Cardiac Pathophysiology
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1. non modifiable risk factors for atherosclerosis • Male sex
• Family history
• Advancing age •
Esp. post-menopause for
women
• Genetics
• Familial hypercholes-
terolemia
2. modifiable risk factors for atherosclerosis • Smoking
• Diet
• Physical inactivity
• Obesity
3. in between atherosclerosis risk factors • Dyslipidemia
• Hypertension
4. What does arterial/arteriolar endothelium produce nitric oxide
5. what is the role of Nitric oxide on the arterial/arteriolar • Nitric oxide vasodila-
endothelium tor the artery and has
anti-platelet and anti-in-
flammatory effects
6. when does the arterial/arteriolar endothelium release in response to:
NO • Shear stress on vessel
wall (increased BP or HR)
• Chemical signals (acetyl-
choline/ parasympathetic
stimulation)
7. what is smokings effect on NO production in the arte- inhibits the production of
rial/arteriolar endothelium NO