NBME CBSE FORM 6 COMPREHENSIVE
EXAM SCRIPT 2026 FULL QUESTIONS AND
ANSWERS
◉ What are common findings in a patient with Cushing's syndrome?
Answer: Hypertension and muscle weakness, along with wide red
streaks (striae) and moon face.
◉ What is the likely diagnosis for a boy with knee pain and an
abnormal anterior tibial area?
Answer: Osgood-Schlatter disease, associated with patellar ligament
attachment.
◉ What environmental exposure increases the risk for lung cancer
in a 65-year-old man?
Answer: Radon exposure, commonly found in basements.
◉ What brain structure is stimulated in response to intense fear?
Answer: The amygdala, which is responsible for processing fear.
◉ What is the clinical phenotype of a patient with a CFTR mutation
G551D?
,Answer: Recurrent upper respiratory infections and salty sweat,
indicative of cystic fibrosis.
◉ What is the appropriate response for a physician to a patient
expressing grief over a deceased daughter?
Answer: Express empathy by acknowledging the patient's loss and
inviting them to share memories.
◉ What is the significance of transference in a medical context?
Answer: Transference refers to the patient's feelings and attitudes
towards the healthcare provider, which can impact their treatment
and relationship.
◉ What is the normal developmental stage associated with
gynecomastia in males?
Answer: Gynecomastia is considered a normal development during
puberty in males.
◉ What is a common abnormal movement in a 32-year-old male
when feeling angry?
Answer: The individual may exhibit abnormal movements in the
hands and have difficulty fixing his gaze.
,◉ What anatomical abnormalities are likely in a patient with
difficulty controlling gaze?
Answer: Anatomical abnormalities are likely in the basal ganglia.
◉ What is the most likely cardiac finding in a child with recurrent
otitis media?
Answer: Normal findings are expected during cardiac auscultation.
◉ What is the most specific indicator of pulmonary arterial
hypertension in a patient with sudden shortness of breath?
Answer: A P2 sound louder than A2 is the most specific indicator.
◉ What is the cause of nausea and vomiting after drinking
champagne in a patient treated for Trichomonas vaginalis infection?
Answer: The cause is likely the accumulation of acetaldehyde due to
a disulfiram-like reaction with metronidazole.
◉ What is the mechanism of vincristine that leads to numbness in
feet?
Answer: Vincristine causes depolymerization of microtubules.
◉ What does a single nucleotide change in the FBN1 gene indicate?
Answer: It indicates a polymorphism that does not change the amino
acid at the locus.
, ◉ What is the appropriate response to a patient waiting for an
appointment?
Answer: A suitable remark is: 'Thank you for waiting. How can I help
you today?'
◉ What physiological changes occur in a patient who has been shot
and presents with increased pulse and decreased blood pressure?
Answer: Baroreceptor firing decreases, systemic vascular resistance
increases, and pulmonary vascular resistance increases.
◉ What area is indicated by fluid in the abdomen in a patient with
hemorrhagic shock?
Answer: The omental bursa (lesser sac) is indicated.
◉ What is the positive predictive value of a test if the probability of a
patient with a positive test having a disease is 0.67?
Answer: The positive predictive value is 0.67.
◉ What is the most appropriate interpreter for a 75-year-old
woman with T2DM and HTN who emigrated from Argentina?
Answer: A telephone interpreter is the most appropriate.
EXAM SCRIPT 2026 FULL QUESTIONS AND
ANSWERS
◉ What are common findings in a patient with Cushing's syndrome?
Answer: Hypertension and muscle weakness, along with wide red
streaks (striae) and moon face.
◉ What is the likely diagnosis for a boy with knee pain and an
abnormal anterior tibial area?
Answer: Osgood-Schlatter disease, associated with patellar ligament
attachment.
◉ What environmental exposure increases the risk for lung cancer
in a 65-year-old man?
Answer: Radon exposure, commonly found in basements.
◉ What brain structure is stimulated in response to intense fear?
Answer: The amygdala, which is responsible for processing fear.
◉ What is the clinical phenotype of a patient with a CFTR mutation
G551D?
,Answer: Recurrent upper respiratory infections and salty sweat,
indicative of cystic fibrosis.
◉ What is the appropriate response for a physician to a patient
expressing grief over a deceased daughter?
Answer: Express empathy by acknowledging the patient's loss and
inviting them to share memories.
◉ What is the significance of transference in a medical context?
Answer: Transference refers to the patient's feelings and attitudes
towards the healthcare provider, which can impact their treatment
and relationship.
◉ What is the normal developmental stage associated with
gynecomastia in males?
Answer: Gynecomastia is considered a normal development during
puberty in males.
◉ What is a common abnormal movement in a 32-year-old male
when feeling angry?
Answer: The individual may exhibit abnormal movements in the
hands and have difficulty fixing his gaze.
,◉ What anatomical abnormalities are likely in a patient with
difficulty controlling gaze?
Answer: Anatomical abnormalities are likely in the basal ganglia.
◉ What is the most likely cardiac finding in a child with recurrent
otitis media?
Answer: Normal findings are expected during cardiac auscultation.
◉ What is the most specific indicator of pulmonary arterial
hypertension in a patient with sudden shortness of breath?
Answer: A P2 sound louder than A2 is the most specific indicator.
◉ What is the cause of nausea and vomiting after drinking
champagne in a patient treated for Trichomonas vaginalis infection?
Answer: The cause is likely the accumulation of acetaldehyde due to
a disulfiram-like reaction with metronidazole.
◉ What is the mechanism of vincristine that leads to numbness in
feet?
Answer: Vincristine causes depolymerization of microtubules.
◉ What does a single nucleotide change in the FBN1 gene indicate?
Answer: It indicates a polymorphism that does not change the amino
acid at the locus.
, ◉ What is the appropriate response to a patient waiting for an
appointment?
Answer: A suitable remark is: 'Thank you for waiting. How can I help
you today?'
◉ What physiological changes occur in a patient who has been shot
and presents with increased pulse and decreased blood pressure?
Answer: Baroreceptor firing decreases, systemic vascular resistance
increases, and pulmonary vascular resistance increases.
◉ What area is indicated by fluid in the abdomen in a patient with
hemorrhagic shock?
Answer: The omental bursa (lesser sac) is indicated.
◉ What is the positive predictive value of a test if the probability of a
patient with a positive test having a disease is 0.67?
Answer: The positive predictive value is 0.67.
◉ What is the most appropriate interpreter for a 75-year-old
woman with T2DM and HTN who emigrated from Argentina?
Answer: A telephone interpreter is the most appropriate.
