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, Pathophysiology - Renal
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1. The severity of an ob- 1) location
structive uropathy is de- 2) involvement of one or both upper urinary tracts
termined by what 5 fac- 3) completeness of obstruction
tors? 4) duration of obstruction
5) nature of obstructive lesion
2. What are the different - anatomical
types of urinary tract - functional
obstruction? - instrinsic
- extrinsic
3. What are examples of - ureteral stone
anatomical urinary tract - tumor
obstruction?
4. What are examples of - impaired peristalsis
functional urinary tract - neurogenic bladder
obstruction?
5. What are examples of - calculus
instrinsic urinary tract - blood clot
obstruction? - tumor
6. What are examples of - pregnancy
extrinsic urinary tract - aberrant vessel
obstruction? - prostatic hypertrophy
7. How do kidneys com- contralateral kidney increases size of individual glomeruli and tubules
pensate for urinary
tract obstruction?
8. What is the most com- congenital anomalies
mon cause of urinary
, Pathophysiology - Renal
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tract obstruction in chil-
dren?
9. What is the most com- calculi
mon cause of uri-
nary tract obstruction in
adults?
10. What is the most com- prostatic hypertrophy
mon cause of urinary
tract obstruction in old-
er men?
11. What are the complica- - increased pressure (hydroureter + hydronephrosis)
tions of urinary tract ob- - decreased glomerular blood flow and GFR
struction? - tubulointerstitial fibrosis
12. What is tubulointersti- progressive, non-reversible deposition of connective tissue in renal
tial fibrosis? parenchyma resulting in chronic renal disease
13. After how many days 7 days
does tubulointerstitial
fibrosis result in de-
tectable damage to the
distal renal tubules?
14. Distal tubular dam- distal tubular damage decreases the kidney's ability to concentrate
age occurs initially in urine, causing increase in urine volume despite a decrease in GFR
tubulointerstitial fibro-
sis. How does this affect
urinary output?
15.