NRl 507/l NR507l Midterml Exam:l
Advancedl Pathophysiologyl Reviewl (Latestl
2026/l 2027l Update)l |l Qsl &l As|l Gradel A|l
100%l Correctl (Verifiedl Answers)-l
Chamberlain
QUESTION
Typel 1l Hypersensitivity
Answer:
Allergicl Reaction
Mediatedl byl IgE
Inflammationl d/tl mastl celll degranulation
Locall symptoms:l itching,l rash
Systemicl symptoms:l wheezing
QUESTION
Mostl dangerousl forml ofl Typel 1l Hypersensitivityl andl treatment:
Answer:
Anaphylacticl reaction-systemicl response-hypotension,l severel bronchoconstriction
Treatment:l Epinephrine
QUESTION
Typel 2l Hypersensitivity
Answer:
Cytotoxicl reaction;l tissuel specific
Macrophagesl arel thel primaryl effectorl cells
,QUESTION
Examplesl ofl Typel 2l Hypersensitivity
Answer:
Bloodl transfusionsl whenl wrongl bloodl given,l hemolyticl diseasel ofl newbornl whenl moml
andl babyl havel differentl bloodl types,l causingl thel mother'sl bloodl tol attackl fetus,l Gravesl
disease,l Myasthenial gravis
QUESTION
Gravesl Disease
Answer:
Immunel systeml producesl autoantibodiesl (thyroid-stimulatingl immunoglobulinsl TSI's)l thatl
targetl andl bindl tol thel thyroid-stimulatingl hormonel (TSH)l receptorsl onl thyroidl cells
Thisl bindingl stimulatesl thel thyroidl glandl tol producel andl releasel excessivel thyroidl
hormonesl (T3l andl T4)l inl thel absencel ofl TSH.
QUESTION
Keyl characteristicsl ofl Gravesl Diseasel asl al Typel 2l Reaction:
Answer:
Autoantibody-Mediated
Stimulatory,l notl cytotoxic
QUESTION
Commonl symptomsl ofl Gravesl disease
Answer:
hyperthyroidism-increasel metabolism,l sweating,l tremors,l andl bulgingl eyesl (exophthalmos)
QUESTION
Typel 3l hypersensitivity
, Answer:
immunel responsesl inl whichl antigen-antibodyl complexesl forml inl thel bloodl andl depositl
inl variousl tissues
IgGl orl IgM
Inflammationl andl Tissuel damage
QUESTION
Commonl sitesl ofl depositionl ofl typel 3l hypersensitivity
Answer:
kidneys,l lungs,l skin,l andl joints,l leadingl tol inflammationl andl damagel inl thesel areas.
QUESTION
Differencel betweenl typel 2l andl typel 3l hypersensitivity
Answer:
Typel 2l isl organl specific,l antibodyl bindsl tol thel antigenl onl thel celll surface
Typel 3l inl notl organl specific,l antibodyl bindsl tol solublel antigenl outsidel thel celll surfacel
thatl wasl releasedl intol thel bloodl orl bodyl fluidsl andl thenl depositedl inl thel tissues
QUESTION
Typel 3l hypersensitivityl Examples
Answer:
systemicl lupusl erythematosus,l rheumatoidl arthritis
QUESTION
Systemicl Lupusl Erythematosusl flare-upl triggers
Answer:
Stress,l infections,l sunlight,l hormonall changes,l orl certainl medications
QUESTION
Advancedl Pathophysiologyl Reviewl (Latestl
2026/l 2027l Update)l |l Qsl &l As|l Gradel A|l
100%l Correctl (Verifiedl Answers)-l
Chamberlain
QUESTION
Typel 1l Hypersensitivity
Answer:
Allergicl Reaction
Mediatedl byl IgE
Inflammationl d/tl mastl celll degranulation
Locall symptoms:l itching,l rash
Systemicl symptoms:l wheezing
QUESTION
Mostl dangerousl forml ofl Typel 1l Hypersensitivityl andl treatment:
Answer:
Anaphylacticl reaction-systemicl response-hypotension,l severel bronchoconstriction
Treatment:l Epinephrine
QUESTION
Typel 2l Hypersensitivity
Answer:
Cytotoxicl reaction;l tissuel specific
Macrophagesl arel thel primaryl effectorl cells
,QUESTION
Examplesl ofl Typel 2l Hypersensitivity
Answer:
Bloodl transfusionsl whenl wrongl bloodl given,l hemolyticl diseasel ofl newbornl whenl moml
andl babyl havel differentl bloodl types,l causingl thel mother'sl bloodl tol attackl fetus,l Gravesl
disease,l Myasthenial gravis
QUESTION
Gravesl Disease
Answer:
Immunel systeml producesl autoantibodiesl (thyroid-stimulatingl immunoglobulinsl TSI's)l thatl
targetl andl bindl tol thel thyroid-stimulatingl hormonel (TSH)l receptorsl onl thyroidl cells
Thisl bindingl stimulatesl thel thyroidl glandl tol producel andl releasel excessivel thyroidl
hormonesl (T3l andl T4)l inl thel absencel ofl TSH.
QUESTION
Keyl characteristicsl ofl Gravesl Diseasel asl al Typel 2l Reaction:
Answer:
Autoantibody-Mediated
Stimulatory,l notl cytotoxic
QUESTION
Commonl symptomsl ofl Gravesl disease
Answer:
hyperthyroidism-increasel metabolism,l sweating,l tremors,l andl bulgingl eyesl (exophthalmos)
QUESTION
Typel 3l hypersensitivity
, Answer:
immunel responsesl inl whichl antigen-antibodyl complexesl forml inl thel bloodl andl depositl
inl variousl tissues
IgGl orl IgM
Inflammationl andl Tissuel damage
QUESTION
Commonl sitesl ofl depositionl ofl typel 3l hypersensitivity
Answer:
kidneys,l lungs,l skin,l andl joints,l leadingl tol inflammationl andl damagel inl thesel areas.
QUESTION
Differencel betweenl typel 2l andl typel 3l hypersensitivity
Answer:
Typel 2l isl organl specific,l antibodyl bindsl tol thel antigenl onl thel celll surface
Typel 3l inl notl organl specific,l antibodyl bindsl tol solublel antigenl outsidel thel celll surfacel
thatl wasl releasedl intol thel bloodl orl bodyl fluidsl andl thenl depositedl inl thel tissues
QUESTION
Typel 3l hypersensitivityl Examples
Answer:
systemicl lupusl erythematosus,l rheumatoidl arthritis
QUESTION
Systemicl Lupusl Erythematosusl flare-upl triggers
Answer:
Stress,l infections,l sunlight,l hormonall changes,l orl certainl medications
QUESTION
