Hypersensitivity
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, Pathophysiology: Hypersensitivity
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1. What are hyper- Immune responses that cause tissue injury and disease
sensitivity reac-
tions?
2. What happens -B cells and T cells attack their own cells because they lose the ability to recognize
when you have self from non-self
an autoimmune -B cells produce antibodies against an altered "self", called autoantibodies
disease?
3. What is immun- An inadequate immune response
odeficiency?
4. What happens to There is a decline in responsiveness due to the breakdown of normal components
our immune sys- in our immune system
tem as we age?
5. What antibody or IgE antibodies
cell is involved
in hypersensitivi-
ty reaction I?
6. What occurs dur- IgE antibodies attach to Mast cells (and specific antigen) which causes the mast
ing a hypersensi- cells to degranulate and release inflammatory mediators (histamine)
tivity reaction I?
7. What are exam- Anaphylaxis and atopic
ples of hypersen-
sitivity reaction I?
8. What are atopic Local immune reactions that are confined to the site of exposure to an antigen,
reactions? such as in the case of a food allergy or allergic rhinitis (seasonal allergies)
9. Acetylecholine initiates bronchospasm causing airways to get tight and hives
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