AOCNP (Advanced Oncology Certified Nurse
Practitioner) Test Questions And Correct Answers|
Latest Update
Treatments that place individuals at increased risk for infection
Chemotherapy treatments including high-dose cyclophosphamide, doxorubicin, docetaxel, or
alemtuzumab.
Colony stimulating factors (CSF)
**GM-CSF : growth factor for hematopoietic stem cells and granulocyte/monocytes
**M-CSF (macrophage): essential for macrophage production
**G-CSF (granulocyte) :essential for neutrophils
**Erythropoietin (EPO): growth factor for RBC
Filgrastim (Neupogen)
Pegfilgrastim (Neulasta)
Tbo-filgrastim (Granix)
Common side effects: mild to moderate bone pain
Used to patients at risk of experiencing treatment induced neutropenia
Major benefit: reducing the possibility of myelosuppression and permitting the continuation of
therapeutic chemotherapy doses
,Filgrastim (Neupogen)
Dose: 5 µg per kilogram per day. Begin 24 to 72 hours after completion of chemotherapy and
continue through the post nadir period.
Pegfilgrastim (Neulasta)
That was: 6 mg per cycle. Again 1 to 3 days post chemotherapy. Administer as a single 6 mg
injection once per cycle. Do not administer in the period beginning 14 days before until 24
hours after administration of chemotherapy.
Antimicrobial prophylaxis for infection
Low risk: no prophylaxis Recommended unless the patient has prior herpes simplex virus
episode.
Intermediate risk:
Bacterial: consider Fluoroquinolone
Fungal: consider fluconazole during neutropenia and if mucositis is anticipated
Viral: during neutropenia and at least 30 days after transplantation
High risk:
Bacterial: consider fluoroquinolone
Fungal: consider fluconazole or other anti-fungal agent
Viral: during neutropenia and at least 30 days after transplantation
Graft versus host disease: penicillin and trimethoprim/sulfamethoxazole (tmp/smx) Or
equivalent for allogeneic haematopoietic Stem cell transplant recipients
,Alemtuzumab: TMP/SMX
Complete diagnostic work up for neutropenic fever
Blood cultures: bacterial, viral, and fungal
BUN, electrolytes, and creatinine
Chest x-ray
CBC and differential
Liver function test
Pulse oximetry
Site-specific cytology and cultures
Urinalysis
ANC calculation
WBC x [(% segs + % bands)/100]
aplastic anemia
a normocytic-normochromic type of anemia characterized by the failure of bone marrow to
produce red blood cells
hemolytic anemia
characterized by an inadequate number of circulating red blood cells due to the premature
destruction of red blood cells by the spleen
, deficiency anemia
anemia caused by lack of necessary nutrients
B12, folate, and iron
Anemia # of RBC/ MCV
Microcytic. Normocytic. Macrocytic.
Microcytic anemia with ↓ serum iron, ↓ total iron-binding capacity (TIBC), and normal or ↑
ferritin.
cells smaller than normal
Iron deficiency
macrocytic anemia
due to folate or vitamin B12(cobalamin) deficiency (megaloblastic anemia), THF-M --> VitB12-M
--> Methionine, (transfer of methyl groups)
erythropoietin (EPO)
Stimulates development of RBC production
Triggered to release by reduced oxygen level of RBC mass trigger from the kidney
Labs to check in anemia
Practitioner) Test Questions And Correct Answers|
Latest Update
Treatments that place individuals at increased risk for infection
Chemotherapy treatments including high-dose cyclophosphamide, doxorubicin, docetaxel, or
alemtuzumab.
Colony stimulating factors (CSF)
**GM-CSF : growth factor for hematopoietic stem cells and granulocyte/monocytes
**M-CSF (macrophage): essential for macrophage production
**G-CSF (granulocyte) :essential for neutrophils
**Erythropoietin (EPO): growth factor for RBC
Filgrastim (Neupogen)
Pegfilgrastim (Neulasta)
Tbo-filgrastim (Granix)
Common side effects: mild to moderate bone pain
Used to patients at risk of experiencing treatment induced neutropenia
Major benefit: reducing the possibility of myelosuppression and permitting the continuation of
therapeutic chemotherapy doses
,Filgrastim (Neupogen)
Dose: 5 µg per kilogram per day. Begin 24 to 72 hours after completion of chemotherapy and
continue through the post nadir period.
Pegfilgrastim (Neulasta)
That was: 6 mg per cycle. Again 1 to 3 days post chemotherapy. Administer as a single 6 mg
injection once per cycle. Do not administer in the period beginning 14 days before until 24
hours after administration of chemotherapy.
Antimicrobial prophylaxis for infection
Low risk: no prophylaxis Recommended unless the patient has prior herpes simplex virus
episode.
Intermediate risk:
Bacterial: consider Fluoroquinolone
Fungal: consider fluconazole during neutropenia and if mucositis is anticipated
Viral: during neutropenia and at least 30 days after transplantation
High risk:
Bacterial: consider fluoroquinolone
Fungal: consider fluconazole or other anti-fungal agent
Viral: during neutropenia and at least 30 days after transplantation
Graft versus host disease: penicillin and trimethoprim/sulfamethoxazole (tmp/smx) Or
equivalent for allogeneic haematopoietic Stem cell transplant recipients
,Alemtuzumab: TMP/SMX
Complete diagnostic work up for neutropenic fever
Blood cultures: bacterial, viral, and fungal
BUN, electrolytes, and creatinine
Chest x-ray
CBC and differential
Liver function test
Pulse oximetry
Site-specific cytology and cultures
Urinalysis
ANC calculation
WBC x [(% segs + % bands)/100]
aplastic anemia
a normocytic-normochromic type of anemia characterized by the failure of bone marrow to
produce red blood cells
hemolytic anemia
characterized by an inadequate number of circulating red blood cells due to the premature
destruction of red blood cells by the spleen
, deficiency anemia
anemia caused by lack of necessary nutrients
B12, folate, and iron
Anemia # of RBC/ MCV
Microcytic. Normocytic. Macrocytic.
Microcytic anemia with ↓ serum iron, ↓ total iron-binding capacity (TIBC), and normal or ↑
ferritin.
cells smaller than normal
Iron deficiency
macrocytic anemia
due to folate or vitamin B12(cobalamin) deficiency (megaloblastic anemia), THF-M --> VitB12-M
--> Methionine, (transfer of methyl groups)
erythropoietin (EPO)
Stimulates development of RBC production
Triggered to release by reduced oxygen level of RBC mass trigger from the kidney
Labs to check in anemia
