Pathophysiology - Anemia
Pathophysiology - Anemia.pdf
Study online at https://quizlet.com/_hyg7e
1. Anemia comes from the Greek word "without blood". Its a decrease of RBC causing
weakness and fatigue.
2. Hemolytic Ane- removes RBC's before their allotted time of 120 day life cycle.
mia
3. Lysis to break up
4. Heme Means blood. It contains porphyrin and iron (metals). Four hemes combine with
one globin
5. Spleen removes RBC's from circulation. When the spleen destroys the RBC, the hemoglo-
bin is taken out and converted into bilirubin (colors urine and stool) which is how
it is excreted from the body
6. Reticuloendothe- traps red blood cells after they age and destroys them. They take them out of
lial tissue circulation.
7. bone marrow thick viscous type of fluid, tissue, fills up hollow space in diaphysis and in spongy
bone. This is where RBCs, WBCs and platelets (thrombocytes) are made
8. Pluropotential gives rise to all three of these cells (RBC, WBC, and platelets). When erythropoietin
stem cell binds to this, it gives a signal to the stem cell to create more RBCs
9. Kidney releases the hormone erythropoietin which stimulates erythropoiesis.
10. Recombinant take the DNA (gene) from own cell, get a virus to take it up, have the virus deliver
DNA technology it to yeast, then gene transplant will occur. This process isolates the DNA that
makes erythropoietin, virus delivers it in yeast (that has human DNA to make
erythropoietin). This allows you to get an injection of erythropoietin.
11. Chemotherapy -Kills actively dividing cells. So many immature RBCs are killed leading to anemia.
Side effects are nausea, vomiting, weakness, fatigue, hair loss and anemia. An
injection of erythropoietin (Procrit, Epogen, and Epovere) is given to help with side
, Pathophysiology - Anemia
Pathophysiology - Anemia.pdf
Study online at https://quizlet.com/_hyg7e
effects and regain RBC's . Too many RBC's may create blood clots and may lead to
heart attacks.
12. Methemoglobin at the end of the 120 day life cycle, this is recognized in the RBC. It is destroyed
in the spleen when the spleen recognizes that there is a sufficient amount of
methemoglobin in the RBC.
13. Globin is made up of 4 large polypeptide chains: 2 alpha chains and 2 beta chains.
14. Iron must be consumed through food. It cannot be created by the body. It can only be
stored and recycled after being consumed. It attaches to oxygen in the blood. you
cannot recycle this if you lose blood.
15. Coenzymes -required for hemoglobin to be made properly.
-vitamin B12 (only comes from animal sources)
16. Vitamin B12 - comes only from animal sources
- If this passes the stomach and moves into the intestines, its gone. The hydrochlo-
ric acid will destroy it.
- this vitamin must be absorbed into the bloodstream immediately by crossing the
wall of the stomach and wall of capillary.
-intrinsic factor binds to this vitamin and pulls it across the stomach wall and
capillary wall into the bloodstream.
17. Intrinsic factor - binds to vitamin b12 and pulls it across the stomach wall and capillary wall into
the bloodstream.
- parietal cells line the inside of the stomach and make this.
- if there is a problem creating this, an injection of Vitamin B12 will be given directly
into the bloodstream.
18. Pernicious ane- Lack of intrinsic factor in the body. Person would need to get injections of Vitamin
mia B12 directly into the bloodstream. Can be a side effect of bariatric surgery because
Pathophysiology - Anemia.pdf
Study online at https://quizlet.com/_hyg7e
1. Anemia comes from the Greek word "without blood". Its a decrease of RBC causing
weakness and fatigue.
2. Hemolytic Ane- removes RBC's before their allotted time of 120 day life cycle.
mia
3. Lysis to break up
4. Heme Means blood. It contains porphyrin and iron (metals). Four hemes combine with
one globin
5. Spleen removes RBC's from circulation. When the spleen destroys the RBC, the hemoglo-
bin is taken out and converted into bilirubin (colors urine and stool) which is how
it is excreted from the body
6. Reticuloendothe- traps red blood cells after they age and destroys them. They take them out of
lial tissue circulation.
7. bone marrow thick viscous type of fluid, tissue, fills up hollow space in diaphysis and in spongy
bone. This is where RBCs, WBCs and platelets (thrombocytes) are made
8. Pluropotential gives rise to all three of these cells (RBC, WBC, and platelets). When erythropoietin
stem cell binds to this, it gives a signal to the stem cell to create more RBCs
9. Kidney releases the hormone erythropoietin which stimulates erythropoiesis.
10. Recombinant take the DNA (gene) from own cell, get a virus to take it up, have the virus deliver
DNA technology it to yeast, then gene transplant will occur. This process isolates the DNA that
makes erythropoietin, virus delivers it in yeast (that has human DNA to make
erythropoietin). This allows you to get an injection of erythropoietin.
11. Chemotherapy -Kills actively dividing cells. So many immature RBCs are killed leading to anemia.
Side effects are nausea, vomiting, weakness, fatigue, hair loss and anemia. An
injection of erythropoietin (Procrit, Epogen, and Epovere) is given to help with side
, Pathophysiology - Anemia
Pathophysiology - Anemia.pdf
Study online at https://quizlet.com/_hyg7e
effects and regain RBC's . Too many RBC's may create blood clots and may lead to
heart attacks.
12. Methemoglobin at the end of the 120 day life cycle, this is recognized in the RBC. It is destroyed
in the spleen when the spleen recognizes that there is a sufficient amount of
methemoglobin in the RBC.
13. Globin is made up of 4 large polypeptide chains: 2 alpha chains and 2 beta chains.
14. Iron must be consumed through food. It cannot be created by the body. It can only be
stored and recycled after being consumed. It attaches to oxygen in the blood. you
cannot recycle this if you lose blood.
15. Coenzymes -required for hemoglobin to be made properly.
-vitamin B12 (only comes from animal sources)
16. Vitamin B12 - comes only from animal sources
- If this passes the stomach and moves into the intestines, its gone. The hydrochlo-
ric acid will destroy it.
- this vitamin must be absorbed into the bloodstream immediately by crossing the
wall of the stomach and wall of capillary.
-intrinsic factor binds to this vitamin and pulls it across the stomach wall and
capillary wall into the bloodstream.
17. Intrinsic factor - binds to vitamin b12 and pulls it across the stomach wall and capillary wall into
the bloodstream.
- parietal cells line the inside of the stomach and make this.
- if there is a problem creating this, an injection of Vitamin B12 will be given directly
into the bloodstream.
18. Pernicious ane- Lack of intrinsic factor in the body. Person would need to get injections of Vitamin
mia B12 directly into the bloodstream. Can be a side effect of bariatric surgery because
