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, Pathophysiology ch11
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1. List the three Pluripotent stem cells
types of cells of Multipotent stem cells
the hematopoietic Committed progenitor cells
system.
2. Trace the develop- The Pluripotent stem cell gives rise to the lymphoid stem cell and the myeloid
ment of the dif- stem cell. These both differentiate into different cells. The Lymphoid stem cell
ferent blood cells differentiates into T cells, B cells, and natural killer (NK) cells. B cells turn into
from their origin plasma cells.
in the pluripo-
tent bone marrow Meanwhile, myeloid stem cells differentiate into monocytes, granulocytes,
stem cell to their megakaryocytes, and erythrocytes. Monocytes turn into monoblasts.
circulation in the
Granulocytes turn into eosinophils, neutrophils, and basophils.
bloodstream.
Megakaryocytes turn into platelets. Erythrocytes turn into reticulocytes. This is
what circulates in the blood stream.
3. List the three Agranulocytes are divided into 2 different parts: lymphocytes and mono-
types of white cytes/macrophages.
blood cells and
briefly describe Lymphocytes: make up 30% of leukocytes. They originate in bone marrow and
their function. migrate through peripheral lymphoid organs where they recognize antigens and
participate in immune responses.
Monocytes/macrophages: make up 3-8% of leukocytes. They travel from bone
marrow to body tissue where they differentiate into various phagocytes.
4. List the three sub- Neutrophils: make up 60-65% of leukocytes. They maintain normal host defenses
types of granulo- against invading bacteria nad fungi cell debris, and a variety of foreign sub-
cytes and briefly stances.
describe their
role. Eosinophils: make up 1-3% of leukocytes. They are a part of 2 reactions. Allergic