UNIVERSITY OF SOUTH ALABAMA · COLLEGE OF NURSING
NU 578 Advanced
Pharmacology
Practice Question Bank
Exam-Style Practice Questions with Rationales
Topic Focus: Advanced Pharmacology — Comprehensive Review
Edition 1 · July 2026
Table of Contents
1. Instructions for Use 2
2. Practice Questions with Answers & Rationales — Advanced Pharmacology 2
University of South Alabama · College of Nursing Page 1
,NU 578 ADVANCED PHARMACOLOGY PRACTICE GUIDE INSTRUCTIONS & PRACTICE QUESTIONS
How to Use This Guide
Read each stem, choose your answer, then check the rationale directly below it. The correct
option is marked, and each wrong option is explained so you understand why it's wrong — not
just that it is. These questions are designed to reflect the NU 578 Advanced Pharmacology
exam style and content.
Category: Advanced Pharmacology — NU 578
1 The Pure Food and Drug Act of 1906 primarily:
A Enforced drug strength and purity and prohibited mislabeling or adulteration
B Required proof of drug efficacy before marketing
C Established the DEA
D Separated OTC from prescription drugs
Why A is correct: The Pure Food and Drug Act of 1906 enforced drug strength and purity,
prohibited mislabeling or adulteration, and established the basis for drug recalls. It did not
require proof of efficacy—that came later with the Kefauver-Harris Amendments.
B — Proof of efficacy was mandated by the Kefauver-Harris Amendments of 1962.
C — The DEA was established by the Comprehensive Drug Abuse Prevention and Control Act
of 1970.
D — The separation of OTC and prescription drugs was established by the Durham-
Humphrey Amendments of 1952.
, 2 The Harrison Narcotic Act of 1914 regulated which substances?
A Opium, cocaine, and marijuana
B Alcohol and tobacco
C Benzodiazepines and barbiturates
D Amphetamines and steroids
Why A is correct: The Harrison Narcotic Act of 1914 regulated opium, cocaine, and
marijuana. It was later replaced by the Controlled Substance Act of 1970.
B — Alcohol and tobacco were not regulated by the Harrison Narcotic Act.
C — Benzodiazepines and barbiturates were regulated under later legislation.
D — Amphetamines and steroids were regulated under later legislation.
3 The Food, Drug, and Cosmetic Act of 1938 mandated:
A Safety of drugs, not effectiveness
B Both safety and effectiveness of drugs
C Proof of efficacy before marketing
D The creation of the DEA
Why A is correct: The Food, Drug, and Cosmetic Act of 1938 mandated safety, not
effectiveness. It was enforced by the FDA through registration of all parties involved in the
manufacture, sale, and distribution of drugs.
B — Both safety and effectiveness were mandated by the Kefauver-Harris Amendments of
1962.
C — Proof of efficacy was required by the Kefauver-Harris Amendments of 1962.
D — The DEA was established in 1970.
NU 578 Advanced
Pharmacology
Practice Question Bank
Exam-Style Practice Questions with Rationales
Topic Focus: Advanced Pharmacology — Comprehensive Review
Edition 1 · July 2026
Table of Contents
1. Instructions for Use 2
2. Practice Questions with Answers & Rationales — Advanced Pharmacology 2
University of South Alabama · College of Nursing Page 1
,NU 578 ADVANCED PHARMACOLOGY PRACTICE GUIDE INSTRUCTIONS & PRACTICE QUESTIONS
How to Use This Guide
Read each stem, choose your answer, then check the rationale directly below it. The correct
option is marked, and each wrong option is explained so you understand why it's wrong — not
just that it is. These questions are designed to reflect the NU 578 Advanced Pharmacology
exam style and content.
Category: Advanced Pharmacology — NU 578
1 The Pure Food and Drug Act of 1906 primarily:
A Enforced drug strength and purity and prohibited mislabeling or adulteration
B Required proof of drug efficacy before marketing
C Established the DEA
D Separated OTC from prescription drugs
Why A is correct: The Pure Food and Drug Act of 1906 enforced drug strength and purity,
prohibited mislabeling or adulteration, and established the basis for drug recalls. It did not
require proof of efficacy—that came later with the Kefauver-Harris Amendments.
B — Proof of efficacy was mandated by the Kefauver-Harris Amendments of 1962.
C — The DEA was established by the Comprehensive Drug Abuse Prevention and Control Act
of 1970.
D — The separation of OTC and prescription drugs was established by the Durham-
Humphrey Amendments of 1952.
, 2 The Harrison Narcotic Act of 1914 regulated which substances?
A Opium, cocaine, and marijuana
B Alcohol and tobacco
C Benzodiazepines and barbiturates
D Amphetamines and steroids
Why A is correct: The Harrison Narcotic Act of 1914 regulated opium, cocaine, and
marijuana. It was later replaced by the Controlled Substance Act of 1970.
B — Alcohol and tobacco were not regulated by the Harrison Narcotic Act.
C — Benzodiazepines and barbiturates were regulated under later legislation.
D — Amphetamines and steroids were regulated under later legislation.
3 The Food, Drug, and Cosmetic Act of 1938 mandated:
A Safety of drugs, not effectiveness
B Both safety and effectiveness of drugs
C Proof of efficacy before marketing
D The creation of the DEA
Why A is correct: The Food, Drug, and Cosmetic Act of 1938 mandated safety, not
effectiveness. It was enforced by the FDA through registration of all parties involved in the
manufacture, sale, and distribution of drugs.
B — Both safety and effectiveness were mandated by the Kefauver-Harris Amendments of
1962.
C — Proof of efficacy was required by the Kefauver-Harris Amendments of 1962.
D — The DEA was established in 1970.
