NURS 5357 Neurobiology
Comprehensive Resource To Help You Ace 2026-2027 Exams
Includes Frequently Tested Questions With ELABORATED
100% Correct COMPLETE SOLUTIONS
Guaranteed Pass First Attempt!! Current Update!!
1. What are the three major hypotheses of psychosis and their
neurotransmitter networks? - Correct Answer: Dopamine theory -
hyperactive dopamine at D2 receptors in the mesolimbic pathway
Glutamate theory - NMDA receptor hypofunction
Serotonin theory - 5HT2A receptor hyperfunction in the cortex
2. Briefly explain the dopamine hypothesis of the positive and negative
symptoms of schizophrenia. - Correct Answer: The dopamine
hypothesis of schizophrenia consists of: There is too much dopamine
activity in the mesolimbic dopamine pathway, which leads to positive
symptoms (such as hallucinations and delusions).
There is also too little dopamine activity in the mesocortical dopamine
pathway, which leads to negative symptoms (such as blunting of affect,
poverty of speech, anhedonia, and so on).
3. What pathway is responsible for regulating dopamine in the hypothalamus
and affects the release of prolactin? - Correct Answer:
Tuberoinfundibular pathway
4. Drug-induced Parkinson's is caused by a decrease of dopamine in what
pathway? - Correct Answer: Nigrostriatal pathway
,5. Brodmann's areas are differentiated by the: - Correct Answer: Cellular
architecture
6. All of the following are true about the hippocampus except that it: -
Correct Answer: Is disrupted by frontal lobotomy
7. Which of the following statements is true about the cerebellum: -
Correct Answer: Has been implicated in autism.
8. Cytokines are involved with all of the following except: - Correct
Answer: identifying T. pallidum
9. Which of the following is a possible explanation for schizophrenia: -
Correct Answer: Excessive pruning
10.Possible explanations for the role of thyroid hormone in mood disorders
include all of the following except: - Correct Answer: Changes in GR's
11.All of the following are plausible theories on the etiology of schizophrenia
except? - Correct Answer: Dopamine hypothesis
12.Auditory hallucinations have been shown to activate which region on fMRI?
- Correct Answer: Superior temporal lobe
, 13.All of the following suggest white matter impairment in schizophrenia
except? - Correct Answer: Significantly reduced white matter volume
14.Evidence that GABA interneurons are impaired in schizophrenia -
Correct Answer: Reduced GAD67
15.All of the following support the reduced neuropil hypothesis except? -
Correct Answer: oligodendrocyte dysfunction
16.Evidence that schizophrenia is a biological disorder includes all of the
following except? - Correct Answer: Gliosis in the prefrontal cortex
17.Neurodevelopmental causes that could explain schizophrenia include
excessive amounts of all of the following except: - Correct Answer:
Myelination
18.The NP's discuss a patient diagnosed with schizophrenia. The PMHNP
knows that which of the following groups of symptoms is most likely to be
categorized as "negative symptoms" of schizophrenia? - Correct
Answer: Blunted affect, poor rapport, lack of spontaneity
19.There is a genetic contribution to some, perhaps all, forms of schizophrenia.
In the case of monozygotic twins who have identical genetic makeup, there
is an approximately 50 percent chance for them to develop schizophrenia. -
Correct Answer: True
Comprehensive Resource To Help You Ace 2026-2027 Exams
Includes Frequently Tested Questions With ELABORATED
100% Correct COMPLETE SOLUTIONS
Guaranteed Pass First Attempt!! Current Update!!
1. What are the three major hypotheses of psychosis and their
neurotransmitter networks? - Correct Answer: Dopamine theory -
hyperactive dopamine at D2 receptors in the mesolimbic pathway
Glutamate theory - NMDA receptor hypofunction
Serotonin theory - 5HT2A receptor hyperfunction in the cortex
2. Briefly explain the dopamine hypothesis of the positive and negative
symptoms of schizophrenia. - Correct Answer: The dopamine
hypothesis of schizophrenia consists of: There is too much dopamine
activity in the mesolimbic dopamine pathway, which leads to positive
symptoms (such as hallucinations and delusions).
There is also too little dopamine activity in the mesocortical dopamine
pathway, which leads to negative symptoms (such as blunting of affect,
poverty of speech, anhedonia, and so on).
3. What pathway is responsible for regulating dopamine in the hypothalamus
and affects the release of prolactin? - Correct Answer:
Tuberoinfundibular pathway
4. Drug-induced Parkinson's is caused by a decrease of dopamine in what
pathway? - Correct Answer: Nigrostriatal pathway
,5. Brodmann's areas are differentiated by the: - Correct Answer: Cellular
architecture
6. All of the following are true about the hippocampus except that it: -
Correct Answer: Is disrupted by frontal lobotomy
7. Which of the following statements is true about the cerebellum: -
Correct Answer: Has been implicated in autism.
8. Cytokines are involved with all of the following except: - Correct
Answer: identifying T. pallidum
9. Which of the following is a possible explanation for schizophrenia: -
Correct Answer: Excessive pruning
10.Possible explanations for the role of thyroid hormone in mood disorders
include all of the following except: - Correct Answer: Changes in GR's
11.All of the following are plausible theories on the etiology of schizophrenia
except? - Correct Answer: Dopamine hypothesis
12.Auditory hallucinations have been shown to activate which region on fMRI?
- Correct Answer: Superior temporal lobe
, 13.All of the following suggest white matter impairment in schizophrenia
except? - Correct Answer: Significantly reduced white matter volume
14.Evidence that GABA interneurons are impaired in schizophrenia -
Correct Answer: Reduced GAD67
15.All of the following support the reduced neuropil hypothesis except? -
Correct Answer: oligodendrocyte dysfunction
16.Evidence that schizophrenia is a biological disorder includes all of the
following except? - Correct Answer: Gliosis in the prefrontal cortex
17.Neurodevelopmental causes that could explain schizophrenia include
excessive amounts of all of the following except: - Correct Answer:
Myelination
18.The NP's discuss a patient diagnosed with schizophrenia. The PMHNP
knows that which of the following groups of symptoms is most likely to be
categorized as "negative symptoms" of schizophrenia? - Correct
Answer: Blunted affect, poor rapport, lack of spontaneity
19.There is a genetic contribution to some, perhaps all, forms of schizophrenia.
In the case of monozygotic twins who have identical genetic makeup, there
is an approximately 50 percent chance for them to develop schizophrenia. -
Correct Answer: True
