Respiratory Pathophysiology
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1. External respira- •Mouth/nose/pharynx
tory system •Upper/lower airways
•Lungs
•Alveoli
ventilation
2. Internal respira- •Vasculature/capillaries
tory system •Red blood cells
•Tissue cells
diffusion
3. mucociliary blan- protects respiratory system by trapping dust, bacteria, and particles that enter the
ket airway
4. inspiration inhalation- chest cavity increases, negative pressure, air drawn into lungs, di-
aphragm contracts and moves down.
5. expiration exhalation- wall and lung structures recoil, chest cavity decreases and pressure
increases. diaphragm relaxes and moves up
6. Atmospheric the amount of force that is exerted by gases in the air surrounding any given
pressure surface, such as the body
7. Intrapulmonary Pressure inside lung decreases as lung volume increases during inspiration; pres-
pressure sure increases during expiration.
8. Intrapleural pres- Pleural cavity pressure becomes more negative as chest wall expands during
sure inspiration. Returns to initial value as chest wall recoils.
9. Volume of breath During each breath, the pressure gradients move 0.5 liter of air into and out of the
lungs.
10. Diffusion transfer of gases between alveoli and pulmonary cavities
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