NUR 555 Quiz 3:Hematologic &
Integumentary Disorders | Full Questions
and Answers with rationales | 2026
Updated | 100% Correct - SNHU
SECTION 1: HEMATOLOGIC DISORDERS
Question 1
A patient with pernicious anemia is at risk for which complication due to vitamin B12
deficiency?
A) Iron overload
B) Subacute combined degeneration of the spinal cord
C) Hemolytic crisis
D) Thrombocytosis
Answer: B
Rationale: Pernicious anemia involves vitamin B12 deficiency due to lack of intrinsic
factor. B12 is essential for myelin synthesis, and deficiency causes progressive
demyelination of the dorsal and lateral columns of the spinal cord, leading to subacute
combined degeneration with sensory ataxia and spasticity .
Question 2
, A patient's complete blood count shows macrocytic anemia and hypersegmented
neutrophils. Which deficiency is most likely?
A) Iron deficiency
B) Vitamin B12 or folate deficiency
C) Vitamin K deficiency
D) Copper deficiency
Answer: B
Rationale: Macrocytic anemia (elevated MCV) with hypersegmented neutrophils is the
classic hallmark of megaloblastic anemia caused by vitamin B12 or folate deficiency.
Megaloblastic erythropoiesis produces enlarged red blood cell precursors with nuclear
maturation defects .
Question 3
The mechanism by which vitamin B12 is absorbed requires:
A) Bile salts
B) Intrinsic factor produced by gastric parietal cells
C) Pancreatic enzymes
D) Vitamin C
Answer: B
Rationale: Vitamin B12 requires intrinsic factor, a glycoprotein secreted by gastric
parietal cells, for absorption in the terminal ileum. Pernicious anemia occurs when
autoimmune destruction of parietal cells leads to intrinsic factor deficiency .
Question 4
A patient with anemia has laboratory findings of microcytic, hypochromic red blood
cells. Which condition is the most likely cause?
Integumentary Disorders | Full Questions
and Answers with rationales | 2026
Updated | 100% Correct - SNHU
SECTION 1: HEMATOLOGIC DISORDERS
Question 1
A patient with pernicious anemia is at risk for which complication due to vitamin B12
deficiency?
A) Iron overload
B) Subacute combined degeneration of the spinal cord
C) Hemolytic crisis
D) Thrombocytosis
Answer: B
Rationale: Pernicious anemia involves vitamin B12 deficiency due to lack of intrinsic
factor. B12 is essential for myelin synthesis, and deficiency causes progressive
demyelination of the dorsal and lateral columns of the spinal cord, leading to subacute
combined degeneration with sensory ataxia and spasticity .
Question 2
, A patient's complete blood count shows macrocytic anemia and hypersegmented
neutrophils. Which deficiency is most likely?
A) Iron deficiency
B) Vitamin B12 or folate deficiency
C) Vitamin K deficiency
D) Copper deficiency
Answer: B
Rationale: Macrocytic anemia (elevated MCV) with hypersegmented neutrophils is the
classic hallmark of megaloblastic anemia caused by vitamin B12 or folate deficiency.
Megaloblastic erythropoiesis produces enlarged red blood cell precursors with nuclear
maturation defects .
Question 3
The mechanism by which vitamin B12 is absorbed requires:
A) Bile salts
B) Intrinsic factor produced by gastric parietal cells
C) Pancreatic enzymes
D) Vitamin C
Answer: B
Rationale: Vitamin B12 requires intrinsic factor, a glycoprotein secreted by gastric
parietal cells, for absorption in the terminal ileum. Pernicious anemia occurs when
autoimmune destruction of parietal cells leads to intrinsic factor deficiency .
Question 4
A patient with anemia has laboratory findings of microcytic, hypochromic red blood
cells. Which condition is the most likely cause?
