Pathophysiology: Cellular
Adaptation
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1. Define adapta- Cells adapt to their enviornment to escape and protect themselves from injury. An
tion adapted cell is neither normal or injured. Unable to maintain homeostasis
2. Describe atrophy, atrophy: decrease in cell size
hypertrophy, hy- -physiological atrophy: occurs in early development, thymus undergoes physiolog-
perplasia, dyspla- ical atrophy during childhood.
sia, and metapla- -pathologic atrophy: Decrease in workload such as blood supply, nutrition, hor-
sia monal stimulation, and nervous system stimulation
-Disuse atrophy: Individuals who are immobilized in bed for a prolonged time can
develop disuse atrophy also aging which includes increased catabolism, chronic
malnutrition and lipofuscin.
hypertrophy: due to an increase in organ size
-hormonal stimulation or increased functional demand
-mechanical signals: stretching
physiological: skeletal muscle, kidneys, pregnancy
-pathologic: heart atrophy
hyperplasia: increase number of cells
dysplasia: abnormal size, shape, and organization of mature cells
metaplasia: reversible replacement of one type of cell by another.
3. The three ba- Hypoxia: lack of sufficient oxygen within cells, is the most common cause of cellular
sic mechanisms injury. A reduced amount of O2 in the air , loss of hemoglobin or decreased
of cell injury efficiency of hemoglobin and decreased production of red blood cells. Hypoxia
plays an important role in physiologic process including cell differinciation, ery-
thropoesis, proliferation. it is associated with inflammation, ischemia, and cancer.
Induce inflammation and inflamed lesions can become hypoxic
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