitochondrial disease are due
to what genetic phenomena?
