MMSC 433 EXAM 3 QUESTIONS & ANSWERS 2026-2027 | UPDATED & VERIFIED EXAM
P R O F E S S I O N A L P R A C T I C E M AT E R I A L S
MMSC 433 Exam 3
Questions & Answers 2026-
2027 | Updated & Verified
Verified Answers Exam Ready With Rationales
99 QUESTIONS
DOCUMENT OVERVIEW
This verified document provides 99 questions with their correct answers, covering hematologic
malignancies. It is suitable for exam study and review of key concepts in hematopathology. Students can
directly use these prepared Q&As to reinforce their understanding and prepare for assessments.
CONTENTS
Myeloproliferative Neoplasms (MPN) Q1–Q35
Lymphoid Neoplasms Q36–Q60
Myelodysplastic Syndromes (MDS) Q61–Q77
Acute Leukemias Q78–Q85
Plasma Cell Disorders Q86–Q98
General Hematology Concepts Q99–Q99
Page 1
, E XA M Q U EST I O N S
Q1 QUESTION 1 OF 99
Myeloproliferative disorders
CORRECT ANSWER
CML → Chronic Myeloid Leukemia
PV → Polycythemia Vera
ET → Essential Thrombocythemia
PMF → Primary Myelofibrosis
Q2 QUESTION 2 OF 99
CML
CORRECT ANSWER
-caused by (9;22) abnormality
-increase in myeloid cell line- cells that have granules
-kinase is not being turned off which is causing the increase in myeloid cells
Q3 QUESTION 3 OF 99
CML clinical features
CORRECT ANSWER
Anemia
Bleeding
Splenomegaly
Infections w/ strep pneumoniae
Q4 QUESTION 4 OF 99
Page 2
, CML chromosomal abnormality
CORRECT ANSWER
Philadelphia chromosome
Q5 QUESTION 5 OF 99
Philadelphia chromosome
CORRECT ANSWER
translocation of ABL from chromosome 9 to BCR of band q11 of chromosome 22
-abnormal fusion gene = BCR-ABL1
Q6 QUESTION 6 OF 99
Normal ABL gene
CORRECT ANSWER
functions as kinase (adds phosphate)
Q7 QUESTION 7 OF 99
normal BCR gene
CORRECT ANSWER
functions as GTPase activating protein (GAP)
-active when bound to GTP
Q8 QUESTION 8 OF 99
Page 3
P R O F E S S I O N A L P R A C T I C E M AT E R I A L S
MMSC 433 Exam 3
Questions & Answers 2026-
2027 | Updated & Verified
Verified Answers Exam Ready With Rationales
99 QUESTIONS
DOCUMENT OVERVIEW
This verified document provides 99 questions with their correct answers, covering hematologic
malignancies. It is suitable for exam study and review of key concepts in hematopathology. Students can
directly use these prepared Q&As to reinforce their understanding and prepare for assessments.
CONTENTS
Myeloproliferative Neoplasms (MPN) Q1–Q35
Lymphoid Neoplasms Q36–Q60
Myelodysplastic Syndromes (MDS) Q61–Q77
Acute Leukemias Q78–Q85
Plasma Cell Disorders Q86–Q98
General Hematology Concepts Q99–Q99
Page 1
, E XA M Q U EST I O N S
Q1 QUESTION 1 OF 99
Myeloproliferative disorders
CORRECT ANSWER
CML → Chronic Myeloid Leukemia
PV → Polycythemia Vera
ET → Essential Thrombocythemia
PMF → Primary Myelofibrosis
Q2 QUESTION 2 OF 99
CML
CORRECT ANSWER
-caused by (9;22) abnormality
-increase in myeloid cell line- cells that have granules
-kinase is not being turned off which is causing the increase in myeloid cells
Q3 QUESTION 3 OF 99
CML clinical features
CORRECT ANSWER
Anemia
Bleeding
Splenomegaly
Infections w/ strep pneumoniae
Q4 QUESTION 4 OF 99
Page 2
, CML chromosomal abnormality
CORRECT ANSWER
Philadelphia chromosome
Q5 QUESTION 5 OF 99
Philadelphia chromosome
CORRECT ANSWER
translocation of ABL from chromosome 9 to BCR of band q11 of chromosome 22
-abnormal fusion gene = BCR-ABL1
Q6 QUESTION 6 OF 99
Normal ABL gene
CORRECT ANSWER
functions as kinase (adds phosphate)
Q7 QUESTION 7 OF 99
normal BCR gene
CORRECT ANSWER
functions as GTPase activating protein (GAP)
-active when bound to GTP
Q8 QUESTION 8 OF 99
Page 3
