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1. Cholelithiasis - ANSWER ✔ Supersaturation of bile w/ cholesterol causing
nucleation of crystals and hypomotility allowing stone growth
♦ Nucleation occurs where the cholesterol crystals aggregate together.
Continued growth of the crystals then depends on the balance between
cholesterol growth
♦ What would you see in your patient with this?
• Intermittent biliary colic, persistent epigastric or RU abdominal pain
• N/V, sweating, flatus, pain radiates to the back
• May be precipitated by a meal, may manifest at night
♦ What would you teach your patient about what this is?
• Need to worry about bile and cholesterol
• No fatty foods, avoid alcohol,
• Somatostatin---esophgeal varices -do not give
• Not going to have somatostatin
2. Cholecystitis - ANSWER ✔ Acute inflammation of the gallbladder wall—
obstruction of cystic duct=statis of bile in gallbladder
♦ What are the risk factors?
• Diabetes and obesity
♦ What would you see in your patient with this?
• Severe right upper abdominal pain that radiates to the back,
abdominal tenderness, fever
♦ What testing should you anticipate?
• Leukocytosis, mild elevations in bilirubin,
• Ultrasound, CT, ERCP, no biopsy
• Increased risk of cancer
• Huge risk for sepsis
,3. Hepatitis A - ANSWER ✔ enteric hepatitis -RNA virus
♦ Fecal-oral route—lack of sanitation and safe water
♦ 2-7-week incubation period
♦ Malaise, anorexia, nausea, low grade fever, RUQ pain, with or without
jaundice
♦ Anti-HAV IgM =acute infection
♦ Anti-HAV IgG= previous infection or vaccination
• immunity
♦ Supportive management—avoid alcohol and NSAIDs
• Vaccination
4. Hypothyroidism - ANSWER ✔ Decreased basal metabolism, weakness,
lethargy, cold intolerance, decreased appetite, bradycardia, narrowed pulse
pressure, elevated levels of serum cholesterol and triglycerides, constipation,
cool dry skin, heavy periods
♦ Slow and low, heavy periods
5. Hyperthyroidism - ANSWER ✔ Increased metabolic rate, insomnia,
restlessness, tremor, irritability, palpitations, increased HR, heat intolerance,
diaphoresis, weight loss, amenorrhea,
6. Primary hypothyroidism - ANSWER ✔ Congenital agenesis, autoimmune
destruction, irradiation, trauma, surgical removal of the gland, iodine
deficiency
♦ Secondary?
• Caused by defects in TSH production—severe head trauma, cranial
neoplasms, brain infections, cranial irradiation, TBIs
7. Cushing syndrome (hypercortisolism) - ANSWER ✔ Hyperfunction of the
adrenal cortex results in conditions characterized by hypercortisolism
♦ What would you see in your patient with this?
• Moon face, weight gain, dorsocervical fat pad, capillary friability,
thinning of the skin with purple striae, ecchymoses over abdomen,
arm and thighs
• Hypertension—consequence of salt retaining activity of cortisol and
of the increased blood volume
• Reduction of serum potassium level because of excessive excretion of
potassium by the kidneys, hyperglycemia, elevated cortisol levels
• Excessive hair production
,♦ What can cause this?
• Primary—disease of the adrenal cortex—low ACTH
• Secondary- hyperfunction of anterior pituitary ACTH-secreting cells,
and tertiary disease is caused by hypothalamic dysfunction or injury
♦ What might you test?
• Serum ACTH
• Dexamethasone suppression test will be used to differentiate between
pituitary causes and ectopic causes of excessive ACTH production
8. a disease of the adrenal cortex resulting in conditions characterized by
hypercortisolism - ANSWER ✔ Cushing syndrome
9. primary: caused by disease of adrenal cortex (adrenal adenoma) Secondary:
caused by ACTH secreting cells, Tertiary: caused by hypothalamic
dysfunction or injury - ANSWER ✔ Cushing syndrome
10.clinical manifestations: truncal obesity, moon face, flushed cheeks, muscle
wasting, petechia, risk for fracture, depression and anxiety - ANSWER ✔
Cushing syndrome
11.labs will show hyperglycemia, hypokalemia, elevated serum cortisol -
ANSWER ✔ cushing syndrome
12.type I hypersensitivity= - ANSWER ✔ anaphylaxis
13.type II hypersinsitivity= - ANSWER ✔ transfusion reaction
14.type IIb hypersensitivity= - ANSWER ✔ graves disease
15.type III hypersensitivity complex glomerulonephritis can be related to... -
ANSWER ✔ dormant bacterial infecton
16.type IV hypersensitivity= - ANSWER ✔ TB test
17.Myxedema coma is a severe condition associated with
a. hypothyroidism.
b. restlessness.
, c. acute cortisol insufficiency.
d. pheochromocytoma. - ANSWER ✔ a. Hypothyroidism
18.Clinical manifestations of hypoparathyroidism
a. are similar to those occurring with hypermagnesemia.
b. result from decreased neuromuscular excitability.
c. are similar to those occurring with hypokalemia.
d. result from decreased serum ionized calcium. - ANSWER ✔
d. result from decreased serum ionized calcium.
19.The formation of active vitamin D
a. occurs in the skin.
b. is impaired in renal failure.
c. is dependent on oral intake of vitamin D.
d. is necessary for normal potassium metabolism. - ANSWER
✔ b. is impaired in renal failure
20.Aldosterone secretion is regulated by the presence of - in the circulation.
a. progesterone
b. corticoglobulin
c. ACTH
d. angiotensin II - ANSWER ✔ d. angiotensin II
21.A clinical finding that is consistent with a diagnosis of adrenocortical
insufficiency is
a. hypokalemia.
b. hypoglycemia.
c. hypertension.
d. moon face. - ANSWER ✔ b. Hypoglycemia
22.What effect would adrenocortical insufficiency have on an individual's
response to surgical stress?
a. More prone to hyperglycemia
b. Exaggerated sensitivity to anesthesia